Fluorine in PDB 8fv2: Bromodomain of Cbp Liganded with Ccs-1477
Enzymatic activity of Bromodomain of Cbp Liganded with Ccs-1477
All present enzymatic activity of Bromodomain of Cbp Liganded with Ccs-1477:
2.3.1.48;
Protein crystallography data
The structure of Bromodomain of Cbp Liganded with Ccs-1477, PDB code: 8fv2
was solved by
E.Schonbrunn,
M.Bikowitz,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
|
Resolution Low / High (Å)
|
41.44 /
1.87
|
|
Space group
|
P 41
|
|
Cell size a, b, c (Å), α, β, γ (°)
|
79.453,
79.453,
97.127,
90,
90,
90
|
|
R / Rfree (%)
|
19 /
22.6
|
Fluorine Binding Sites:
Pages:
>>> Page 1 <<<
Page 2, Binding sites: 11 -
12;
Binding sites:
The binding sites of Fluorine atom in the Bromodomain of Cbp Liganded with Ccs-1477
(pdb code 8fv2). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 12 binding sites of Fluorine where determined in the
Bromodomain of Cbp Liganded with Ccs-1477, PDB code: 8fv2:
Jump to Fluorine binding site number:
1;
2;
3;
4;
5;
6;
7;
8;
9;
10;
Fluorine binding site 1 out
of 12 in 8fv2
Go back to
Fluorine Binding Sites List in 8fv2
Fluorine binding site 1 out
of 12 in the Bromodomain of Cbp Liganded with Ccs-1477
 Mono view
 Stereo pair view
|
|
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Bromodomain of Cbp Liganded with Ccs-1477 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F1202
b:27.3
occ:1.00
|
FBL
|
A:JHL1202
|
0.0
|
27.3
|
1.0
|
|
CBG
|
A:JHL1202
|
1.4
|
21.2
|
1.0
|
|
CBH
|
A:JHL1202
|
2.4
|
24.3
|
1.0
|
|
CBF
|
A:JHL1202
|
2.4
|
24.3
|
1.0
|
|
FBK
|
A:JHL1202
|
2.7
|
25.0
|
1.0
|
|
CG
|
A:PRO1110
|
3.3
|
19.4
|
1.0
|
|
CE2
|
A:PHE1177
|
3.3
|
23.8
|
1.0
|
|
CD2
|
A:PHE1177
|
3.4
|
23.5
|
1.0
|
|
CBE
|
A:JHL1202
|
3.6
|
26.7
|
1.0
|
|
CBI
|
A:JHL1202
|
3.6
|
26.2
|
1.0
|
|
CG2
|
A:VAL1174
|
3.9
|
22.7
|
1.0
|
|
NE
|
A:ARG1173
|
4.0
|
28.5
|
0.5
|
|
CB
|
A:ARG1173
|
4.0
|
28.2
|
0.5
|
|
CZ
|
A:ARG1173
|
4.0
|
28.8
|
0.5
|
|
CB
|
A:ARG1173
|
4.1
|
28.2
|
0.5
|
|
NH2
|
A:ARG1173
|
4.1
|
24.9
|
0.5
|
|
CBJ
|
A:JHL1202
|
4.1
|
24.2
|
1.0
|
|
CD
|
A:PRO1110
|
4.2
|
17.0
|
1.0
|
|
CB
|
A:PRO1110
|
4.4
|
16.6
|
1.0
|
|
CZ
|
A:PHE1177
|
4.4
|
26.4
|
1.0
|
|
CD
|
A:ARG1173
|
4.4
|
30.4
|
0.5
|
|
N
|
A:VAL1174
|
4.5
|
21.8
|
1.0
|
|
CG
|
A:PHE1177
|
4.6
|
23.1
|
1.0
|
|
C
|
A:ARG1173
|
4.6
|
23.2
|
0.5
|
|
CA
|
A:VAL1174
|
4.6
|
20.1
|
1.0
|
|
C
|
A:ARG1173
|
4.6
|
23.2
|
0.5
|
|
CD
|
A:ARG1173
|
4.6
|
30.7
|
0.5
|
|
NH1
|
A:ARG1173
|
4.6
|
30.8
|
0.5
|
|
NAZ
|
A:JHL1202
|
4.8
|
25.7
|
1.0
|
|
O
|
A:ARG1173
|
4.9
|
20.4
|
0.5
|
|
CG
|
A:ARG1173
|
4.9
|
31.1
|
0.5
|
|
O
|
A:ARG1173
|
4.9
|
20.4
|
0.5
|
|
CB
|
A:VAL1174
|
4.9
|
18.6
|
1.0
|
|
CG
|
A:ARG1173
|
5.0
|
29.5
|
0.5
|
|
OBM
|
A:JHL1202
|
5.0
|
22.1
|
1.0
|
|
Fluorine binding site 2 out
of 12 in 8fv2
Go back to
Fluorine Binding Sites List in 8fv2
Fluorine binding site 2 out
of 12 in the Bromodomain of Cbp Liganded with Ccs-1477
 Mono view
 Stereo pair view
|
|
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Bromodomain of Cbp Liganded with Ccs-1477 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F1202
b:25.0
occ:1.00
|
FBK
|
A:JHL1202
|
0.0
|
25.0
|
1.0
|
|
CBH
|
A:JHL1202
|
1.4
|
24.3
|
1.0
|
|
CBG
|
A:JHL1202
|
2.4
|
21.2
|
1.0
|
|
CBI
|
A:JHL1202
|
2.4
|
26.2
|
1.0
|
|
FBL
|
A:JHL1202
|
2.7
|
27.3
|
1.0
|
|
CB
|
A:LEU1109
|
3.5
|
22.4
|
1.0
|
|
CD
|
A:PRO1110
|
3.5
|
17.0
|
1.0
|
|
CG
|
A:PRO1110
|
3.5
|
19.4
|
1.0
|
|
CE2
|
A:PHE1177
|
3.5
|
23.8
|
1.0
|
|
O
|
A:PRO1106
|
3.6
|
27.2
|
1.0
|
|
CBF
|
A:JHL1202
|
3.6
|
24.3
|
1.0
|
|
CBJ
|
A:JHL1202
|
3.7
|
24.2
|
1.0
|
|
CD2
|
A:PHE1177
|
3.9
|
23.5
|
1.0
|
|
CD1
|
A:LEU1109
|
3.9
|
30.9
|
1.0
|
|
CBE
|
A:JHL1202
|
4.1
|
26.7
|
1.0
|
|
N
|
A:PRO1110
|
4.2
|
17.8
|
1.0
|
|
CG
|
A:LEU1109
|
4.3
|
26.8
|
1.0
|
|
CB
|
A:PRO1106
|
4.4
|
30.8
|
1.0
|
|
CA
|
A:LEU1109
|
4.5
|
19.1
|
1.0
|
|
NH2
|
A:ARG1173
|
4.5
|
24.9
|
0.5
|
|
C
|
A:PRO1106
|
4.6
|
23.2
|
1.0
|
|
C
|
A:LEU1109
|
4.6
|
18.3
|
1.0
|
|
CZ
|
A:ARG1173
|
4.7
|
28.8
|
0.5
|
|
NH1
|
A:ARG1173
|
4.7
|
30.8
|
0.5
|
|
CZ
|
A:PHE1177
|
4.7
|
26.4
|
1.0
|
|
CB
|
A:PRO1110
|
4.8
|
16.6
|
1.0
|
|
N
|
A:LEU1109
|
4.8
|
21.3
|
1.0
|
|
Fluorine binding site 3 out
of 12 in 8fv2
Go back to
Fluorine Binding Sites List in 8fv2
Fluorine binding site 3 out
of 12 in the Bromodomain of Cbp Liganded with Ccs-1477
 Mono view
 Stereo pair view
|
|
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Bromodomain of Cbp Liganded with Ccs-1477 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:F1204
b:26.2
occ:1.00
|
FBL
|
B:JHL1204
|
0.0
|
26.2
|
1.0
|
|
CBG
|
B:JHL1204
|
1.4
|
24.4
|
1.0
|
|
CBF
|
B:JHL1204
|
2.4
|
25.4
|
1.0
|
|
CBH
|
B:JHL1204
|
2.4
|
25.9
|
1.0
|
|
FBK
|
B:JHL1204
|
2.8
|
22.7
|
1.0
|
|
CE2
|
B:PHE1177
|
3.3
|
24.4
|
1.0
|
|
CD2
|
B:PHE1177
|
3.4
|
20.0
|
1.0
|
|
CG
|
B:PRO1110
|
3.4
|
16.1
|
1.0
|
|
CBE
|
B:JHL1204
|
3.6
|
26.6
|
1.0
|
|
CBI
|
B:JHL1204
|
3.6
|
26.4
|
1.0
|
|
CG2
|
B:VAL1174
|
3.8
|
22.0
|
1.0
|
|
CB
|
B:ARG1173
|
3.9
|
27.9
|
1.0
|
|
NE
|
B:ARG1173
|
3.9
|
42.7
|
1.0
|
|
CZ
|
B:ARG1173
|
4.1
|
39.3
|
1.0
|
|
CBJ
|
B:JHL1204
|
4.1
|
24.7
|
1.0
|
|
CD
|
B:ARG1173
|
4.2
|
34.2
|
1.0
|
|
CZ
|
B:PHE1177
|
4.3
|
25.6
|
1.0
|
|
N
|
B:VAL1174
|
4.3
|
22.3
|
1.0
|
|
CD
|
B:PRO1110
|
4.3
|
16.6
|
1.0
|
|
CG
|
B:PHE1177
|
4.4
|
20.3
|
1.0
|
|
NH1
|
B:ARG1173
|
4.4
|
33.4
|
1.0
|
|
CA
|
B:VAL1174
|
4.4
|
18.0
|
1.0
|
|
NH2
|
B:ARG1173
|
4.4
|
39.6
|
1.0
|
|
C
|
B:ARG1173
|
4.5
|
26.0
|
1.0
|
|
CG
|
B:ARG1173
|
4.5
|
37.8
|
1.0
|
|
CB
|
B:PRO1110
|
4.5
|
17.8
|
1.0
|
|
CB
|
B:VAL1174
|
4.8
|
22.3
|
1.0
|
|
O
|
B:ARG1173
|
4.8
|
22.2
|
1.0
|
|
NAZ
|
B:JHL1204
|
4.8
|
26.5
|
1.0
|
|
CA
|
B:ARG1173
|
4.9
|
27.0
|
1.0
|
|
OBM
|
B:JHL1204
|
5.0
|
23.7
|
1.0
|
|
Fluorine binding site 4 out
of 12 in 8fv2
Go back to
Fluorine Binding Sites List in 8fv2
Fluorine binding site 4 out
of 12 in the Bromodomain of Cbp Liganded with Ccs-1477
 Mono view
 Stereo pair view
|
|
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Bromodomain of Cbp Liganded with Ccs-1477 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:F1204
b:22.7
occ:1.00
|
FBK
|
B:JHL1204
|
0.0
|
22.7
|
1.0
|
|
CBH
|
B:JHL1204
|
1.4
