Fluorine in PDB 8uq7: Alzheimer'S Disease Phf Complexed with Pet Ligand Mk-6240

The binding sites of Fluorine atom in the Alzheimer'S Disease Phf Complexed with Pet Ligand Mk-6240 (pdb code 8uq7). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Alzheimer'S Disease Phf Complexed with Pet Ligand Mk-6240, PDB code: 8uq7:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;

Fluorine binding site 1 out of 6 in the Alzheimer'S Disease Phf Complexed with Pet Ligand Mk-6240


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Alzheimer'S Disease Phf Complexed with Pet Ligand Mk-6240 within 5.0Å range: probe atom residue distance (Å) B Occ A:F401 b:0.0 occ:1.00 F A:X6R401 0.0 0.0 1.0 C2 A:X6R401 1.4 0.0 1.0 C1 A:X6R401 2.4 0.0 1.0 C3 A:X6R401 2.4 0.0 1.0 H2 A:X6R401 2.4 0.0 1.0 H3 A:X6R401 2.6 0.0 1.0 N1 A:X6R401 2.8 0.0 1.0 HE21 F:GLN351 2.8 100.0 1.0 HG2 F:GLN351 3.1 100.0 1.0 HB3 F:GLN351 3.2 100.0 1.0 NE2 F:GLN351 3.2 100.0 1.0 CD F:GLN351 3.6 100.0 1.0 C4 A:X6R401 3.6 0.0 1.0 C16 A:X6R401 3.6 0.0 1.0 CG F:GLN351 3.7 100.0 1.0 H1 A:X6R401 3.7 0.0 1.0 HE22 F:GLN351 3.8 100.0 1.0 CB F:GLN351 3.9 100.0 1.0 C5 A:X6R401 4.1 0.0 1.0 HA F:GLN351 4.2 100.0 1.0 OE1 F:GLN351 4.5 100.0 1.0 H4 A:X6R401 4.5 0.0 1.0 CA F:GLN351 4.7 100.0 1.0 HG3 F:GLN351 4.7 100.0 1.0 HB2 F:GLN351 4.8 100.0 1.0 F B:X6R401 4.8 0.0 1.0 C15 A:X6R401 4.8 0.0 1.0 H11 A:X6R401 5.0 0.0 1.0

Fluorine binding site 2 out of 6 in the Alzheimer'S Disease Phf Complexed with Pet Ligand Mk-6240


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Alzheimer'S Disease Phf Complexed with Pet Ligand Mk-6240 within 5.0Å range: probe atom residue distance (Å) B Occ A:F402 b:0.0 occ:1.00 F A:X6R402 0.0 0.0 1.0 C2 A:X6R402 1.4 0.0 1.0 C1 A:X6R402 2.4 0.0 1.0 C3 A:X6R402 2.4 0.0 1.0 H2 A:X6R402 2.4 0.0 1.0 H3 A:X6R402 2.6 0.0 1.0 N1 A:X6R402 2.8 0.0 1.0 HE21 B:GLN351 3.0 100.0 1.0 OE1 A:GLN351 3.1 100.0 1.0 HB3 A:GLN351 3.2 100.0 1.0 HG2 B:GLN351 3.2 100.0 1.0 HB3 B:GLN351 3.2 100.0 1.0 NE2 B:GLN351 3.3 100.0 1.0 HB2 A:GLN351 3.3 100.0 1.0 C16 B:X6R401 3.4 0.0 1.0 C1 B:X6R401 3.5 0.0 1.0 CD B:GLN351 3.6 100.0 1.0 C4 A:X6R402 3.6 0.0 1.0 C15 B:X6R401 3.6 0.0 1.0 C16 A:X6R402 3.6 0.0 1.0 CB A:GLN351 3.7 100.0 1.0 CG B:GLN351 3.7 100.0 1.0 HE22 B:GLN351 3.7 100.0 1.0 H1 A:X6R402 3.7 0.0 1.0 CD A:GLN351 3.8 100.0 1.0 C5 B:X6R401 3.8 0.0 1.0 H11 B:X6R401 3.9 0.0 1.0 N1 B:X6R401 3.9 0.0 1.0 CB B:GLN351 4.0 100.0 1.0 H1 B:X6R401 4.0 0.0 1.0 C2 B:X6R401 4.1 0.0 1.0 C5 A:X6R402 4.1 0.0 1.0 HA B:GLN351 4.2 100.0 1.0 C7 B:X6R401 4.2 0.0 1.0 C4 B:X6R401 4.3 0.0 1.0 CG A:GLN351 4.4 100.0 1.0 OE1 B:GLN351 4.4 100.0 1.0 H2 B:X6R401 4.4 0.0 1.0 C6 B:X6R401 4.4 0.0 1.0 C3 B:X6R401 4.4 0.0 1.0 NE2 A:GLN351 4.5 100.0 1.0 H4 A:X6R402 4.5 0.0 1.0 HE22 A:GLN351 4.5 100.0 1.0 N2 B:X6R401 4.6 0.0 1.0 CA B:GLN351 4.7 100.0 1.0 HG3 B:GLN351 4.7 100.0 1.0 F B:X6R401 4.8 0.0 1.0 HB2 B:GLN351 4.8 100.0 1.0 C15 A:X6R402 4.8 0.0 1.0 O A:GLN351 4.8 100.0 1.0 CA A:GLN351 5.0 100.0 1.0 H B:SER352 5.0 100.0 1.0 H11 A:X6R402 5.0 0.0 1.0

Fluorine binding site 3 out of 6 in the Alzheimer'S Disease Phf Complexed with Pet Ligand Mk-6240


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Alzheimer'S Disease Phf Complexed with Pet Ligand Mk-6240 within 5.0Å range: probe atom residue distance (Å) B Occ B:F401 b:0.0 occ:1.00 F B:X6R401 0.0 0.0 1.0 C2 B:X6R401 1.4 0.0 1.0 C1 B:X6R401 2.4 0.0 1.0 C3 B:X6R401 2.4 0.0 1.0 H2 B:X6R401 2.4 0.0 1.0 H3 B:X6R401 2.6 0.0 1.0 N1 B:X6R401 2.8 0.0 1.0 HE21 A:GLN351 2.8 100.0 1.0 OE1 F:GLN351 3.1 100.0 1.0 HG2 A:GLN351 3.1 100.0 1.0 HB3 F:GLN351 3.1 100.0 1.0 HB3 A:GLN351 3.2 100.0 1.0 NE2 A:GLN351 3.2 100.0 1.0 HB2 F:GLN351 3.2 100.0 1.0 C16 A:X6R401 3.4 0.0 1.0 C1 A:X6R401 3.6 0.0 1.0 CD A:GLN351 3.6 100.0 1.0 C4 B:X6R401 3.6 0.0 1.0 C16 B:X6R401 3.6 0.0 1.0 CB F:GLN351 3.7 100.0 1.0 CG A:GLN351 3.7 100.0 1.0 C15 A:X6R401 3.7 0.0 1.0 CD F:GLN351 3.7 100.0 1.0 H1 B:X6R401 3.7 0.0 1.0 HE22 A:GLN351 3.7 100.0 1.0 C5 A:X6R401 3.9 0.0 1.0 H11 A:X6R401 3.9 0.0 1.0 N1 A:X6R401 3.9 0.0 1.0 CB A:GLN351 3.9 100.0 1.0 H1 A:X6R401 4.0 0.0 1.0 C2 A:X6R401 4.1 0.0 1.0 C5 B:X6R401 4.1 0.0 1.0 HA A:GLN351 4.3 100.0 1.0 C7 A:X6R401 4.3 0.0 1.0 CG F:GLN351 4.3 100.0 1.0 C4 A:X6R401 4.4 0.0 1.0 H2 A:X6R401 4.4 0.0 1.0 NE2 F:GLN351 4.4 100.0 1.0 OE1 A:GLN351 4.5 100.0 1.0 C3 A:X6R401 4.5 0.0 1.0 C6 A:X6R401 4.5 0.0 1.0 HE22 F:GLN351 4.5 100.0 1.0 H4 B:X6R401 4.5 0.0 1.0 N2 A:X6R401 4.6 0.0 1.0 HG3 A:GLN351 4.7 100.0 1.0 CA A:GLN351 4.7 100.0 1.0 HB2 A:GLN351 4.8 100.0 1.0 F A:X6R402 4.8 0.0 1.0 F A:X6R401 4.8 0.0 1.0 C15 B:X6R401 4.8 0.0 1.0 O F:GLN351 4.9 100.0 1.0 CA F:GLN351 5.0 100.0 1.0 H11 B:X6R401 5.0 0.0 1.0 HG2 F:GLN351 5.0 100.0 1.0

Fluorine binding site 4 out of 6 in the Alzheimer'S Disease Phf Complexed with Pet Ligand Mk-6240


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Alzheimer'S Disease Phf Complexed with Pet Ligand Mk-6240 within 5.0Å range: probe atom residue distance (Å) B Occ C:F401 b:0.0 occ:1.00 F C:X6R401 0.0 0.0 1.0 C2 C:X6R401 1.4 0.0 1.0 C1 C:X6R401 2.4 0.0 1.0 C3 C:X6R401 2.4 0.0 1.0 H2 C:X6R401 2.4 0.0 1.0 H3 C:X6R401 2.6 0.0 1.0 N1 C:X6R401 2.8 0.0 1.0 HE21 E:GLN351 3.0 100.0 1.0 HG2 E:GLN351 3.1 100.0 1.0 HB3 E:GLN351 3.2 100.0 1.0 NE2 E:GLN351 3.2 100.0 1.0 CD E:GLN351 3.5 100.0 1.0 CG E:GLN351 3.6 100.0 1.0 C4 C:X6R401 3.6 0.0 1.0 C16 C:X6R401 3.6 0.0 1.0 HE22 E:GLN351 3.7 100.0 1.0 H1 C:X6R401 3.7 0.0 1.0 CB E:GLN351 3.9 100.0 1.0 C5 C:X6R401 4.1 0.0 1.0 OE1 E:GLN351 4.3 100.0 1.0 HA E:GLN351 4.3 100.0 1.0 H4 C:X6R401 4.5 0.0 1.0 HG3 E:GLN351 4.6 100.0 1.0 CA E:GLN351 4.7 100.0 1.0 HB2 E:GLN351 4.7 100.0 1.0 F D:X6R401 4.8 0.0 1.0 C15 C:X6R401 4.8 0.0 1.0 H11 C:X6R401 5.0 0.0 1.0

Fluorine binding site 5 out of 6 in the Alzheimer'S Disease Phf Complexed with Pet Ligand Mk-6240


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Alzheimer'S Disease Phf Complexed with Pet Ligand Mk-6240 within 5.0Å range: probe atom residue distance (Å) B Occ C:F402 b:0.0 occ:1.00 F C:X6R402 0.0 0.0 1.0 C2 C:X6R402 1.4 0.0 1.0 C1 C:X6R402 2.4 0.0 1.0 C3 C:X6R402 2.4 0.0 1.0 H2 C:X6R402 2.4 0.0 1.0 H3 C:X6R402 2.6 0.0 1.0 N1 C:X6R402 2.8 0.0 1.0 HE21 D:GLN351 3.1 100.0 1.0 HB3 C:GLN351 3.1 100.0 1.0 HB3 D:GLN351 3.1 100.0 1.0 HG2 D:GLN351 3.2 100.0 1.0 OE1 C:GLN351 3.2 100.0 1.0 HB2 C:GLN351 3.2 100.0 1.0 NE2 D:GLN351 3.4 100.0 1.0 C16 D:X6R401 3.4 0.0 1.0 C1 D:X6R401 3.6 0.0 1.0 CD D:GLN351 3.6 100.0 1.0 C4 C:X6R402 3.6 0.0 1.0 CB C:GLN351 3.6 100.0 1.0 C16 C:X6R402 3.6 0.0 1.0 CG D:GLN351 3.7 100.0 1.0 C15 D:X6R401 3.7 0.0 1.0 H1 C:X6R402 3.7 0.0 1.0 CD C:GLN351 3.8 100.0 1.0 C5 D:X6R401 3.8 0.0 1.0 HE22 D:GLN351 3.8 100.0 1.0 CB D:GLN351 3.9 100.0 1.0 N1 D:X6R401 3.9 0.0 1.0 H11 D:X6R401 4.0 0.0 1.0 C2 D:X6R401 4.1 0.0 1.0 H1 D:X6R401 4.1 0.0 1.0 C5 C:X6R402 4.1 0.0 1.0 HA D:GLN351 4.2 100.0 1.0 C7 D:X6R401 4.3 0.0 1.0 C4 D:X6R401 4.3 0.0 1.0 CG C:GLN351 4.3 100.0 1.0 OE1 D:GLN351 4.4 100.0 1.0 C3 D:X6R401 4.4 0.0 1.0 C6 D:X6R401 4.4 0.0 1.0 H2 D:X6R401 4.5 0.0 1.0 NE2 C:GLN351 4.5 100.0 1.0 H4 C:X6R402 4.5 0.0 1.0 HE22 C:GLN351 4.5 100.0 1.0 N2 D:X6R401 4.6 0.0 1.0 CA D:GLN351 4.6 100.0 1.0 HG3 D:GLN351 4.7 100.0 1.0 HB2 D:GLN351 4.7 100.0 1.0 O C:GLN351 4.8 100.0 1.0 F D:X6R401 4.8 0.0 1.0 C15 C:X6R402 4.8 0.0 1.0 CA C:GLN351 4.9 100.0 1.0 H D:SER352 4.9 100.0 1.0 C C:GLN351 5.0 100.0 1.0 H11 C:X6R402 5.0 0.0 1.0

Fluorine binding site 6 out of 6 in the Alzheimer'S Disease Phf Complexed with Pet Ligand Mk-6240


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Alzheimer'S Disease Phf Complexed with Pet Ligand Mk-6240 within 5.0Å range: probe atom residue distance (Å) B Occ D:F401 b:0.0 occ:1.00 F D:X6R401 0.0 0.0 1.0 C2 D:X6R401 1.4 0.0 1.0 C1 D:X6R401 2.4 0.0 1.0 C3 D:X6R401 2.4 0.0 1.0 H2 D:X6R401 2.4 0.0 1.0 H3 D:X6R401 2.6 0.0 1.0 N1 D:X6R401 2.8 0.0 1.0 HE21 C:GLN351 2.8 100.0 1.0 OE1 E:GLN351 2.9 100.0 1.0 NE2 C:GLN351 3.2 100.0 1.0 HG2 C:GLN351 3.2 100.0 1.0 HB3 C:GLN351 3.2 100.0 1.0 HB3 E:GLN351 3.2 100.0 1.0 HB2 E:GLN351 3.3 100.0 1.0 C16 C:X6R401 3.4 0.0 1.0 C1 C:X6R401 3.5 0.0 1.0 CD C:GLN351 3.6 100.0 1.0 C15 C:X6R401 3.6 0.0 1.0 C4 D:X6R401 3.6 0.0 1.0 C16 D:X6R401 3.6 0.0 1.0 HE22 C:GLN351 3.7 100.0 1.0 CG C:GLN351 3.7 100.0 1.0 CD E:GLN351 3.7 100.0 1.0 CB E:GLN351 3.7 100.0 1.0 H1 D:X6R401 3.7 0.0 1.0 H11 C:X6R401 3.8 0.0 1.0 C5 C:X6R401 3.9 0.0 1.0 N1 C:X6R401 3.9 0.0 1.0 CB C:GLN351 3.9 100.0 1.0 H1 C:X6R401 4.0 0.0 1.0 C2 C:X6R401 4.1 0.0 1.0 C5 D:X6R401 4.1 0.0 1.0 C7 C:X6R401 4.2 0.0 1.0 HA C:GLN351 4.3 100.0 1.0 CG E:GLN351 4.3 100.0 1.0 C4 C:X6R401 4.4 0.0 1.0 H2 C:X6R401 4.4 0.0 1.0 C6 C:X6R401 4.4 0.0 1.0 C3 C:X6R401 4.5 0.0 1.0 OE1 C:GLN351 4.5 100.0 1.0 H4 D:X6R401 4.5 0.0 1.0 NE2 E:GLN351 4.5 100.0 1.0 HE22 E:GLN351 4.6 100.0 1.0 N2 C:X6R401 4.6 0.0 1.0 CA C:GLN351 4.7 100.0 1.0 HG3 C:GLN351 4.7 100.0 1.0 HB2 C:GLN351 4.8 100.0 1.0 F C:X6R402 4.8 0.0 1.0 F C:X6R401 4.8 0.0 1.0 C15 D:X6R401 4.8 0.0 1.0 O E:GLN351 5.0 100.0 1.0 H11 D:X6R401 5.0 0.0 1.0

P.Kunach, S.H.Shahmoradian, M.I.Diamond, P.Rosa-Neto. Alzheimer'S Disease Phf Complexed with Pet Ligand Mk-6240 Biorxiv 2023.
ISSN: ISSN 2692-8205
DOI: 10.1101/2023.09.22.558671