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Fluorine in PDB 8ov7: Crystal Structure of D1228V C-Met Bound By Compound 10Enzymatic activity of Crystal Structure of D1228V C-Met Bound By Compound 10
All present enzymatic activity of Crystal Structure of D1228V C-Met Bound By Compound 10:
2.7.10.1; Protein crystallography data
The structure of Crystal Structure of D1228V C-Met Bound By Compound 10, PDB code: 8ov7
was solved by
G.W.Collie,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of D1228V C-Met Bound By Compound 10
(pdb code 8ov7). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of D1228V C-Met Bound By Compound 10, PDB code: 8ov7: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 8ov7Go back to Fluorine Binding Sites List in 8ov7
Fluorine binding site 1 out
of 2 in the Crystal Structure of D1228V C-Met Bound By Compound 10
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 8ov7Go back to Fluorine Binding Sites List in 8ov7
Fluorine binding site 2 out
of 2 in the Crystal Structure of D1228V C-Met Bound By Compound 10
Mono view Stereo pair view
Reference:
I.N.Michaelides,
G.W.Collie,
U.Borjesson,
C.Vasalou,
O.Alkhatib,
L.Barlind,
T.Cheung,
I.L.Dale,
K.J.Embrey,
E.J.Hennessy,
P.Khurana,
C.M.Koh,
M.L.Lamb,
J.Liu,
T.A.Moss,
D.J.O'neill,
C.Phillips,
J.Shaw,
A.Snijder,
R.I.Storer,
C.J.Stubbs,
F.Han,
C.Li,
J.Qiao,
D.Q.Sun,
J.Wang,
P.Wang,
W.Yang.
Discovery and Optimization of the First Atp Competitive Type-III C-Met Inhibitor. J.Med.Chem. 2023.
Page generated: Fri Aug 2 21:16:45 2024
ISSN: ISSN 0022-2623 PubMed: 37343272 DOI: 10.1021/ACS.JMEDCHEM.3C00401 |
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