Fluorine in PDB 8jvj: Structure of Human TRPV4 with Antagonist A2 and Rhoa
Enzymatic activity of Structure of Human TRPV4 with Antagonist A2 and Rhoa
All present enzymatic activity of Structure of Human TRPV4 with Antagonist A2 and Rhoa:
3.6.5.2;
Fluorine Binding Sites:
Pages:
>>> Page 1 <<<
Page 2, Binding sites: 11 -
12;
Binding sites:
The binding sites of Fluorine atom in the Structure of Human TRPV4 with Antagonist A2 and Rhoa
(pdb code 8jvj). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 12 binding sites of Fluorine where determined in the
Structure of Human TRPV4 with Antagonist A2 and Rhoa, PDB code: 8jvj:
Jump to Fluorine binding site number:
1;
2;
3;
4;
5;
6;
7;
8;
9;
10;
Fluorine binding site 1 out
of 12 in 8jvj
Go back to
Fluorine Binding Sites List in 8jvj
Fluorine binding site 1 out
of 12 in the Structure of Human TRPV4 with Antagonist A2 and Rhoa
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Structure of Human TRPV4 with Antagonist A2 and Rhoa within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F1201
b:75.4
occ:1.00
|
F03
|
A:F9M1201
|
0.0
|
75.4
|
1.0
|
C31
|
A:F9M1201
|
1.4
|
75.4
|
1.0
|
F05
|
A:F9M1201
|
2.2
|
75.4
|
1.0
|
F04
|
A:F9M1201
|
2.2
|
75.4
|
1.0
|
C28
|
A:F9M1201
|
2.3
|
75.4
|
1.0
|
C27
|
A:F9M1201
|
3.1
|
75.4
|
1.0
|
C26
|
A:F9M1201
|
3.4
|
75.4
|
1.0
|
O
|
A:LYS465
|
4.4
|
69.4
|
1.0
|
N10
|
A:F9M1201
|
4.4
|
75.4
|
1.0
|
N09
|
A:F9M1201
|
4.6
|
75.4
|
1.0
|
CG2
|
A:VAL469
|
4.9
|
73.7
|
1.0
|
|
Fluorine binding site 2 out
of 12 in 8jvj
Go back to
Fluorine Binding Sites List in 8jvj
Fluorine binding site 2 out
of 12 in the Structure of Human TRPV4 with Antagonist A2 and Rhoa
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Structure of Human TRPV4 with Antagonist A2 and Rhoa within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F1201
b:75.4
occ:1.00
|
F04
|
A:F9M1201
|
0.0
|
75.4
|
1.0
|
C31
|
A:F9M1201
|
1.4
|
75.4
|
1.0
|
F05
|
A:F9M1201
|
2.2
|
75.4
|
1.0
|
F03
|
A:F9M1201
|
2.2
|
75.4
|
1.0
|
C28
|
A:F9M1201
|
2.4
|
75.4
|
1.0
|
C26
|
A:F9M1201
|
2.7
|
75.4
|
1.0
|
O
|
A:LYS465
|
3.5
|
69.4
|
1.0
|
C27
|
A:F9M1201
|
3.7
|
75.4
|
1.0
|
N09
|
A:F9M1201
|
4.2
|
75.4
|
1.0
|
CE2
|
A:PHE756
|
4.6
|
88.5
|
1.0
|
C
|
A:LYS465
|
4.6
|
69.4
|
1.0
|
N10
|
A:F9M1201
|
4.9
|
75.4
|
1.0
|
|
Fluorine binding site 3 out
of 12 in 8jvj
Go back to
Fluorine Binding Sites List in 8jvj
Fluorine binding site 3 out
of 12 in the Structure of Human TRPV4 with Antagonist A2 and Rhoa
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Structure of Human TRPV4 with Antagonist A2 and Rhoa within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F1201
b:75.4
occ:1.00
|
F05
|
A:F9M1201
|
0.0
|
75.4
|
1.0
|
C31
|
A:F9M1201
|
1.4
|
75.4
|
1.0
|
F04
|
A:F9M1201
|
2.2
|
75.4
|
1.0
|
F03
|
A:F9M1201
|
2.2
|
75.4
|
1.0
|
C28
|
A:F9M1201
|
2.4
|
75.4
|
1.0
|
O
|
A:LYS465
|
2.4
|
69.4
|
1.0
|
C27
|
A:F9M1201
|
2.9
|
75.4
|
1.0
|
O
|
A:ARG464
|
3.3
|
68.0
|
1.0
|
C
|
A:LYS465
|
3.3
|
69.4
|
1.0
|
C26
|
A:F9M1201
|
3.6
|
75.4
|
1.0
|
CA
|
A:LYS465
|
3.8
|
69.4
|
1.0
|
N10
|
A:F9M1201
|
4.3
|
75.4
|
1.0
|
C
|
A:ARG464
|
4.3
|
68.0
|
1.0
|
N
|
A:PHE466
|
4.4
|
71.6
|
1.0
|
N
|
A:LYS465
|
4.6
|
69.4
|
1.0
|
CG2
|
A:VAL469
|
4.7
|
73.7
|
1.0
|
CA
|
A:PHE466
|
4.7
|
71.6
|
1.0
|
N09
|
A:F9M1201
|
4.8
|
75.4
|
1.0
|
|
Fluorine binding site 4 out
of 12 in 8jvj
Go back to
Fluorine Binding Sites List in 8jvj
Fluorine binding site 4 out
of 12 in the Structure of Human TRPV4 with Antagonist A2 and Rhoa
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Structure of Human TRPV4 with Antagonist A2 and Rhoa within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:F1201
b:73.1
occ:1.00
|
F03
|
B:F9M1201
|
0.0
|
73.1
|
1.0
|
C31
|
B:F9M1201
|
1.4
|
73.1
|
1.0
|
F05
|
B:F9M1201
|
2.2
|
73.1
|
1.0
|
F04
|
B:F9M1201
|
2.2
|
73.1
|
1.0
|
C28
|
B:F9M1201
|
2.4
|
73.1
|
1.0
|
C27
|
B:F9M1201
|
3.0
|
73.1
|
1.0
|
C26
|
B:F9M1201
|
3.5
|
73.1
|
1.0
|
O
|
B:LYS465
|
4.3
|
66.3
|
1.0
|
N10
|
B:F9M1201
|
4.4
|
73.1
|
1.0
|
N09
|
B:F9M1201
|
4.7
|
73.1
|
1.0
|
|
Fluorine binding site 5 out
of 12 in 8jvj
Go back to
Fluorine Binding Sites List in 8jvj
Fluorine binding site 5 out
of 12 in the Structure of Human TRPV4 with Antagonist A2 and Rhoa
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 5 of Structure of Human TRPV4 with Antagonist A2 and Rhoa within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:F1201
b:73.1
occ:1.00
|
F04
|
B:F9M1201
|
0.0
|
73.1
|
1.0
|
C31
|
B:F9M1201
|
1.4
|
73.1
|
1.0
|
F05
|
B:F9M1201
|
2.2
|
73.1
|
1.0
|
F03
|
B:F9M1201
|
2.2
|
73.1
|
1.0
|
C28
|
B:F9M1201
|
2.4
|
73.1
|
1.0
|
C26
|
B:F9M1201
|
2.7
|
73.1
|
1.0
|
C27
|
B:F9M1201
|
3.7
|
73.1
|
1.0
|
N09
|
B:F9M1201
|
4.2
|
73.1
|
1.0
|
CG1
|
B:VAL469
|
4.7
|
73.2
|
1.0
|
O
|
B:LYS465
|
4.9
|
66.3
|
1.0
|
N10
|
B:F9M1201
|
4.9
|
73.1
|
1.0
|
|
Fluorine binding site 6 out
of 12 in 8jvj
Go back to
Fluorine Binding Sites List in 8jvj
Fluorine binding site 6 out
of 12 in the Structure of Human TRPV4 with Antagonist A2 and Rhoa
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 6 of Structure of Human TRPV4 with Antagonist A2 and Rhoa within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:F1201
b:73.1
occ:1.00
|
F05
|
B:F9M1201
|
0.0
|
73.1
|
1.0
|
C31
|
B:F9M1201
|
1.4
|
73.1
|
1.0
|
F03
|
B:F9M1201
|
2.2
|
73.1
|
1.0
|
F04
|
B:F9M1201
|
2.2
|
73.1
|
1.0
|
C28
|
B:F9M1201
|
2.4
|
73.1
|
1.0
|
O
|
B:LYS465
|
2.8
|
66.3
|
1.0
|
C27
|
B:F9M1201
|
3.0
|
73.1
|
1.0
|
C26
|
B:F9M1201
|
3.6
|
73.1
|
1.0
|
O
|
B:ARG464
|
3.8
|
66.3
|
1.0
|
C
|
B:LYS465
|
3.9
|
66.3
|
1.0
|
N10
|
B:F9M1201
|
4.3
|
73.1
|
1.0
|
CA
|
B:LYS465
|
4.4
|
66.3
|
1.0
|
N09
|
B:F9M1201
|
4.8
|
73.1
|
1.0
|
CG1
|
B:VAL469
|
4.8
|
73.2
|
1.0
|
C
|
B:ARG464
|
4.9
|
66.3
|
1.0
|
N
|
B:PHE466
|
5.0
|
69.9
|
1.0
|
|
Fluorine binding site 7 out
of 12 in 8jvj
Go back to
Fluorine Binding Sites List in 8jvj
Fluorine binding site 7 out
of 12 in the Structure of Human TRPV4 with Antagonist A2 and Rhoa
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 7 of Structure of Human TRPV4 with Antagonist A2 and Rhoa within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:F1201
b:75.3
occ:1.00
|
F03
|
C:F9M1201
|
0.0
|
75.3
|
1.0
|
C31
|
C:F9M1201
|
1.4
|
75.3
|
1.0
|
F05
|
C:F9M1201
|
2.2
|
75.3
|
1.0
|
F04
|
C:F9M1201
|
2.2
|
75.3
|
1.0
|
C28
|
C:F9M1201
|
2.4
|
75.3
|
1.0
|
C26
|
C:F9M1201
|
3.3
|
75.3
|
1.0
|
C27
|
C:F9M1201
|
3.3
|
75.3
|
1.0
|
O
|
C:LYS465
|
4.5
|
66.3
|
1.0
|
N10
|
C:F9M1201
|
4.6
|
75.3
|
1.0
|
N09
|
C:F9M1201
|
4.6
|
75.3
|
1.0
|
|
Fluorine binding site 8 out
of 12 in 8jvj
Go back to
Fluorine Binding Sites List in 8jvj
Fluorine binding site 8 out
of 12 in the Structure of Human TRPV4 with Antagonist A2 and Rhoa
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 8 of Structure of Human TRPV4 with Antagonist A2 and Rhoa within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:F1201
b:75.3
occ:1.00
|
F04
|
C:F9M1201
|
0.0
|
75.3
|
1.0
|
C31
|
C:F9M1201
|
1.4
|
75.3
|
1.0
|
F05
|
C:F9M1201
|
2.2
|
75.3
|
1.0
|
F03
|
C:F9M1201
|