|
25.9
|
1.0
|
|
CBG
|
B:JHL1204
|
2.4
|
24.4
|
1.0
|
|
CBI
|
B:JHL1204
|
2.4
|
26.4
|
1.0
|
|
FBL
|
B:JHL1204
|
2.8
|
26.2
|
1.0
|
|
CD
|
B:PRO1110
|
3.4
|
16.6
|
1.0
|
|
CG
|
B:PRO1110
|
3.4
|
16.1
|
1.0
|
|
CE2
|
B:PHE1177
|
3.4
|
24.4
|
1.0
|
|
O
|
B:PRO1106
|
3.5
|
22.2
|
1.0
|
|
CB
|
B:LEU1109
|
3.6
|
23.0
|
1.0
|
|
CBF
|
B:JHL1204
|
3.7
|
25.4
|
1.0
|
|
CBJ
|
B:JHL1204
|
3.7
|
24.7
|
1.0
|
|
CD2
|
B:PHE1177
|
3.8
|
20.0
|
1.0
|
|
CD1
|
B:LEU1109
|
4.0
|
20.9
|
1.0
|
|
NH2
|
B:ARG1173
|
4.1
|
39.6
|
1.0
|
|
CBE
|
B:JHL1204
|
4.2
|
26.6
|
1.0
|
|
N
|
B:PRO1110
|
4.2
|
16.8
|
1.0
|
|
CB
|
B:PRO1106
|
4.3
|
28.2
|
1.0
|
|
CG
|
B:LEU1109
|
4.3
|
22.1
|
1.0
|
|
C
|
B:PRO1106
|
4.4
|
23.7
|
1.0
|
|
O
|
B:HOH1383
|
4.5
|
30.9
|
1.0
|
|
CA
|
B:LEU1109
|
4.5
|
16.9
|
1.0
|
|
CZ
|
B:ARG1173
|
4.5
|
39.3
|
1.0
|
|
C
|
B:LEU1109
|
4.7
|
17.7
|
1.0
|
|
CZ
|
B:PHE1177
|
4.7
|
25.6
|
1.0
|
|
N
|
B:LEU1109
|
4.7
|
18.0
|
1.0
|
|
CB
|
B:PRO1110
|
4.8
|
17.8
|
1.0
|
|
CA
|
B:PRO1106
|
4.9
|
25.2
|
1.0
|
|
NE
|
B:ARG1173
|
5.0
|
42.7
|
1.0
|
|
Fluorine binding site 5 out
of 12 in 8fv2
Go back to
Fluorine Binding Sites List in 8fv2
Fluorine binding site 5 out
of 12 in the Bromodomain of Cbp Liganded with Ccs-1477
 Mono view
 Stereo pair view
|
|
A full contact list of Fluorine with other atoms in the F binding
site number 5 of Bromodomain of Cbp Liganded with Ccs-1477 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:F1205
b:33.1
occ:1.00
|
FBL
|
B:JHL1205
|
0.0
|
33.1
|
1.0
|
|
CBG
|
B:JHL1205
|
1.4
|
23.7
|
1.0
|
|
CBF
|
B:JHL1205
|
2.4
|
21.4
|
1.0
|
|
CBH
|
B:JHL1205
|
2.4
|
20.5
|
1.0
|
|
FBK
|
B:JHL1205
|
2.7
|
26.0
|
1.0
|
|
O
|
B:GLU1089
|
3.1
|
16.0
|
1.0
|
|
C
|
B:GLU1089
|
3.3
|
16.3
|
1.0
|
|
N
|
B:LEU1090
|
3.5
|
13.6
|
1.0
|
|
CBE
|
B:JHL1205
|
3.6
|
25.8
|
1.0
|
|
CBI
|
B:JHL1205
|
3.6
|
19.6
|
1.0
|
|
CA
|
B:LEU1090
|
3.7
|
14.7
|
1.0
|
|
CD2
|
B:PHE1085
|
3.7
|
20.0
|
1.0
|
|
CB
|
B:ALA1093
|
3.8
|
13.8
|
1.0
|
|
CB
|
B:GLU1089
|
3.8
|
18.7
|
1.0
|
|
CD2
|
B:LEU1090
|
3.8
|
15.5
|
1.0
|
|
CBJ
|
B:JHL1205
