Atomistry » Fluorine » PDB 8iqn-8jrl » 8jpc
Atomistry »
  Fluorine »
    PDB 8iqn-8jrl »
      8jpc »

Fluorine in PDB 8jpc: Cryo-Em Structure of NTSR1-GRK2-Galpha(Q) Complexes 2

Enzymatic activity of Cryo-Em Structure of NTSR1-GRK2-Galpha(Q) Complexes 2

All present enzymatic activity of Cryo-Em Structure of NTSR1-GRK2-Galpha(Q) Complexes 2:
2.7.11.15;

Other elements in 8jpc:

The structure of Cryo-Em Structure of NTSR1-GRK2-Galpha(Q) Complexes 2 also contains other interesting chemical elements:

Aluminium (Al) 1 atom
Magnesium (Mg) 1 atom

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Cryo-Em Structure of NTSR1-GRK2-Galpha(Q) Complexes 2 (pdb code 8jpc). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 5 binding sites of Fluorine where determined in the Cryo-Em Structure of NTSR1-GRK2-Galpha(Q) Complexes 2, PDB code: 8jpc:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5;

Fluorine binding site 1 out of 5 in 8jpc

Go back to Fluorine Binding Sites List in 8jpc
Fluorine binding site 1 out of 5 in the Cryo-Em Structure of NTSR1-GRK2-Galpha(Q) Complexes 2


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of NTSR1-GRK2-Galpha(Q) Complexes 2 within 5.0Å range:
probe atom residue distance (Å) B Occ
R:F501

b:54.0
occ:1.00
 F1 R:SRW501 0.0 54.0 1.0
C24 R:SRW501 1.4 40.6 1.0
C14 R:SRW501 2.4 39.7 1.0
C26 R:SRW501 2.4 50.7 1.0
C25 R:SRW501 2.4 51.2 1.0
CD R:ARG166 2.8 48.1 1.0
N2 R:SRW501 3.0 47.8 1.0
NE R:ARG166 3.0 44.9 1.0
N3 R:SRW501 3.4 49.2 1.0
CG R:ARG166 3.8 43.4 1.0
CB R:ARG166 3.9 36.5 1.0
CZ R:ARG166 4.0 37.1 1.0
C13 R:SRW501 4.1 45.0 1.0
CG2 R:ILE259 4.5 53.5 1.0
C15 R:SRW501 4.5 52.1 1.0
CD2 R:LEU305 4.5 33.9 1.0
NH2 R:ARG166 4.6 31.6 1.0
CD1 R:LEU305 4.6 34.3 1.0
C16 R:SRW501 4.7 41.3 1.0
NH1 R:ARG166 4.7 34.0 1.0
CG R:LEU305 4.9 28.4 1.0

Fluorine binding site 2 out of 5 in 8jpc

Go back to Fluorine Binding Sites List in 8jpc
Fluorine binding site 2 out of 5 in the Cryo-Em Structure of NTSR1-GRK2-Galpha(Q) Complexes 2


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Cryo-Em Structure of NTSR1-GRK2-Galpha(Q) Complexes 2 within 5.0Å range:
probe atom residue distance (Å) B Occ
Q:F403

b:96.7
occ:1.00
 F1 Q:ALF403 0.0 96.7 1.0
AL Q:ALF403 1.8 96.7 1.0
F4 Q:ALF403 2.5 96.7 1.0
F3 Q:ALF403 2.5 96.7 1.0
NH2 Q:ARG183 2.8 103.4 1.0
O2B Q:GDP401 2.8 99.5 1.0
O2A Q:GDP401 2.8 99.5 1.0
NH1 Q:ARG183 3.1 103.4 1.0
CZ Q:ARG183 3.2 103.4 1.0
F2 Q:ALF403 3.6 96.7 1.0
CA Q:PRO185 3.8 95.8 1.0
O3B Q:GDP401 3.9 99.5 1.0
PB Q:GDP401 3.9 99.5 1.0
N Q:GLU49 4.0 101.9 1.0
PA Q:GDP401 4.2 99.5 1.0
N Q:THR186 4.2 89.8 1.0
MG Q:MG402 4.3 87.4 1.0
NE Q:ARG183 4.3 103.4 1.0
CA Q:GLU49 4.4 101.9 1.0
CB Q:PRO185 4.4 95.8 1.0
O3A Q:GDP401 4.5 99.5 1.0
C Q:PRO185 4.5 95.8 1.0
N Q:PRO185 4.6 95.8 1.0
O Q:VAL184 4.7 101.1 1.0
CG Q:GLU49 5.0 101.9 1.0
C Q:VAL184 5.0 101.1 1.0
C Q:GLY48 5.0 92.4 1.0

Fluorine binding site 3 out of 5 in 8jpc

Go back to Fluorine Binding Sites List in 8jpc
Fluorine binding site 3 out of 5 in the Cryo-Em Structure of NTSR1-GRK2-Galpha(Q) Complexes 2


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Cryo-Em Structure of NTSR1-GRK2-Galpha(Q) Complexes 2 within 5.0Å range:
probe atom residue distance (Å) B Occ
Q:F403

b:96.7
occ:1.00
 F2 Q:ALF403 0.0 96.7 1.0
AL Q:ALF403 1.8 96.7 1.0
N Q:GLY208 2.4 88.3 1.0
F3 Q:ALF403 2.5 96.7 1.0
F4 Q:ALF403 2.5 96.7 1.0
CA Q:GLY207 3.1 80.2 1.0
C Q:GLY207 3.2 80.2 1.0
O2B Q:GDP401 3.3 99.5 1.0
CA Q:GLY208 3.4 88.3 1.0
F1 Q:ALF403 3.6 96.7 1.0
NZ Q:LYS52 3.8 94.6 1.0
O3B Q:GDP401 3.9 99.5 1.0
O Q:VAL206 3.9 80.0 1.0
CE Q:LYS52 4.0 94.6 1.0
PB Q:GDP401 4.1 99.5 1.0
MG Q:MG402 4.2 87.4 1.0
CA Q:GLY48 4.2 92.4 1.0
O Q:THR186 4.2 89.8 1.0
N Q:GLN209 4.3 89.5 1.0
C Q:GLY208 4.3 88.3 1.0
N Q:GLY207 4.3 80.2 1.0
O Q:GLY207 4.3 80.2 1.0
O1B Q:GDP401 4.3 99.5 1.0
C Q:VAL206 4.6 80.0 1.0
N Q:GLU49 4.7 101.9 1.0
CB Q:THR186 4.8 89.8 1.0
N Q:THR186 4.8 89.8 1.0
C Q:THR186 4.9 89.8 1.0

Fluorine binding site 4 out of 5 in 8jpc

Go back to Fluorine Binding Sites List in 8jpc
Fluorine binding site 4 out of 5 in the Cryo-Em Structure of NTSR1-GRK2-Galpha(Q) Complexes 2


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Cryo-Em Structure of NTSR1-GRK2-Galpha(Q) Complexes 2 within 5.0Å range:
probe atom residue distance (Å) B Occ
Q:F403

b:96.7
occ:1.00
 F3 Q:ALF403 0.0 96.7 1.0
AL Q:ALF403 1.8 96.7 1.0
MG Q:MG402 2.3 87.4 1.0
F2 Q:ALF403 2.5 96.7 1.0
F1 Q:ALF403 2.5 96.7 1.0
N Q:THR186 2.8 89.8 1.0
O3B Q:GDP401 2.8 99.5 1.0
CB Q:THR186 3.2 89.8 1.0
O2B Q:GDP401 3.3 99.5 1.0
CA Q:THR186 3.4 89.8 1.0
OG1 Q:THR186 3.5 89.8 1.0
F4 Q:ALF403 3.6 96.7 1.0
PB Q:GDP401 3.7 99.5 1.0
O Q:THR186 3.7 89.8 1.0
C Q:PRO185 3.8 95.8 1.0
O2A Q:GDP401 3.9 99.5 1.0
C Q:THR186 3.9 89.8 1.0
CA Q:PRO185 4.0 95.8 1.0
OG Q:SER53 4.2 91.8 1.0
O Q:VAL184 4.3 101.1 1.0
CG2 Q:THR186 4.5 89.8 1.0
O1B Q:GDP401 4.6 99.5 1.0
CA Q:GLY207 4.7 80.2 1.0
O3A Q:GDP401 4.8 99.5 1.0
PA Q:GDP401 4.9 99.5 1.0
N Q:GLY208 4.9 88.3 1.0
O Q:PRO185 4.9 95.8 1.0
CB Q:PRO185 4.9 95.8 1.0

Fluorine binding site 5 out of 5 in 8jpc

Go back to Fluorine Binding Sites List in 8jpc
Fluorine binding site 5 out of 5 in the Cryo-Em Structure of NTSR1-GRK2-Galpha(Q) Complexes 2


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Cryo-Em Structure of NTSR1-GRK2-Galpha(Q) Complexes 2 within 5.0Å range:
probe atom residue distance (Å) B Occ
Q:F403

b:96.7
occ:1.00
 F4 Q:ALF403 0.0 96.7 1.0
AL Q:ALF403 1.8 96.7 1.0
F1 Q:ALF403 2.5 96.7 1.0
F2 Q:ALF403 2.5 96.7 1.0
N Q:GLU49 2.6 101.9 1.0
CA Q:GLY48 2.6 92.4 1.0
O2B Q:GDP401 2.8 99.5 1.0
C Q:GLY48 3.1 92.4 1.0
F3 Q:ALF403 3.6 96.7 1.0
NE2 Q:GLN209 3.8 89.5 1.0
NH2 Q:ARG183 3.8 103.4 1.0
CA Q:GLU49 3.8 101.9 1.0
N Q:GLY208 4.0 88.3 1.0
N Q:GLY48 4.0 92.4 1.0
CA Q:GLY208 4.2 88.3 1.0
PB Q:GDP401 4.2 99.5 1.0
O Q:GLY48 4.3 92.4 1.0
N Q:GLN209 4.4 89.5 1.0
C Q:GLY208 4.5 88.3 1.0
CG Q:GLU49 4.6 101.9 1.0
CG Q:GLN209 4.6 89.5 1.0
NZ Q:LYS52 4.6 94.6 1.0
O Q:THR47 4.6 88.8 1.0
CD Q:GLN209 4.6 89.5 1.0
O2A Q:GDP401 4.7 99.5 1.0
CB Q:GLU49 4.7 101.9 1.0
O3B Q:GDP401 4.7 99.5 1.0
C Q:THR47 4.8 88.8 1.0
O1B Q:GDP401 4.8 99.5 1.0
CZ Q:ARG183 4.9 103.4 1.0
C Q:GLU49 4.9 101.9 1.0
N Q:SER50 5.0 97.6 1.0

Reference:

J.Duan, H.Liu, F.Zhao, Q.Yuan, Y.Ji, X.Cai, X.He, X.Li, J.Li, K.Wu, T.Gao, S.Zhu, S.Lin, M.W.Wang, X.Cheng, W.Yin, Y.Jiang, D.Yang, H.E.Xu. Gpcr Activation and GRK2 Assembly By A Biased Intracellular Agonist. Nature 2023.
ISSN: ESSN 1476-4687
DOI: 10.1038/S41586-023-06395-9
Page generated: Fri Aug 2 20:59:30 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy