Fluorine in PDB 8rq8: Crystal Structure of Crbn-Midi in Complex with Mezigdomide

The structure of Crystal Structure of Crbn-Midi in Complex with Mezigdomide, PDB code: 8rq8 was solved by D.Zollman, A.Kroupova, J.Pethe, A.Ciulli, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	40.59 / 2.19
Space group	P 43 21 2
Cell size a, b, c (Å), α, β, γ (°)	51.046, 51.046, 267.677, 90, 90, 90
R / Rfree (%)	25.8 / 28.5

The structure of Crystal Structure of Crbn-Midi in Complex with Mezigdomide also contains other interesting chemical elements:

Zinc

(Zn)

1 atom

The binding sites of Fluorine atom in the Crystal Structure of Crbn-Midi in Complex with Mezigdomide (pdb code 8rq8). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of Crbn-Midi in Complex with Mezigdomide, PDB code: 8rq8:

Fluorine binding site 1 out of 1 in the Crystal Structure of Crbn-Midi in Complex with Mezigdomide


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Crystal Structure of Crbn-Midi in Complex with Mezigdomide within 5.0Å range: probe atom residue distance (Å) B Occ A:F601 b:29.0 occ:1.00 F A:QFC601 0.0 29.0 1.0 C A:QFC601 1.3 32.3 1.0 C5 A:QFC601 2.4 27.4 1.0 C1 A:QFC601 2.4 32.4 1.0 N A:QFC601 2.8 25.0 1.0 C30 A:QFC601 3.0 27.2 1.0 OD2 A:ASP149 3.5 42.3 1.0 C4 A:QFC601 3.7 30.7 1.0 C2 A:QFC601 3.7 36.5 1.0 C29 A:QFC601 4.0 28.9 1.0 C3 A:QFC601 4.2 37.3 1.0 CG A:ASP149 4.2 51.6 1.0 C6 A:QFC601 4.3 26.3 1.0 OD1 A:ASP149 4.9 58.9 1.0 CB A:ASP149 4.9 48.3 1.0 C31 A:QFC601 5.0 33.9 1.0

A.Kroupova, D.Zollman, A.Ciulli. Design of A Cereblon Construct For Crystallographic and Biophysical Studies of Protein Degraders To Be Published.