Fluorine in PDB 8kct: Cryo-Em Structure of Human Gamma-Secretase in Complex with Nirogacestat

The binding sites of Fluorine atom in the Cryo-Em Structure of Human Gamma-Secretase in Complex with Nirogacestat (pdb code 8kct). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Cryo-Em Structure of Human Gamma-Secretase in Complex with Nirogacestat, PDB code: 8kct:
Jump to Fluorine binding site number: 1; 2;

Fluorine binding site 1 out of 2 in the Cryo-Em Structure of Human Gamma-Secretase in Complex with Nirogacestat


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of Human Gamma-Secretase in Complex with Nirogacestat within 5.0Å range: probe atom residue distance (Å) B Occ B:F502 b:109.1 occ:1.00 F01 B:O6U502 0.0 109.1 1.0 C23 B:O6U502 1.4 109.1 1.0 C13 B:O6U502 2.5 109.1 1.0 C33 B:O6U502 2.5 109.1 1.0 C11 B:O6U502 3.2 109.1 1.0 CG2 B:ILE287 3.2 106.1 1.0 CB B:ILE287 3.9 106.1 1.0 C16 B:O6U502 3.9 109.1 1.0 C34 B:O6U502 3.9 109.1 1.0 CB B:LYS380 4.2 104.9 1.0 C29 B:O6U502 4.3 109.1 1.0 N B:GLY382 4.3 101.7 1.0 C B:LEU381 4.3 101.7 1.0 N B:LEU381 4.4 101.7 1.0 C09 B:O6U502 4.4 109.1 1.0 C25 B:O6U502 4.5 109.1 1.0 C B:LYS380 4.5 104.9 1.0 CA B:LEU381 4.6 101.7 1.0 O B:LEU381 4.7 101.7 1.0 O B:LYS380 4.7 104.9 1.0 CA B:GLY382 4.7 101.7 1.0 CA B:ILE287 4.9 106.1 1.0 CD1 B:ILE287 4.9 106.1 1.0 CG1 B:ILE287 5.0 106.1 1.0

Fluorine binding site 2 out of 2 in the Cryo-Em Structure of Human Gamma-Secretase in Complex with Nirogacestat


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Cryo-Em Structure of Human Gamma-Secretase in Complex with Nirogacestat within 5.0Å range: probe atom residue distance (Å) B Occ B:F502 b:109.1 occ:1.00 F02 B:O6U502 0.0 109.1 1.0 C34 B:O6U502 1.4 109.1 1.0 C25 B:O6U502 2.5 109.1 1.0 C33 B:O6U502 2.5 109.1 1.0 CD1 B:LEU282 3.2 128.6 1.0 CD2 B:LEU271 3.3 131.3 1.0 C16 B:O6U502 3.9 109.1 1.0 C23 B:O6U502 3.9 109.1 1.0 CG2 B:VAL272 4.4 131.7 1.0 C13 B:O6U502 4.4 109.1 1.0 CG B:LEU268 4.6 126.9 1.0 CG B:LEU271 4.6 131.3 1.0 CG B:LEU282 4.7 128.6 1.0 O B:LEU268 4.8 126.9 1.0 CB B:LEU271 5.0 131.3 1.0

X.Guo, H.Li, U.Kai, C.Yan, J.Lei, R.Zhou, Y.Shi. Structural Basis of Gamma-Secretase Inhibition By Anti-Cancer Clinical Drugs To Be Published.