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Fluorine in PDB 8god: Co-Crystal Structure of Human Protein-Arginine Deiminase Type-4 (PAD4) with Small Molecule Inhibitor Jbi-589
Enzymatic activity of Co-Crystal Structure of Human Protein-Arginine Deiminase Type-4 (PAD4) with Small Molecule Inhibitor Jbi-589
All present enzymatic activity of Co-Crystal Structure of Human Protein-Arginine Deiminase Type-4 (PAD4) with Small Molecule Inhibitor Jbi-589:
3.5.3.15;
3.5.3.15;
Protein crystallography data
The structure of Co-Crystal Structure of Human Protein-Arginine Deiminase Type-4 (PAD4) with Small Molecule Inhibitor Jbi-589, PDB code: 8god
was solved by
S.Swaminathan,
S.Birudukota,
K.Vaithilingam,
S.Kandan,
K.Asaithambi,
N.Kathiresan,
R.Gosu,
S.Rajagopal,
N.Sadhu,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 42.90 / 2.88 |
| Space group | I 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 111.456, 60.879, 127.097, 90, 104.59, 90 |
| R / Rfree (%) | 20.5 / 27.3 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Co-Crystal Structure of Human Protein-Arginine Deiminase Type-4 (PAD4) with Small Molecule Inhibitor Jbi-589
(pdb code 8god). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Co-Crystal Structure of Human Protein-Arginine Deiminase Type-4 (PAD4) with Small Molecule Inhibitor Jbi-589, PDB code: 8god:
In total only one binding site of Fluorine was determined in the Co-Crystal Structure of Human Protein-Arginine Deiminase Type-4 (PAD4) with Small Molecule Inhibitor Jbi-589, PDB code: 8god:
Fluorine binding site 1 out of 1 in 8god
Go back to
Fluorine Binding Sites List in 8god
Fluorine binding site 1 out
of 1 in the Co-Crystal Structure of Human Protein-Arginine Deiminase Type-4 (PAD4) with Small Molecule Inhibitor Jbi-589
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Co-Crystal Structure of Human Protein-Arginine Deiminase Type-4 (PAD4) with Small Molecule Inhibitor Jbi-589 within 5.0Å range:
|
Reference:
C.Gajendran,
S.Fukui,
N.M.Sadhu,
M.Zainuddin,
S.Rajagopal,
R.Gosu,
S.Gutch,
S.Fukui,
C.E.Sheehy,
L.Chu,
S.Vishwakarma,
D.A.Jeyaraj,
G.Hallur,
D.D.Wagner,
D.Sivanandhan.
Alleviation of Arthritis Through Prevention of Neutrophil Extracellular Traps By An Orally Available Inhibitor of Protein Arginine Deiminase 4. Sci Rep V. 13 3189 2023.
ISSN: ESSN 2045-2322
PubMed: 36823444
DOI: 10.1038/S41598-023-30246-2
Page generated: Fri Aug 2 19:56:05 2024
ISSN: ESSN 2045-2322
PubMed: 36823444
DOI: 10.1038/S41598-023-30246-2
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