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Fluorine in PDB 8our: Crystal Structure of Dlk in Complex with Compound 16Enzymatic activity of Crystal Structure of Dlk in Complex with Compound 16
All present enzymatic activity of Crystal Structure of Dlk in Complex with Compound 16:
2.7.11.25; Protein crystallography data
The structure of Crystal Structure of Dlk in Complex with Compound 16, PDB code: 8our
was solved by
M.Zebisch,
P.A.Mcewan,
J.J.Barker,
J.B.Cross,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Dlk in Complex with Compound 16
(pdb code 8our). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Crystal Structure of Dlk in Complex with Compound 16, PDB code: 8our: Jump to Fluorine binding site number: 1; 2; 3; Fluorine binding site 1 out of 3 in 8ourGo back to Fluorine Binding Sites List in 8our
Fluorine binding site 1 out
of 3 in the Crystal Structure of Dlk in Complex with Compound 16
Mono view Stereo pair view
Fluorine binding site 2 out of 3 in 8ourGo back to Fluorine Binding Sites List in 8our
Fluorine binding site 2 out
of 3 in the Crystal Structure of Dlk in Complex with Compound 16
Mono view Stereo pair view
Fluorine binding site 3 out of 3 in 8ourGo back to Fluorine Binding Sites List in 8our
Fluorine binding site 3 out
of 3 in the Crystal Structure of Dlk in Complex with Compound 16
Mono view Stereo pair view
Reference:
K.Le,
M.J.Soth,
J.B.Cross,
G.Liu,
W.J.Ray,
J.Ma,
S.G.Goodwani,
P.J.Acton,
V.Buggia-Prevot,
O.Akkermans,
J.Barker,
M.L.Conner,
Y.Jiang,
Z.Liu,
P.Mcewan,
J.Warner-Schmidt,
A.Xu,
M.Zebisch,
C.J.Heijnen,
B.Abrahams,
P.Jones.
Discovery of Iacs-52825, A Potent and Selective Dlk Inhibitor For Treatment of Chemotherapy-Induced Peripheral Neuropathy. J.Med.Chem. 2023.
Page generated: Fri Aug 2 21:15:22 2024
ISSN: ISSN 0022-2623 PubMed: 37436942 DOI: 10.1021/ACS.JMEDCHEM.3C00788 |
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