Fluorine in PDB 8pbi: Mutant R1617Q of the Dihydroorotase Domain of Human Cad Protein Bound to the Inhibitor Fluoroorotate

Enzymatic activity of Mutant R1617Q of the Dihydroorotase Domain of Human Cad Protein Bound to the Inhibitor Fluoroorotate

All present enzymatic activity of Mutant R1617Q of the Dihydroorotase Domain of Human Cad Protein Bound to the Inhibitor Fluoroorotate:
2.1.3.2; 3.5.2.3; 6.3.5.5;

Protein crystallography data

The structure of Mutant R1617Q of the Dihydroorotase Domain of Human Cad Protein Bound to the Inhibitor Fluoroorotate, PDB code: 8pbi was solved by F.Del Cano-Ochoa, S.Ramon-Maiques, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 41.12 / 1.50
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 82.237, 159.575, 61.844, 90, 90, 90
R / Rfree (%) 13.3 / 15.7

Other elements in 8pbi:

The structure of Mutant R1617Q of the Dihydroorotase Domain of Human Cad Protein Bound to the Inhibitor Fluoroorotate also contains other interesting chemical elements:

Zinc (Zn) 2 atoms

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Mutant R1617Q of the Dihydroorotase Domain of Human Cad Protein Bound to the Inhibitor Fluoroorotate (pdb code 8pbi). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Mutant R1617Q of the Dihydroorotase Domain of Human Cad Protein Bound to the Inhibitor Fluoroorotate, PDB code: 8pbi:

Fluorine binding site 1 out of 1 in 8pbi

Go back to Fluorine Binding Sites List in 8pbi
Fluorine binding site 1 out of 1 in the Mutant R1617Q of the Dihydroorotase Domain of Human Cad Protein Bound to the Inhibitor Fluoroorotate


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Mutant R1617Q of the Dihydroorotase Domain of Human Cad Protein Bound to the Inhibitor Fluoroorotate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F1901

b:22.0
occ:1.00
 F5 A:FOT1901 0.0 22.0 1.0
C5 A:FOT1901 1.3 18.7 1.0
C6 A:FOT1901 2.4 19.4 1.0
C4 A:FOT1901 2.4 19.8 1.0
HD21 A:ASN1505 2.7 23.4 1.0
O6 A:FOT1901 2.8 20.6 1.0
O41 A:FOT1901 2.8 20.9 1.0
HE1 A:TYR1558 2.9 22.2 1.0
HD22 A:ASN1505 3.0 23.4 1.0
C41 A:FOT1901 3.0 20.3 1.0
ND2 A:ASN1505 3.1 19.5 1.0
HE1 A:HIS1473 3.1 21.9 1.0
O A:HOH2081 3.3 45.7 1.0
O A:HOH2060 3.5 32.9 1.0
CE1 A:HIS1473 3.5 18.3 1.0
N1 A:FOT1901 3.6 19.6 1.0
N3 A:FOT1901 3.6 20.3 1.0
CE1 A:TYR1558 3.7 18.5 1.0
O A:HOH2133 3.8 19.5 1.0
OQ1 A:KCX1556 3.8 19.8 1.0
NE2 A:HIS1473 3.9 17.7 1.0
ZN A:ZN1905 4.1 17.4 0.9
C2 A:FOT1901 4.1 20.3 1.0
O42 A:FOT1901 4.2 20.9 1.0
CG A:ASN1505 4.2 19.3 1.0
OH A:TYR1558 4.2 19.4 1.0
HN3 A:FOT1901 4.2 24.3 1.0
HN1 A:FOT1901 4.2 23.5 1.0
ZN A:ZN1906 4.4 17.9 0.8
ND1 A:HIS1473 4.4 17.9 1.0
CZ A:TYR1558 4.4 18.5 1.0
HD1 A:TYR1558 4.5 21.8 1.0
CD1 A:TYR1558 4.6 18.1 1.0
CX A:KCX1556 4.6 19.4 1.0
HD1 A:HIS1473 4.7 21.4 1.0
OQ2 A:KCX1556 4.7 20.0 1.0
HH12 A:ARG1475 4.8 23.0 1.0
OD1 A:ASN1505 4.8 19.9 1.0
CD2 A:HIS1473 4.9 18.0 1.0
HH A:TYR1558 5.0 23.3 1.0

Reference:

F.Del Cano-Ochoa, B.G.Ng, A.Rubio-Del-Campo, S.Mahajan, M.P.Wilson, M.Vilar, D.Rymen, P.Sanchez-Pintos, J.Kenny, M.Ley Martos, T.Campos, S.B.Wortmann, H.H.Freeze, S.Ramon-Maiques. Beyond Genetics: Deciphering the Impact of Missense Variants in Cad Deficiency. J Inherit Metab Dis 2023.
ISSN: ISSN 1573-2665
PubMed: 37540500
DOI: 10.1002/JIMD.12667
Page generated: Fri Aug 2 21:56:54 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy