Fluorine in PDB 8fhq: Cryo-Em Structure of Human Ncc (Class 3-2)

Other elements in 8fhq:

The structure of Cryo-Em Structure of Human Ncc (Class 3-2) also contains other interesting chemical elements:

Sodium (Na) 2 atoms
Chlorine (Cl) 2 atoms

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Cryo-Em Structure of Human Ncc (Class 3-2) (pdb code 8fhq). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Cryo-Em Structure of Human Ncc (Class 3-2), PDB code: 8fhq:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;

Fluorine binding site 1 out of 6 in 8fhq

Go back to Fluorine Binding Sites List in 8fhq
Fluorine binding site 1 out of 6 in the Cryo-Em Structure of Human Ncc (Class 3-2)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of Human Ncc (Class 3-2) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F1101

b:42.1
occ:1.00
F05 A:XZF1101 0.0 42.1 1.0
C25 A:XZF1101 1.4 42.1 1.0
F06 A:XZF1101 2.2 42.1 1.0
F07 A:XZF1101 2.2 42.1 1.0
C24 A:XZF1101 2.3 42.1 1.0
S03 A:XZF1101 2.7 42.1 1.0
C18 A:XZF1101 3.1 42.1 1.0
CB A:SER533 3.3 37.1 1.0
CA A:SER533 3.6 37.1 1.0
O A:ALA529 3.7 45.1 1.0
N A:SER533 3.7 37.1 1.0
OG A:SER533 4.1 37.1 1.0
C A:ILE532 4.4 38.7 1.0
C15 A:XZF1101 4.5 42.1 1.0
CG2 A:ILE532 4.6 38.7 1.0
C A:ALA529 4.6 45.1 1.0
CB A:ILE532 4.7 38.7 1.0
CB A:ALA529 4.8 45.1 1.0
O A:ILE532 4.8 38.7 1.0
CA A:ALA529 4.8 45.1 1.0
SD A:MET233 4.8 40.6 1.0

Fluorine binding site 2 out of 6 in 8fhq

Go back to Fluorine Binding Sites List in 8fhq
Fluorine binding site 2 out of 6 in the Cryo-Em Structure of Human Ncc (Class 3-2)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Cryo-Em Structure of Human Ncc (Class 3-2) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F1101

b:42.1
occ:1.00
F06 A:XZF1101 0.0 42.1 1.0
C25 A:XZF1101 1.4 42.1 1.0
F07 A:XZF1101 2.2 42.1 1.0
F05 A:XZF1101 2.2 42.1 1.0
C24 A:XZF1101 2.3 42.1 1.0
SD A:MET233 2.7 40.6 1.0
CB A:ALA529 3.8 45.1 1.0
S03 A:XZF1101 3.9 42.1 1.0
CA A:ALA529 3.9 45.1 1.0
CE A:MET233 3.9 40.6 1.0
O A:ALA529 4.0 45.1 1.0
CG A:MET233 4.1 40.6 1.0
CG2 A:ILE532 4.4 38.7 1.0
CB A:ILE532 4.4 38.7 1.0
C A:ALA529 4.5 45.1 1.0
CB A:MET233 4.5 40.6 1.0
C18 A:XZF1101 4.6 42.1 1.0
N A:SER533 4.9 37.1 1.0

Fluorine binding site 3 out of 6 in 8fhq

Go back to Fluorine Binding Sites List in 8fhq
Fluorine binding site 3 out of 6 in the Cryo-Em Structure of Human Ncc (Class 3-2)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Cryo-Em Structure of Human Ncc (Class 3-2) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F1101

b:42.1
occ:1.00
F07 A:XZF1101 0.0 42.1 1.0
C25 A:XZF1101 1.4 42.1 1.0
F06 A:XZF1101 2.2 42.1 1.0
F05 A:XZF1101 2.2 42.1 1.0
C24 A:XZF1101 2.4 42.1 1.0
C18 A:XZF1101 3.1 42.1 1.0
S03 A:XZF1101 3.3 42.1 1.0
CG2 A:ILE532 3.5 38.7 1.0
O09 A:XZF1101 3.7 42.1 1.0
SD A:MET233 3.8 40.6 1.0
CE2 A:PHE536 4.1 36.7 1.0
CB A:ILE532 4.2 38.7 1.0
C15 A:XZF1101 4.4 42.1 1.0
CD2 A:PHE536 4.5 36.7 1.0
CA A:GLY230 4.6 35.4 1.0
C A:ILE532 4.6 38.7 1.0
N A:SER533 4.6 37.1 1.0
O A:ILE532 4.8 38.7 1.0
N12 A:XZF1101 4.8 42.1 1.0
S02 A:XZF1101 4.8 42.1 1.0
CA A:SER533 4.9 37.1 1.0

Fluorine binding site 4 out of 6 in 8fhq

Go back to Fluorine Binding Sites List in 8fhq
Fluorine binding site 4 out of 6 in the Cryo-Em Structure of Human Ncc (Class 3-2)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Cryo-Em Structure of Human Ncc (Class 3-2) within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F1101

b:42.2
occ:1.00
F05 B:XZF1101 0.0 42.2 1.0
C25 B:XZF1101 1.4 42.2 1.0
F06 B:XZF1101 2.2 42.2 1.0
F07 B:XZF1101 2.2 42.2 1.0
C24 B:XZF1101 2.3 42.2 1.0
S03 B:XZF1101 2.7 42.2 1.0
C18 B:XZF1101 3.1 42.2 1.0
CB B:SER533 3.3 37.7 1.0
CA B:SER533 3.6 37.7 1.0
O B:ALA529 3.7 46.1 1.0
N B:SER533 3.7 37.7 1.0
OG B:SER533 4.1 37.7 1.0
C B:ILE532 4.4 39.3 1.0
C15 B:XZF1101 4.5 42.2 1.0
CG2 B:ILE532 4.6 39.3 1.0
C B:ALA529 4.6 46.1 1.0
CB B:ILE532 4.7 39.3 1.0
CB B:ALA529 4.8 46.1 1.0
O B:ILE532 4.8 39.3 1.0
CA B:ALA529 4.8 46.1 1.0
SD B:MET233 4.8 41.0 1.0

Fluorine binding site 5 out of 6 in 8fhq

Go back to Fluorine Binding Sites List in 8fhq
Fluorine binding site 5 out of 6 in the Cryo-Em Structure of Human Ncc (Class 3-2)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Cryo-Em Structure of Human Ncc (Class 3-2) within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F1101

b:42.2
occ:1.00
F06 B:XZF1101 0.0 42.2 1.0
C25 B:XZF1101 1.4 42.2 1.0
F07 B:XZF1101 2.2 42.2 1.0
F05 B:XZF1101 2.2 42.2 1.0
C24 B:XZF1101 2.3 42.2 1.0
SD B:MET233 2.7 41.0 1.0
CB B:ALA529 3.8 46.1 1.0
S03 B:XZF1101 3.9 42.2 1.0
CA B:ALA529 3.9 46.1 1.0
CE B:MET233 3.9 41.0 1.0
O B:ALA529 4.0 46.1 1.0
CG B:MET233 4.1 41.0 1.0
CG2 B:ILE532 4.4 39.3 1.0
CB B:ILE532 4.4 39.3 1.0
C B:ALA529 4.5 46.1 1.0
CB B:MET233 4.5 41.0 1.0
C18 B:XZF1101 4.6 42.2 1.0
N B:SER533 4.9 37.7 1.0

Fluorine binding site 6 out of 6 in 8fhq

Go back to Fluorine Binding Sites List in 8fhq
Fluorine binding site 6 out of 6 in the Cryo-Em Structure of Human Ncc (Class 3-2)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Cryo-Em Structure of Human Ncc (Class 3-2) within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F1101

b:42.2
occ:1.00
F07 B:XZF1101 0.0 42.2 1.0
C25 B:XZF1101 1.4 42.2 1.0
F06 B:XZF1101 2.2 42.2 1.0
F05 B:XZF1101 2.2 42.2 1.0
C24 B:XZF1101 2.4 42.2 1.0
C18 B:XZF1101 3.1 42.2 1.0
S03 B:XZF1101 3.3 42.2 1.0
CG2 B:ILE532 3.5 39.3 1.0
O09 B:XZF1101 3.7 42.2 1.0
SD B:MET233 3.8 41.0 1.0
CE2 B:PHE536 4.1 36.8 1.0
CB B:ILE532 4.2 39.3 1.0
C15 B:XZF1101 4.4 42.2 1.0
CD2 B:PHE536 4.5 36.8 1.0
CA B:GLY230 4.6 35.7 1.0
C B:ILE532 4.6 39.3 1.0
N B:SER533 4.7 37.7 1.0
O B:ILE532 4.8 39.3 1.0
N12 B:XZF1101 4.8 42.2 1.0
S02 B:XZF1101 4.8 42.2 1.0
CA B:SER533 4.9 37.7 1.0

Reference:

M.Fan, J.Zhang, C.Lee, J.Zhang, L.Feng. Structure and Thiazide Inhibition Mechanism of the Human Na-Cl Cotransporter Nature 2023.
ISSN: ESSN 1476-4687
DOI: 10.1038/S41586-023-05718-0
Page generated: Wed Apr 5 02:26:27 2023

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