Fluorine in PDB 8fhp: Cryo-Em Structure of Human Ncc (Class 3-1)

The structure of Cryo-Em Structure of Human Ncc (Class 3-1) also contains other interesting chemical elements:

Sodium	(Na)	2 atoms
Chlorine	(Cl)	2 atoms

The binding sites of Fluorine atom in the Cryo-Em Structure of Human Ncc (Class 3-1) (pdb code 8fhp). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Cryo-Em Structure of Human Ncc (Class 3-1), PDB code: 8fhp:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;

Fluorine binding site 1 out of 6 in the Cryo-Em Structure of Human Ncc (Class 3-1)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of Human Ncc (Class 3-1) within 5.0Å range: probe atom residue distance (Å) B Occ A:F1101 b:53.8 occ:1.00 F05 A:XZF1101 0.0 53.8 1.0 C25 A:XZF1101 1.4 53.8 1.0 F06 A:XZF1101 2.2 53.8 1.0 F07 A:XZF1101 2.2 53.8 1.0 C24 A:XZF1101 2.3 53.8 1.0 S03 A:XZF1101 2.6 53.8 1.0 C18 A:XZF1101 3.1 53.8 1.0 CB A:SER533 3.1 49.7 1.0 CA A:SER533 3.4 49.7 1.0 N A:SER533 3.6 49.7 1.0 O A:ALA529 3.8 57.9 1.0 OG A:SER533 3.9 49.7 1.0 C A:ILE532 4.4 49.1 1.0 CE A:MET233 4.5 50.3 1.0 C15 A:XZF1101 4.5 53.8 1.0 CG2 A:ILE532 4.6 49.1 1.0 CB A:ILE532 4.8 49.1 1.0 CB A:PRO349 4.8 51.9 1.0 CD2 A:PHE536 4.8 47.7 1.0 C A:ALA529 4.8 57.9 1.0 O A:ILE532 4.9 49.1 1.0 C A:SER533 4.9 49.7 1.0

Fluorine binding site 2 out of 6 in the Cryo-Em Structure of Human Ncc (Class 3-1)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Cryo-Em Structure of Human Ncc (Class 3-1) within 5.0Å range: probe atom residue distance (Å) B Occ A:F1101 b:53.8 occ:1.00 F06 A:XZF1101 0.0 53.8 1.0 C25 A:XZF1101 1.4 53.8 1.0 F05 A:XZF1101 2.2 53.8 1.0 F07 A:XZF1101 2.2 53.8 1.0 C24 A:XZF1101 2.3 53.8 1.0 CE A:MET233 3.1 50.3 1.0 SD A:MET233 3.6 50.3 1.0 S03 A:XZF1101 3.8 53.8 1.0 CB A:ALA529 3.9 57.9 1.0 O A:ALA529 4.0 57.9 1.0 CA A:ALA529 4.1 57.9 1.0 C A:ALA529 4.5 57.9 1.0 C18 A:XZF1101 4.6 53.8 1.0 CB A:SER533 4.9 49.7 1.0 N A:SER533 5.0 49.7 1.0 CB A:ILE532 5.0 49.1 1.0

Fluorine binding site 3 out of 6 in the Cryo-Em Structure of Human Ncc (Class 3-1)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Cryo-Em Structure of Human Ncc (Class 3-1) within 5.0Å range: probe atom residue distance (Å) B Occ A:F1101 b:53.8 occ:1.00 F07 A:XZF1101 0.0 53.8 1.0 C25 A:XZF1101 1.4 53.8 1.0 F05 A:XZF1101 2.2 53.8 1.0 F06 A:XZF1101 2.2 53.8 1.0 C24 A:XZF1101 2.4 53.8 1.0 CE A:MET233 3.0 50.3 1.0 C18 A:XZF1101 3.1 53.8 1.0 S03 A:XZF1101 3.3 53.8 1.0 O09 A:XZF1101 3.6 53.8 1.0 CG2 A:ILE532 4.0 49.1 1.0 C15 A:XZF1101 4.3 53.8 1.0 CE2 A:PHE536 4.3 47.7 1.0 N12 A:XZF1101 4.4 53.8 1.0 SD A:MET233 4.5 50.3 1.0 CD2 A:PHE536 4.6 47.7 1.0 CB A:ILE532 4.6 49.1 1.0 S02 A:XZF1101 4.6 53.8 1.0 N A:SER533 4.9 49.7 1.0 CA A:GLY230 4.9 45.0 1.0 C19 A:XZF1101 4.9 53.8 1.0