|
4.1
|
18.1
|
1.0
|
|
CA
|
B:GLU1089
|
4.1
|
17.3
|
1.0
|
|
CG
|
B:LEU1090
|
4.3
|
14.2
|
1.0
|
|
CE2
|
B:PHE1085
|
4.3
|
22.4
|
1.0
|
|
CAS
|
B:JHL1205
|
4.3
|
18.0
|
1.0
|
|
CB
|
B:LEU1090
|
4.6
|
13.7
|
1.0
|
|
CG
|
B:PHE1085
|
4.7
|
21.4
|
1.0
|
|
C
|
B:LEU1090
|
4.7
|
15.4
|
1.0
|
|
NAZ
|
B:JHL1205
|
4.8
|
23.2
|
1.0
|
|
CB
|
B:PHE1085
|
4.9
|
21.6
|
1.0
|
|
CAT
|
B:JHL1205
|
5.0
|
15.4
|
1.0
|
|
O
|
B:LEU1090
|
5.0
|
14.2
|
1.0
|
|
N
|
B:ALA1093
|
5.0
|
13.9
|
1.0
|
|
Fluorine binding site 6 out
of 12 in 8fv2
Go back to
Fluorine Binding Sites List in 8fv2
Fluorine binding site 6 out
of 12 in the Bromodomain of Cbp Liganded with Ccs-1477
 Mono view
 Stereo pair view
|
|
A full contact list of Fluorine with other atoms in the F binding
site number 6 of Bromodomain of Cbp Liganded with Ccs-1477 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:F1205
b:26.0
occ:1.00
|
FBK
|
B:JHL1205
|
0.0
|
26.0
|
1.0
|
|
CBH
|
B:JHL1205
|
1.4
|
20.5
|
1.0
|
|
CBG
|
B:JHL1205
|
2.4
|
23.7
|
1.0
|
|
CBI
|
B:JHL1205
|
2.4
|
19.6
|
1.0
|
|
FBL
|
B:JHL1205
|
2.7
|
33.1
|
1.0
|
|
CG
|
B:PRO1150
|
3.2
|
17.0
|
1.0
|
|
CB
|
B:ALA1093
|
3.4
|
13.8
|
1.0
|
|
CD2
|
B:LEU1090
|
3.5
|
15.5
|
1.0
|
|
CBF
|
B:JHL1205
|
3.6
|
21.4
|
1.0
|
|
CBJ
|
B:JHL1205
|
3.6
|
18.1
|
1.0
|
|
CG
|
B:LEU1094
|
3.8
|
15.6
|
1.0
|
|
CB
|
B:PRO1150
|
3.9
|
16.2
|
1.0
|
|
CD2
|
B:LEU1094
|
3.9
|
13.9
|
1.0
|
|
CD1
|
B:LEU1094
|
4.0
|
14.4
|
1.0
|
|
CBE
|
B:JHL1205
|
4.1
|
25.8
|
1.0
|
|
CA
|
B:LEU1090
|
4.4
|
14.7
|
1.0
|
|
CG1
|
B:VAL1192
|
4.4
|
14.9
|
1.0
|
|
CD
|
B:PRO1150
|
4.4
|
13.9
|
1.0
|
|
CD2
|
B:PHE1085
|
4.5
|
20.0
|
1.0
|
|
CE2
|
B:PHE1085
|
4.7
|
22.4
|
1.0
|
|
CA
|
B:PRO1150
|
4.7
|
15.1
|
1.0
|
|
CG
|
B:LEU1090
|
4.7
|
14.2
|
1.0
|
|
CA
|
B:ALA1093
|
4.7
|
13.8
|
1.0
|
|
O
|
B:GLU1089
|
4.7
|
16.0
|
1.0
|
|
O
|
B:LEU1090
|
4.8
|
14.2
|
1.0
|
|
CB
|
B:LEU1090
|
4.9
|
13.7
|
1.0
|
|
C
|
B:ALA1093
|
4.9
|
14.1
|
1.0
|
|
N
|
B:PRO1150
|
5.0
|
13.9
|
1.0
|
|
Fluorine binding site 7 out
of 12 in 8fv2
Go back to
Fluorine Binding Sites List in 8fv2
