Fluorine in PDB 8gd4: Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 Complexed with Dmfo Inhibitor 6
Protein crystallography data
The structure of Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 Complexed with Dmfo Inhibitor 6, PDB code: 8gd4
was solved by
P.R.Watson,
A.D.Craigin,
D.W.Christianson,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 29.56 / 2.00 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 74.803, 92.364, 96.474, 90, 90, 90 |
| R / Rfree (%) | 18.5 / 22.2 |
Other elements in 8gd4:
The structure of Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 Complexed with Dmfo Inhibitor 6 also contains other interesting chemical elements:
| Potassium | (K) | 4 atoms |
| Zinc | (Zn) | 2 atoms |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 Complexed with Dmfo Inhibitor 6
(pdb code 8gd4). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 Complexed with Dmfo Inhibitor 6, PDB code: 8gd4:
Jump to Fluorine binding site number: 1; 2; 3; 4;
In total 4 binding sites of Fluorine where determined in the Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 Complexed with Dmfo Inhibitor 6, PDB code: 8gd4:
Jump to Fluorine binding site number: 1; 2; 3; 4;
Fluorine binding site 1 out of 4 in 8gd4
Go back to
Fluorine Binding Sites List in 8gd4
Fluorine binding site 1 out
of 4 in the Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 Complexed with Dmfo Inhibitor 6
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 Complexed with Dmfo Inhibitor 6 within 5.0Å range:
|
Fluorine binding site 2 out of 4 in 8gd4
Go back to
Fluorine Binding Sites List in 8gd4
Fluorine binding site 2 out
of 4 in the Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 Complexed with Dmfo Inhibitor 6
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 Complexed with Dmfo Inhibitor 6 within 5.0Å range:
|
Fluorine binding site 3 out of 4 in 8gd4
Go back to
Fluorine Binding Sites List in 8gd4
Fluorine binding site 3 out
of 4 in the Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 Complexed with Dmfo Inhibitor 6
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 Complexed with Dmfo Inhibitor 6 within 5.0Å range:
|
Fluorine binding site 4 out of 4 in 8gd4
Go back to
Fluorine Binding Sites List in 8gd4
Fluorine binding site 4 out
of 4 in the Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 Complexed with Dmfo Inhibitor 6
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 Complexed with Dmfo Inhibitor 6 within 5.0Å range:
|
Reference:
B.Konig,
P.R.Watson,
N.Rebing,
A.D.Craigin,
L.Schaker-Hubner,
D.W.Christianson,
F.K.Hansen.
Difluoromethyl-1,3,4-Oxadiazoles Are Selective, Mechanism-Based, and Essentially Irreversible Inhibitors of Histone Deacetylase 6 To Be Published.
Page generated: Fri Aug 2 19:46:05 2024
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