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Fluorine in PDB 8qow: LTA4 Hydrolase in Complex with Compound 2(S)Enzymatic activity of LTA4 Hydrolase in Complex with Compound 2(S)
All present enzymatic activity of LTA4 Hydrolase in Complex with Compound 2(S):
3.3.2.6; Protein crystallography data
The structure of LTA4 Hydrolase in Complex with Compound 2(S), PDB code: 8qow
was solved by
H.Srinivas,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 8qow:
The structure of LTA4 Hydrolase in Complex with Compound 2(S) also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the LTA4 Hydrolase in Complex with Compound 2(S)
(pdb code 8qow). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the LTA4 Hydrolase in Complex with Compound 2(S), PDB code: 8qow: Fluorine binding site 1 out of 1 in 8qowGo back to Fluorine Binding Sites List in 8qow
Fluorine binding site 1 out
of 1 in the LTA4 Hydrolase in Complex with Compound 2(S)
Mono view Stereo pair view
Reference:
G.Thoma,
C.Markert,
R.Lueoend,
W.Miltz,
C.Spanka,
B.Bollbuck,
R.M.Wolf,
H.Srinivas,
C.A.Penno,
M.Kiffe,
M.Gajewska,
D.Bednarczyk,
G.Wieczorek,
A.Evans,
C.Beerli,
T.A.Rohn.
Discovery of Amino Alcohols As Highly Potent, Selective, and Orally Efficacious Inhibitors of Leukotriene A4 Hydrolase. J.Med.Chem. 2023.
Page generated: Fri Aug 2 22:31:09 2024
ISSN: ISSN 0022-2623 PubMed: 38015154 DOI: 10.1021/ACS.JMEDCHEM.3C01866 |
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