2.2
|
75.3
|
1.0
|
C28
|
C:F9M1201
|
2.4
|
75.3
|
1.0
|
O
|
C:LYS465
|
2.6
|
66.3
|
1.0
|
C26
|
C:F9M1201
|
2.8
|
75.3
|
1.0
|
O
|
C:ARG464
|
3.2
|
64.8
|
1.0
|
C
|
C:LYS465
|
3.5
|
66.3
|
1.0
|
C27
|
C:F9M1201
|
3.7
|
75.3
|
1.0
|
CA
|
C:LYS465
|
4.0
|
66.3
|
1.0
|
N09
|
C:F9M1201
|
4.2
|
75.3
|
1.0
|
C
|
C:ARG464
|
4.3
|
64.8
|
1.0
|
N
|
C:PHE466
|
4.6
|
70.6
|
1.0
|
N
|
C:LYS465
|
4.6
|
66.3
|
1.0
|
CG1
|
C:VAL469
|
4.7
|
74.3
|
1.0
|
N10
|
C:F9M1201
|
4.8
|
75.3
|
1.0
|
CA
|
C:PHE466
|
4.9
|
70.6
|
1.0
|
|
Fluorine binding site 9 out
of 12 in 8jvj
Go back to
Fluorine Binding Sites List in 8jvj
Fluorine binding site 9 out
of 12 in the Structure of Human TRPV4 with Antagonist A2 and Rhoa
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 9 of Structure of Human TRPV4 with Antagonist A2 and Rhoa within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:F1201
b:75.3
occ:1.00
|
F05
|
C:F9M1201
|
0.0
|
75.3
|
1.0
|
C31
|
C:F9M1201
|
1.4
|
75.3
|
1.0
|
F04
|
C:F9M1201
|
2.2
|
75.3
|
1.0
|
F03
|
C:F9M1201
|
2.2
|
75.3
|
1.0
|
C28
|
C:F9M1201
|
2.4
|
75.3
|
1.0
|
C27
|
C:F9M1201
|
2.8
|
75.3
|
1.0
|
O
|
C:LYS465
|
3.5
|
66.3
|
1.0
|
C26
|
C:F9M1201
|
3.7
|
75.3
|
1.0
|
N10
|
C:F9M1201
|
4.2
|
75.3
|
1.0
|
C
|
C:LYS465
|
4.6
|
66.3
|
1.0
|
N09
|
C:F9M1201
|
4.9
|
75.3
|
1.0
|
|
Fluorine binding site 10 out
of 12 in 8jvj
Go back to
Fluorine Binding Sites List in 8jvj
Fluorine binding site 10 out
of 12 in the Structure of Human TRPV4 with Antagonist A2 and Rhoa
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 10 of Structure of Human TRPV4 with Antagonist A2 and Rhoa within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:F1201
b:74.7
occ:1.00
|
F03
|
D:F9M1201
|
0.0
|
74.7
|
1.0
|
C31
|
D:F9M1201
|
1.4
|
74.7
|
1.0
|
F05
|
D:F9M1201
|
2.2
|
74.7
|
1.0
|
F04
|
D:F9M1201
|
2.2
|
74.7
|
1.0
|
C28
|
D:F9M1201
|
2.4
|
74.7
|
1.0
|
C27
|
D:F9M1201
|
3.3
|
74.7
|
1.0
|
C26
|
D:F9M1201
|
3.3
|
74.7
|
1.0
|
O
|
D:LYS465
|
4.5
|
66.8
|
1.0
|
N10
|
D:F9M1201
|
4.6
|
74.7
|
1.0
|
N09
|
D:F9M1201
|
4.6
|
74.7
|
1.0
|
CG1
|
D:VAL469
|
4.9
|
74.6
|
1.0
|
|
Reference:
J.Fan,
C.Guo,
D.Liao,
H.Ke,
J.Lei,
W.Xie,
Y.Tang,
M.Tominaga,
Z.Huang,
X.Lei.
Structural Pharmacology of TRPV4 Antagonists. Adv Sci 01583 2024.
ISSN: ESSN 2198-3844
PubMed: 38659239
DOI: 10.1002/ADVS.202401583
Page generated: Fri Aug 2 21:03:43 2024
|