Fluorine in PDB 8jvi: Structure of Human TRPV4 with Antagonist A2

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>>> Page 1 <<< Page 2, Binding sites: 11 - 12;

Binding sites:

The binding sites of Fluorine atom in the Structure of Human TRPV4 with Antagonist A2 (pdb code 8jvi). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 12 binding sites of Fluorine where determined in the Structure of Human TRPV4 with Antagonist A2, PDB code: 8jvi:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Fluorine binding site 1 out of 12 in the Structure of Human TRPV4 with Antagonist A2


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Structure of Human TRPV4 with Antagonist A2 within 5.0Å range: probe atom residue distance (Å) B Occ B:F1201 b:40.8 occ:1.00 F03 B:F9M1201 0.0 40.8 1.0 C31 B:F9M1201 1.4 40.8 1.0 F04 B:F9M1201 2.2 40.8 1.0 F05 B:F9M1201 2.2 40.8 1.0 C28 B:F9M1201 2.4 40.8 1.0 C26 B:F9M1201 3.2 40.8 1.0 C27 B:F9M1201 3.4 40.8 1.0 O B:LYS465 3.9 33.8 1.0 CG2 B:VAL469 4.0 42.5 1.0 N09 B:F9M1201 4.5 40.8 1.0 CG1 B:VAL469 4.6 42.5 1.0 O B:ARG464 4.6 32.2 1.0 N10 B:F9M1201 4.6 40.8 1.0 CB B:VAL469 4.8 42.5 1.0 C B:LYS465 4.9 33.8 1.0

Fluorine binding site 2 out of 12 in the Structure of Human TRPV4 with Antagonist A2


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Structure of Human TRPV4 with Antagonist A2 within 5.0Å range: probe atom residue distance (Å) B Occ B:F1201 b:40.8 occ:1.00 F04 B:F9M1201 0.0 40.8 1.0 C31 B:F9M1201 1.4 40.8 1.0 F03 B:F9M1201 2.2 40.8 1.0 F05 B:F9M1201 2.2 40.8 1.0 C28 B:F9M1201 2.4 40.8 1.0 C27 B:F9M1201 2.7 40.8 1.0 C26 B:F9M1201 3.7 40.8 1.0 N10 B:F9M1201 4.2 40.8 1.0 N09 B:F9M1201 4.9 40.8 1.0 O B:LYS465 5.0 33.8 1.0

Fluorine binding site 3 out of 12 in the Structure of Human TRPV4 with Antagonist A2


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Structure of Human TRPV4 with Antagonist A2 within 5.0Å range: probe atom residue distance (Å) B Occ B:F1201 b:40.8 occ:1.00 F05 B:F9M1201 0.0 40.8 1.0 C31 B:F9M1201 1.4 40.8 1.0 F04 B:F9M1201 2.2 40.8 1.0 F03 B:F9M1201 2.2 40.8 1.0 C28 B:F9M1201 2.4 40.8 1.0 C26 B:F9M1201 2.9 40.8 1.0 C27 B:F9M1201 3.6 40.8 1.0 N09 B:F9M1201 4.3 40.8 1.0 N10 B:F9M1201 4.8 40.8 1.0 CG1 B:VAL469 4.9 42.5 1.0

Fluorine binding site 4 out of 12 in the Structure of Human TRPV4 with Antagonist A2


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Structure of Human TRPV4 with Antagonist A2 within 5.0Å range: probe atom residue distance (Å) B Occ C:F1201 b:22.0 occ:1.00 F03 C:F9M1201 0.0 22.0 1.0 C31 C:F9M1201 1.4 22.0 1.0 F05 C:F9M1201 2.2 22.0 1.0 F04 C:F9M1201 2.2 22.0 1.0 C28 C:F9M1201 2.4 22.0 1.0 C26 C:F9M1201 3.2 22.0 1.0 C27 C:F9M1201 3.4 22.0 1.0 N09 C:F9M1201 4.5 22.0 1.0 N10 C:F9M1201 4.6 22.0 1.0

Fluorine binding site 5 out of 12 in the Structure of Human TRPV4 with Antagonist A2


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Structure of Human TRPV4 with Antagonist A2 within 5.0Å range: probe atom residue distance (Å) B Occ C:F1201 b:22.0 occ:1.00 F04 C:F9M1201 0.0 22.0 1.0 C31 C:F9M1201 1.4 22.0 1.0 F05 C:F9M1201 2.2 22.0 1.0 F03 C:F9M1201 2.2 22.0 1.0 C28 C:F9M1201 2.4 22.0 1.0 C26 C:F9M1201 2.9 22.0 1.0 C27 C:F9M1201 3.6 22.0 1.0 CG2 C:VAL469 3.9 21.2 1.0 O C:LYS465 4.1 20.9 1.0 N09 C:F9M1201 4.3 22.0 1.0 O C:ARG464 4.7 20.3 1.0 CB C:VAL469 4.7 21.2 1.0 N10 C:F9M1201 4.8 22.0 1.0 CG1 C:VAL469 5.0 21.2 1.0