Fluorine binding site 7 out
of 12 in the Bromodomain of Cbp Liganded with Ccs-1477
 Mono view
 Stereo pair view
|
|
A full contact list of Fluorine with other atoms in the F binding
site number 7 of Bromodomain of Cbp Liganded with Ccs-1477 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:F1201
b:24.3
occ:1.00
|
FBL
|
C:JHL1201
|
0.0
|
24.3
|
1.0
|
|
CBG
|
C:JHL1201
|
1.4
|
23.8
|
1.0
|
|
CBH
|
C:JHL1201
|
2.4
|
22.7
|
1.0
|
|
CBF
|
C:JHL1201
|
2.4
|
26.4
|
1.0
|
|
FBK
|
C:JHL1201
|
2.7
|
24.5
|
1.0
|
|
CE2
|
C:PHE1177
|
3.3
|
21.6
|
1.0
|
|
CG
|
C:PRO1110
|
3.3
|
17.0
|
1.0
|
|
CD2
|
C:PHE1177
|
3.3
|
19.4
|
1.0
|
|
CBI
|
C:JHL1201
|
3.6
|
27.6
|
1.0
|
|
CBE
|
C:JHL1201
|
3.6
|
24.6
|
1.0
|
|
CG2
|
C:VAL1174
|
3.9
|
21.9
|
1.0
|
|
CB
|
C:ARG1173
|
3.9
|
26.4
|
1.0
|
|
NE
|
C:ARG1173
|
4.0
|
41.3
|
1.0
|
|
CZ
|
C:ARG1173
|
4.1
|
41.8
|
1.0
|
|
CBJ
|
C:JHL1201
|
4.1
|
22.8
|
1.0
|
|
CD
|
C:PRO1110
|
4.2
|
16.5
|
1.0
|
|
CZ
|
C:PHE1177
|
4.2
|
24.0
|
1.0
|
|
CD
|
C:ARG1173
|
4.3
|
33.3
|
1.0
|
|
NH1
|
C:ARG1173
|
4.3
|
31.0
|
1.0
|
|
CG
|
C:PHE1177
|
4.3
|
21.2
|
1.0
|
|
N
|
C:VAL1174
|
4.4
|
21.6
|
1.0
|
|
C
|
C:ARG1173
|
4.5
|
26.2
|
1.0
|
|
CA
|
C:VAL1174
|
4.5
|
19.0
|
1.0
|
|
CB
|
C:PRO1110
|
4.5
|
17.4
|
1.0
|
|
NH2
|
C:ARG1173
|
4.5
|
36.2
|
1.0
|
|
CG
|
C:ARG1173
|
4.6
|
36.4
|
1.0
|
|
O
|
C:ARG1173
|
4.8
|
23.0
|
1.0
|
|
NAZ
|
C:JHL1201
|
4.8
|
28.1
|
1.0
|
|
CB
|
C:VAL1174
|
4.8
|
19.8
|
1.0
|
|
CA
|
C:ARG1173
|
4.9
|
26.2
|
1.0
|
|
Fluorine binding site 8 out
of 12 in 8fv2
Go back to
Fluorine Binding Sites List in 8fv2
Fluorine binding site 8 out
of 12 in the Bromodomain of Cbp Liganded with Ccs-1477
 Mono view
 Stereo pair view
|
|
A full contact list of Fluorine with other atoms in the F binding
site number 8 of Bromodomain of Cbp Liganded with Ccs-1477 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:F1201
b:24.5
occ:1.00
|
FBK
|
C:JHL1201
|
0.0
|
24.5
|
1.0
|
|
CBH
|
C:JHL1201
|
1.4
|
22.7
|
1.0
|
|
CBG
|
C:JHL1201
|
2.4
|
23.8
|
1.0
|
|
CBI
|
C:JHL1201
|
2.4
|
27.6
|
1.0
|
|
FBL
|
C:JHL1201
|
2.7
|
24.3
|
1.0
|
|
CD
|
C:PRO1110
|
3.4
|
16.5
|
1.0
|
|
CE2
|
C:PHE1177
|
3.4
|
21.6
|
1.0
|
|
O
|
C:PRO1106
|
3.5
|
20.0
|
1.0
|
|
CG
|
C:PRO1110
|
3.5
|
17.0
|
1.0
|
|
CB
|
C:LEU1109
|
3.6
|
23.1
|
1.0
|
|
CBF
|
C:JHL1201
|
3.7
|
26.4
|
1.0
|
|
CBJ
|
C:JHL1201
|
3.7
|
22.8
|
1.0
|
|
CD2
|
C:PHE1177
|
3.8
|
19.4
|
1.0
|
|
CD1
|
C:LEU1109
|
4.0
|
22.4
|
1.0
|
|
CBE
|
C:JHL1201
|
4.1
|
24.6
|
1.0
|
|
N
|
C:PRO1110
|
4.2
|
17.2
|
1.0
|
|
NH2
|
C:ARG1173
|
4.2
|
36.2
|
1.0
|
|
CB
|
C:PRO1106
|
4.3
|
24.0
|
1.0
|
|
CG
|
C:LEU1109
|
4.3
|
21.6
|
1.0
|
|
C
|
C:PRO1106
|
4.4
|
23.2
|
1.0
|
|
CA
|
C:LEU1109
|
4.5
|
19.0
|
1.0
|
|
CZ
|
C:ARG1173
|
4.5
|
41.8
|
1.0
|
|
C
|
C:LEU1109
|
4.6
|
16.4
|
1.0
|
|
CZ
|
C:PHE1177
|
4.6
|
24.0
|
1.0
|
|
N
|
C:LEU1109
|
4.7
|
16.9
|
1.0
|
|
CB
|
C:PRO1110
|
4.8
|
17.4
|
1.0
|
|
NH1
|
C:ARG1173
|
4.8
|
31.0
|
1.0
|
|
CA
|
C:PRO1106
|
4.9
|
25.2
|
1.0
|
|
Fluorine binding site 9 out
of 12 in 8fv2
Go back to
Fluorine Binding Sites List in 8fv2
Fluorine binding site 9 out
of 12 in the Bromodomain of Cbp Liganded with Ccs-1477
 Mono view
 Stereo pair view
|
|
A full contact list of Fluorine with other atoms in the F binding
site number 9 of Bromodomain of Cbp Liganded with Ccs-1477 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:F1202
b:30.2
occ:1.00
|
FBL
|
C:JHL1202
|
0.0
|
30.2
|
1.0
|
|
CBG
|
C:JHL1202
|
1.4
|
22.4
|
1.0
|
|
CBF
|
C:JHL1202
|
2.4
|
21.6
|
1.0
|
|
CBH
|
C:JHL1202
|
2.4
|
22.5
|
1.0
|
|
FBK
|
C:JHL1202
|
2.6
|
23.6
|
1.0
|
|
O
|
C:GLU1089
|
3.0
|
14.6
|
1.0
|
|
C
|
C:GLU1089
|
3.3
|
14.7
|
1.0
|
|
N
|
C:LEU1090
|
3.5
|
14.2
|
1.0
|
|
CBE
|
C:JHL1202
|
3.6
|
25.6
|
1.0
|
|
CB
|
C:ALA1093
|
3.6
|
13.5
|
1.0
|
|
CA
|
C:LEU1090
|
3.6
|
15.7
|
1.0
|
|
CBI
|
C:JHL1202
|
3.7
|
22.2
|
1.0
|
|
CD2
|
C:PHE1085
|
3.7
|
19.2
|
1.0
|
|
CD2
|
C:LEU1090
|
3.8
|
14.5
|
1.0
|
|
CB
|
C:GLU1089
|
3.8
|
17.0
|
1.0
|
|
CBJ
|
C:JHL1202
|
4.1
|
19.4
|
1.0
|
|
CA
|
C:GLU1089
|
4.2
|
18.7
|
1.0
|
|
CG
|
C:LEU1090
|
4.3
|
15.2
|
1.0
|
|
CAS
|
C:JHL1202
|
4.3
|
16.9
|
1.0
|
|
CE2
|
