Fluorine in PDB 8t4o: Human Mitochondrial Serine Hydroxymethyltransferase (SHMT2) in Complex with Plp, Glycine and AGF347 Inhibitor with No Glutamate

Enzymatic activity of Human Mitochondrial Serine Hydroxymethyltransferase (SHMT2) in Complex with Plp, Glycine and AGF347 Inhibitor with No Glutamate

All present enzymatic activity of Human Mitochondrial Serine Hydroxymethyltransferase (SHMT2) in Complex with Plp, Glycine and AGF347 Inhibitor with No Glutamate:
2.1.2.1;

Protein crystallography data

The structure of Human Mitochondrial Serine Hydroxymethyltransferase (SHMT2) in Complex with Plp, Glycine and AGF347 Inhibitor with No Glutamate, PDB code: 8t4o was solved by J.M.Katinas, C.E.Dann Iii, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 48.78 / 2.68
Space group P 65 2 2
Cell size a, b, c (Å), α, β, γ (°) 158.538, 158.538, 208.009, 90, 90, 120
R / Rfree (%) 21.5 / 25.9

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Human Mitochondrial Serine Hydroxymethyltransferase (SHMT2) in Complex with Plp, Glycine and AGF347 Inhibitor with No Glutamate (pdb code 8t4o). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Human Mitochondrial Serine Hydroxymethyltransferase (SHMT2) in Complex with Plp, Glycine and AGF347 Inhibitor with No Glutamate, PDB code: 8t4o:

Fluorine binding site 1 out of 1 in 8t4o

Go back to Fluorine Binding Sites List in 8t4o
Fluorine binding site 1 out of 1 in the Human Mitochondrial Serine Hydroxymethyltransferase (SHMT2) in Complex with Plp, Glycine and AGF347 Inhibitor with No Glutamate


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Human Mitochondrial Serine Hydroxymethyltransferase (SHMT2) in Complex with Plp, Glycine and AGF347 Inhibitor with No Glutamate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F601

b:75.0
occ:1.00
 F25 A:Y5C601 0.0 75.0 1.0
C13 A:Y5C601 1.4 69.8 1.0
C12 A:Y5C601 2.4 67.7 1.0
C15 A:Y5C601 2.4 66.8 1.0
O18 A:Y5C601 2.5 74.3 1.0
C17 A:Y5C601 2.8 78.7 1.0
CD1 A:ILE183 3.6 41.3 1.0
C14 A:Y5C601 3.6 58.7 1.0
C24 A:Y5C601 3.7 60.3 1.0
OH B:TYR105 3.9 80.3 1.0
CG2 A:ILE183 4.0 26.4 1.0
C16 A:Y5C601 4.1 59.6 1.0
O19 A:Y5C601 4.3 84.5 1.0
CG1 A:ILE183 4.3 28.1 1.0
CG B:PRO321 4.4 37.5 1.0
CE2 A:TYR176 4.6 42.2 1.0
CB A:ILE183 4.7 27.4 1.0
CZ B:TYR105 4.8 86.8 1.0
C23 A:Y5C601 4.9 62.1 1.0

Reference:

J.M.Katinas, M.J.Nayeen, M.Schneider, K.Shah, A.N.Fifer, L.M.Klapper, A.Sharma, K.Thalluri, M.S.Van Nieuwenhze, Z.Hou, A.Gangjee, L.H.Matherly, C.E.Dann 3Rd. Structural Characterization of 5-Substituted Pyrrolo[3,2- D ]Pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2. Biochemistry 2024.
ISSN: ISSN 0006-2960
PubMed: 38324671
DOI: 10.1021/ACS.BIOCHEM.3C00613
Page generated: Sat Aug 3 00:23:02 2024

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