Fluorine in PDB 8qqy: Crystal Structure of Human Ephrin Type-A Receptor 2 (EPHA2) Kinase Domain in Complex with JG165

Enzymatic activity of Crystal Structure of Human Ephrin Type-A Receptor 2 (EPHA2) Kinase Domain in Complex with JG165

All present enzymatic activity of Crystal Structure of Human Ephrin Type-A Receptor 2 (EPHA2) Kinase Domain in Complex with JG165:
2.7.10.1;

Protein crystallography data

The structure of Crystal Structure of Human Ephrin Type-A Receptor 2 (EPHA2) Kinase Domain in Complex with JG165, PDB code: 8qqy was solved by R.Zhubi, J.Gerninghaus, S.Knapp, A.Kraemer, Structural Genomicsconsortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 38.41 / 1.80
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 32.818, 107.676, 40.636, 90, 109.18, 90
R / Rfree (%) 18.9 / 22.3

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Crystal Structure of Human Ephrin Type-A Receptor 2 (EPHA2) Kinase Domain in Complex with JG165 (pdb code 8qqy). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of Human Ephrin Type-A Receptor 2 (EPHA2) Kinase Domain in Complex with JG165, PDB code: 8qqy:

Fluorine binding site 1 out of 1 in 8qqy

Go back to Fluorine Binding Sites List in 8qqy
Fluorine binding site 1 out of 1 in the Crystal Structure of Human Ephrin Type-A Receptor 2 (EPHA2) Kinase Domain in Complex with JG165


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Crystal Structure of Human Ephrin Type-A Receptor 2 (EPHA2) Kinase Domain in Complex with JG165 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F1001

b:22.6
occ:1.00
 F A:WT31001 0.0 22.6 1.0
C19 A:WT31001 1.4 20.9 1.0
C1 A:WT31001 2.4 20.3 1.0
C18 A:WT31001 2.4 20.7 1.0
O A:WT31001 2.6 19.9 1.0
O A:HOH1125 3.2 29.9 1.0
NZ A:LYS646 3.2 37.6 1.0
CE A:MET667 3.6 33.0 1.0
CE A:LYS646 3.6 33.8 1.0
C2 A:WT31001 3.6 18.9 1.0
C17 A:WT31001 3.6 20.7 1.0
O A:HOH1159 3.7 45.2 1.0
OE2 A:GLU663 3.7 26.0 1.0
SD A:MET667 3.7 33.1 1.0
CG2 A:THR692 3.9 17.1 1.0
C A:WT31001 4.0 20.7 1.0
C3 A:WT31001 4.1 18.8 1.0
CG2 A:ILE690 4.3 16.6 1.0
O A:SER756 4.5 28.7 1.0
O A:HOH1231 4.6 15.4 1.0
CD A:LYS646 4.7 31.4 1.0
CD A:GLU663 4.8 27.8 1.0
OG1 A:THR692 5.0 14.5 1.0

Reference:

R.Zhubi, J.Gerninghaus, S.Knapp, A.Kraemer, Structural Genomics Consortium (Sgc). Crystal Structure of Human Ephrin Type-A Receptor 2 (EPHA2) Kinase Domain in Complex with JG165 To Be Published.
Page generated: Fri Aug 2 22:31:08 2024

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