Fluorine binding site 6 out of 12 in the Structure of Human TRPV4 with Antagonist A2


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Structure of Human TRPV4 with Antagonist A2 within 5.0Å range: probe atom residue distance (Å) B Occ C:F1201 b:22.0 occ:1.00 F05 C:F9M1201 0.0 22.0 1.0 C31 C:F9M1201 1.4 22.0 1.0 F04 C:F9M1201 2.2 22.0 1.0 F03 C:F9M1201 2.2 22.0 1.0 C28 C:F9M1201 2.4 22.0 1.0 C27 C:F9M1201 2.7 22.0 1.0 C26 C:F9M1201 3.7 22.0 1.0 O C:LYS465 4.1 20.9 1.0 N10 C:F9M1201 4.2 22.0 1.0 N09 C:F9M1201 4.9 22.0 1.0

Fluorine binding site 7 out of 12 in the Structure of Human TRPV4 with Antagonist A2


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 7 of Structure of Human TRPV4 with Antagonist A2 within 5.0Å range: probe atom residue distance (Å) B Occ D:F1201 b:40.8 occ:1.00 F03 D:F9M1201 0.0 40.8 1.0 C31 D:F9M1201 1.4 40.8 1.0 F04 D:F9M1201 2.2 40.8 1.0 F05 D:F9M1201 2.2 40.8 1.0 C28 D:F9M1201 2.4 40.8 1.0 C26 D:F9M1201 3.2 40.8 1.0 C27 D:F9M1201 3.4 40.8 1.0 O D:LYS465 3.9 33.8 1.0 CG2 D:VAL469 4.0 42.5 1.0 N09 D:F9M1201 4.5 40.8 1.0 CG1 D:VAL469 4.6 42.5 1.0 O D:ARG464 4.6 32.2 1.0 N10 D:F9M1201 4.6 40.8 1.0 CB D:VAL469 4.8 42.5 1.0 C D:LYS465 4.9 33.8 1.0

Fluorine binding site 8 out of 12 in the Structure of Human TRPV4 with Antagonist A2


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 8 of Structure of Human TRPV4 with Antagonist A2 within 5.0Å range: probe atom residue distance (Å) B Occ D:F1201 b:40.8 occ:1.00 F04 D:F9M1201 0.0 40.8 1.0 C31 D:F9M1201 1.4 40.8 1.0 F03 D:F9M1201 2.2 40.8 1.0 F05 D:F9M1201 2.2 40.8 1.0 C28 D:F9M1201 2.4 40.8 1.0 C27 D:F9M1201 2.7 40.8 1.0 C26 D:F9M1201 3.7 40.8 1.0 N10 D:F9M1201 4.2 40.8 1.0 N09 D:F9M1201 4.9 40.8 1.0 O D:LYS465 5.0 33.8 1.0

Fluorine binding site 9 out of 12 in the Structure of Human TRPV4 with Antagonist A2


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 9 of Structure of Human TRPV4 with Antagonist A2 within 5.0Å range: probe atom residue distance (Å) B Occ D:F1201 b:40.8 occ:1.00 F05 D:F9M1201 0.0 40.8 1.0 C31 D:F9M1201 1.4 40.8 1.0 F04 D:F9M1201 2.2 40.8 1.0 F03 D:F9M1201 2.2 40.8 1.0 C28 D:F9M1201 2.4 40.8 1.0 C26 D:F9M1201 2.9 40.8 1.0 C27 D:F9M1201 3.6 40.8 1.0 N09 D:F9M1201 4.3 40.8 1.0 N10 D:F9M1201 4.8 40.8 1.0 CG1 D:VAL469 4.9 42.5 1.0

Fluorine binding site 10 out of 12 in the Structure of Human TRPV4 with Antagonist A2


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 10 of Structure of Human TRPV4 with Antagonist A2 within 5.0Å range: probe atom residue distance (Å) B Occ A:F1201 b:22.0 occ:1.00 F03 A:F9M1201 0.0 22.0 1.0 C31 A:F9M1201 1.4 22.0 1.0 F05 A:F9M1201 2.2 22.0 1.0 F04 A:F9M1201 2.2 22.0 1.0 C28 A:F9M1201 2.4 22.0 1.0 C26 A:F9M1201 3.2 22.0 1.0 C27 A:F9M1201 3.4 22.0 1.0 N09 A:F9M1201 4.5 22.0 1.0 N10 A:F9M1201 4.6 22.0 1.0

J.Fan, C.Guo, D.Liao, H.Ke, J.Lei, W.Xie, Y.Tang, M.Tominaga, Z.Huang, X.Lei. Structural Pharmacology of TRPV4 Antagonists. Adv Sci 01583 2024.
ISSN: ESSN 2198-3844
PubMed: 38659239
DOI: 10.1002/ADVS.202401583