Fluorine in PDB 8fho: Cryo-Em Structure of Human Ncc (Class 1)

The structure of Cryo-Em Structure of Human Ncc (Class 1) also contains other interesting chemical elements:

Chlorine	(Cl)	2 atoms
Sodium	(Na)	2 atoms

The binding sites of Fluorine atom in the Cryo-Em Structure of Human Ncc (Class 1) (pdb code 8fho). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Cryo-Em Structure of Human Ncc (Class 1), PDB code: 8fho:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;

Fluorine binding site 1 out of 6 in the Cryo-Em Structure of Human Ncc (Class 1)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of Human Ncc (Class 1) within 5.0Å range: probe atom residue distance (Å) B Occ A:F1102 b:31.4 occ:1.00 F05 A:XZF1102 0.0 31.4 1.0 C25 A:XZF1102 1.4 31.4 1.0 F07 A:XZF1102 2.2 31.4 1.0 F06 A:XZF1102 2.2 31.4 1.0 C24 A:XZF1102 2.4 31.4 1.0 CE A:MET233 2.9 30.8 1.0 CG2 A:ILE532 3.3 29.7 1.0 CB A:ILE532 3.5 29.7 1.0 N A:SER533 3.9 28.4 1.0 S03 A:XZF1102 3.9 31.4 1.0 O A:ALA529 3.9 33.4 1.0 C A:ILE532 4.1 29.7 1.0 C18 A:XZF1102 4.3 31.4 1.0 CA A:SER533 4.3 28.4 1.0 CA A:ILE532 4.4 29.7 1.0 CB A:SER533 4.5 28.4 1.0 CA A:ALA529 4.5 33.4 1.0 O09 A:XZF1102 4.5 31.4 1.0 CG1 A:ILE532 4.6 29.7 1.0 O A:ILE532 4.7 29.7 1.0 SD A:MET233 4.7 30.8 1.0 C A:ALA529 4.7 33.4 1.0 CB A:ALA529 4.8 33.4 1.0 CE2 A:PHE536 5.0 27.6 1.0

Fluorine binding site 2 out of 6 in the Cryo-Em Structure of Human Ncc (Class 1)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Cryo-Em Structure of Human Ncc (Class 1) within 5.0Å range: probe atom residue distance (Å) B Occ A:F1102 b:31.4 occ:1.00 F06 A:XZF1102 0.0 31.4 1.0 C25 A:XZF1102 1.4 31.4 1.0 F07 A:XZF1102 2.2 31.4 1.0 F05 A:XZF1102 2.2 31.4 1.0 C24 A:XZF1102 2.4 31.4 1.0 CE A:MET233 3.1 30.8 1.0 S03 A:XZF1102 3.3 31.4 1.0 CB A:MET233 4.0 30.8 1.0 O09 A:XZF1102 4.5 31.4 1.0 C18 A:XZF1102 4.5 31.4 1.0 SD A:MET233 4.5 30.8 1.0 CG A:MET233 4.6 30.8 1.0 CE1 A:HIS234 4.6 29.8 1.0 NE2 A:HIS234 4.6 29.8 1.0

Fluorine binding site 3 out of 6 in the Cryo-Em Structure of Human Ncc (Class 1)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Cryo-Em Structure of Human Ncc (Class 1) within 5.0Å range: probe atom residue distance (Å) B Occ A:F1102 b:31.4 occ:1.00 F07 A:XZF1102 0.0 31.4 1.0 C25 A:XZF1102 1.4 31.4 1.0 F06 A:XZF1102 2.2 31.4 1.0 F05 A:XZF1102 2.2 31.4 1.0 C24 A:XZF1102 2.4 31.4 1.0 O09 A:XZF1102 2.5 31.4 1.0 S03 A:XZF1102 2.7 31.4 1.0 C18 A:XZF1102 3.0 31.4 1.0 S02 A:XZF1102 3.6 31.4 1.0 N12 A:XZF1102 3.6 31.4 1.0 C15 A:XZF1102 3.8 31.4 1.0 CE2 A:PHE536 4.1 27.6 1.0 NE2 A:HIS234 4.4 29.8 1.0 CG2 A:ILE532 4.4 29.7 1.0 C19 A:XZF1102 4.4 31.4 1.0 CD2 A:PHE536 4.4 27.6 1.0 O08 A:XZF1102 4.5 31.4 1.0 CE A:MET233 4.5 30.8 1.0 N13 A:XZF1102 4.5 31.4 1.0 CE1 A:HIS234 4.7 29.8 1.0 CA A:GLY230 4.8 27.3 1.0 C16 A:XZF1102 4.8 31.4 1.0

Fluorine binding site 4 out of 6 in the Cryo-Em Structure of Human Ncc (Class 1)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Cryo-Em Structure of Human Ncc (Class 1) within 5.0Å range: probe atom residue distance (Å) B Occ B:F1102 b:46.8 occ:1.00 F05 B:XZF1102 0.0 46.8 1.0 C25 B:XZF1102 1.4 46.8 1.0 F06 B:XZF1102 2.2 46.8 1.0 F07 B:XZF1102 2.2 46.8 1.0 C24 B:XZF1102 2.3 46.8 1.0 S03 B:XZF1102 2.8 46.8 1.0 C18 B:XZF1102 3.4 46.8 1.0 CB B:SER533 3.4 39.3 1.0 O B:ALA529 3.4 47.3 1.0 CA B:SER533 3.6 39.3 1.0 N B:SER533 3.6 39.3 1.0 C B:ILE532 4.3 41.4 1.0 OG B:SER533 4.3 39.3 1.0 C B:ALA529 4.4 47.3 1.0 CA B:ALA529 4.6 47.3 1.0 O B:ILE532 4.6 41.4 1.0 CG2 B:ILE532 4.7 41.4 1.0 SD B:MET233 4.7 48.8 1.0 CB B:ALA529 4.8 47.3 1.0 C15 B:XZF1102 4.8 46.8 1.0 CB B:ILE532 4.9 41.4 1.0

Fluorine binding site 5 out of 6 in the Cryo-Em Structure of Human Ncc (Class 1)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Cryo-Em Structure of Human Ncc (Class 1) within 5.0Å range: probe atom residue distance (Å) B Occ B:F1102 b:46.8 occ:1.00 F06 B:XZF1102 0.0 46.8 1.0 C25 B:XZF1102 1.4 46.8 1.0 F07 B:XZF1102 2.2 46.8 1.0 F05 B:XZF1102 2.2 46.8 1.0 C24 B:XZF1102 2.4 46.8 1.0 SD B:MET233 2.5 48.8 1.0 CE B:MET233 3.2 48.8 1.0 S03 B:XZF1102 3.9 46.8 1.0 CG B:MET233 4.1 48.8 1.0 O B:ALA529 4.2 47.3 1.0 CA B:ALA529 4.2 47.3 1.0 CB B:ALA529 4.3 47.3 1.0 CB B:MET233 4.5 48.8 1.0 CG2 B:ILE532 4.6 41.4 1.0 C18 B:XZF1102 4.6 46.8 1.0 C B:ALA529 4.7 47.3 1.0 CB B:ILE532 4.9 41.4 1.0

Fluorine binding site 6 out of 6 in the Cryo-Em Structure of Human Ncc (Class 1)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Cryo-Em Structure of Human Ncc (Class 1) within 5.0Å range: probe atom residue distance (Å) B Occ B:F1102 b:46.8 occ:1.00 F07 B:XZF1102 0.0 46.8 1.0 C25 B:XZF1102 1.4 46.8 1.0 F06 B:XZF1102 2.2 46.8 1.0 F05 B:XZF1102 2.2 46.8 1.0 C24 B:XZF1102 2.4 46.8 1.0 C18 B:XZF1102 3.0 46.8 1.0 S03 B:XZF1102 3.2 46.8 1.0 O09 B:XZF1102 3.6 46.8 1.0 CG2 B:ILE532 3.7 41.4 1.0 CE2 B:PHE536 3.8 39.5 1.0 SD B:MET233 4.0 48.8 1.0 C15 B:XZF1102 4.3 46.8 1.0 CD2 B:PHE536 4.4 39.5 1.0 O B:ILE532 4.5 41.4 1.0 C B:ILE532 4.6 41.4 1.0 N B:SER533 4.6 39.3 1.0 CB B:ILE532 4.6 41.4 1.0 N12 B:XZF1102 4.6 46.8 1.0 S02 B:XZF1102 4.7 46.8 1.0 CA B:SER533 4.8 39.3 1.0 CA B:GLY230 4.8 43.6 1.0 CZ B:PHE536 4.9 39.5 1.0 N13 B:XZF1102 5.0 46.8 1.0 O B:ALA529 5.0 47.3 1.0

M.Fan, J.Zhang, C.Lee, J.Zhang, L.Feng. Structure and Thiazide Inhibition Mechanism of the Human Na-Cl Cotransporter Nature 2023.
ISSN: ESSN 1476-4687
DOI: 10.1038/S41586-023-05718-0