C:PHE1085
|
4.3
|
22.7
|
1.0
|
|
CB
|
C:LEU1090
|
4.6
|
14.2
|
1.0
|
|
C
|
C:LEU1090
|
4.7
|
15.4
|
1.0
|
|
CG
|
C:PHE1085
|
4.7
|
20.5
|
1.0
|
|
NAZ
|
C:JHL1202
|
4.8
|
26.6
|
1.0
|
|
CB
|
C:PHE1085
|
4.9
|
19.8
|
1.0
|
|
CA
|
C:ALA1093
|
4.9
|
13.5
|
1.0
|
|
N
|
C:ALA1093
|
4.9
|
13.4
|
1.0
|
|
O
|
C:LEU1090
|
4.9
|
14.1
|
1.0
|
|
CG
|
C:PRO1150
|
5.0
|
13.7
|
1.0
|
|
Fluorine binding site 10 out
of 12 in 8fv2
Go back to
Fluorine Binding Sites List in 8fv2
Fluorine binding site 10 out
of 12 in the Bromodomain of Cbp Liganded with Ccs-1477
 Mono view
 Stereo pair view
|
|
A full contact list of Fluorine with other atoms in the F binding
site number 10 of Bromodomain of Cbp Liganded with Ccs-1477 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:F1202
b:23.6
occ:1.00
|
FBK
|
C:JHL1202
|
0.0
|
23.6
|
1.0
|
|
CBH
|
C:JHL1202
|
1.4
|
22.5
|
1.0
|
|
CBG
|
C:JHL1202
|
2.3
|
22.4
|
1.0
|
|
CBI
|
C:JHL1202
|
2.4
|
22.2
|
1.0
|
|
FBL
|
C:JHL1202
|
2.6
|
30.2
|
1.0
|
|
CG
|
C:PRO1150
|
3.3
|
13.7
|
1.0
|
|
CB
|
C:ALA1093
|
3.3
|
13.5
|
1.0
|
|
CD2
|
C:LEU1090
|
3.6
|
14.5
|
1.0
|
|
CBF
|
C:JHL1202
|
3.6
|
21.6
|
1.0
|
|
CBJ
|
C:JHL1202
|
3.6
|
19.4
|
1.0
|
|
CG
|
C:LEU1094
|
3.8
|
16.3
|
1.0
|
|
CD2
|
C:LEU1094
|
3.8
|
13.6
|
1.0
|
|
CB
|
C:PRO1150
|
3.9
|
13.7
|
1.0
|
|
CD1
|
C:LEU1094
|
4.0
|
14.0
|
1.0
|
|
CBE
|
C:JHL1202
|
4.1
|
25.6
|
1.0
|
|
CG1
|
C:VAL1192
|
4.3
|
13.7
|
1.0
|
|
CA
|
C:LEU1090
|
4.4
|
15.7
|
1.0
|
|
CD
|
C:PRO1150
|
4.5
|
13.7
|
1.0
|
|
CD2
|
C:PHE1085
|
4.6
|
19.2
|
1.0
|
|
CA
|
C:ALA1093
|
4.7
|
13.5
|
1.0
|
|
CE2
|
C:PHE1085
|
4.7
|
22.7
|
1.0
|
|
CA
|
C:PRO1150
|
4.7
|
13.7
|
1.0
|
|
O
|
C:GLU1089
|
4.8
|
14.6
|
1.0
|
|
CG
|
C:LEU1090
|
4.8
|
15.2
|
1.0
|
|
O
|
C:LEU1090
|
4.8
|
14.1
|
1.0
|
|
C
|
C:ALA1093
|
4.9
|
13.6
|
1.0
|
|
CB
|
C:LEU1090
|
5.0
|
14.2
|
1.0
|
|
N
|
C:LEU1094
|
5.0
|
16.2
|
1.0
|
|
Reference:
E.Schonbrunn,
M.Bikowitz.
Group 3 Medulloblastoma Transcriptional Networks Are Sensitive to EP300/Cbp Bromodomain Inhibition To Be Published.
Page generated: Fri Aug 2 19:26:19 2024
|