Fluorine binding site 4 out of 6 in the Cryo-Em Structure of Human Ncc (Class 3-1)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Cryo-Em Structure of Human Ncc (Class 3-1) within 5.0Å range: probe atom residue distance (Å) B Occ B:F1101 b:53.7 occ:1.00 F05 B:XZF1101 0.0 53.7 1.0 C25 B:XZF1101 1.4 53.7 1.0 F06 B:XZF1101 2.2 53.7 1.0 F07 B:XZF1101 2.2 53.7 1.0 C24 B:XZF1101 2.3 53.7 1.0 S03 B:XZF1101 2.6 53.7 1.0 C18 B:XZF1101 3.1 53.7 1.0 CB B:SER533 3.1 50.0 1.0 CA B:SER533 3.4 50.0 1.0 N B:SER533 3.6 50.0 1.0 O B:ALA529 3.8 58.1 1.0 OG B:SER533 3.9 50.0 1.0 C B:ILE532 4.4 49.1 1.0 CE B:MET233 4.5 50.1 1.0 C15 B:XZF1101 4.5 53.7 1.0 CG2 B:ILE532 4.6 49.1 1.0 CB B:ILE532 4.8 49.1 1.0 CB B:PRO349 4.8 51.5 1.0 CD2 B:PHE536 4.8 47.4 1.0 C B:ALA529 4.8 58.1 1.0 O B:ILE532 4.9 49.1 1.0 C B:SER533 4.9 50.0 1.0

Fluorine binding site 5 out of 6 in the Cryo-Em Structure of Human Ncc (Class 3-1)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Cryo-Em Structure of Human Ncc (Class 3-1) within 5.0Å range: probe atom residue distance (Å) B Occ B:F1101 b:53.7 occ:1.00 F06 B:XZF1101 0.0 53.7 1.0 C25 B:XZF1101 1.4 53.7 1.0 F05 B:XZF1101 2.2 53.7 1.0 F07 B:XZF1101 2.2 53.7 1.0 C24 B:XZF1101 2.3 53.7 1.0 CE B:MET233 3.1 50.1 1.0 SD B:MET233 3.6 50.1 1.0 S03 B:XZF1101 3.8 53.7 1.0 CB B:ALA529 3.9 58.1 1.0 O B:ALA529 4.0 58.1 1.0 CA B:ALA529 4.1 58.1 1.0 C B:ALA529 4.5 58.1 1.0 C18 B:XZF1101 4.6 53.7 1.0 CB B:SER533 4.9 50.0 1.0 N B:SER533 5.0 50.0 1.0 CB B:ILE532 5.0 49.1 1.0

Fluorine binding site 6 out of 6 in the Cryo-Em Structure of Human Ncc (Class 3-1)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Cryo-Em Structure of Human Ncc (Class 3-1) within 5.0Å range: probe atom residue distance (Å) B Occ B:F1101 b:53.7 occ:1.00 F07 B:XZF1101 0.0 53.7 1.0 C25 B:XZF1101 1.4 53.7 1.0 F05 B:XZF1101 2.2 53.7 1.0 F06 B:XZF1101 2.2 53.7 1.0 C24 B:XZF1101 2.4 53.7 1.0 CE B:MET233 3.0 50.1 1.0 C18 B:XZF1101 3.1 53.7 1.0 S03 B:XZF1101 3.3 53.7 1.0 O09 B:XZF1101 3.6 53.7 1.0 CG2 B:ILE532 4.0 49.1 1.0 C15 B:XZF1101 4.3 53.7 1.0 CE2 B:PHE536 4.3 47.4 1.0 N12 B:XZF1101 4.4 53.7 1.0 SD B:MET233 4.5 50.1 1.0 CD2 B:PHE536 4.6 47.4 1.0 CB B:ILE532 4.6 49.1 1.0 S02 B:XZF1101 4.6 53.7 1.0 N B:SER533 4.9 50.0 1.0 CA B:GLY230 4.9 45.0 1.0 C19 B:XZF1101 4.9 53.7 1.0

M.Fan, J.Zhang, C.Lee, J.Zhang, L.Feng. Structure and Thiazide Inhibition Mechanism of the Human Na-Cl Cotransporter Nature 2023.
ISSN: ESSN 1476-4687
DOI: 10.1038/S41586-023-05718-0