Fluorine in PDB 8uqn: PLCB3-Gaq Complex on Membranes

All present enzymatic activity of PLCB3-Gaq Complex on Membranes:
3.1.4.11;

The structure of PLCB3-Gaq Complex on Membranes also contains other interesting chemical elements:

Magnesium	(Mg)	1 atom
Aluminium	(Al)	1 atom
Calcium	(Ca)	1 atom

The binding sites of Fluorine atom in the PLCB3-Gaq Complex on Membranes (pdb code 8uqn). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the PLCB3-Gaq Complex on Membranes, PDB code: 8uqn:
Jump to Fluorine binding site number: 1; 2; 3; 4;

Fluorine binding site 1 out of 4 in the PLCB3-Gaq Complex on Membranes


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of PLCB3-Gaq Complex on Membranes within 5.0Å range: probe atom residue distance (Å) B Occ A:F402 b:72.8 occ:1.00 F1 A:ALF402 0.0 72.8 1.0 AL A:ALF402 1.8 72.8 1.0 F3 A:ALF402 2.5 72.8 1.0 F4 A:ALF402 2.5 72.8 1.0 O2B A:GDP401 2.6 67.3 1.0 O1B A:GDP401 2.6 67.3 1.0 OG1 A:THR186 2.6 66.4 1.0 MG A:MG403 2.8 67.9 1.0 PB A:GDP401 2.8 67.3 1.0 CB A:THR186 3.0 66.4 1.0 O3B A:GDP401 3.0 67.3 1.0 O A:HOH501 3.1 20.0 1.0 H2 A:HOH501 3.1 20.0 1.0 N A:THR186 3.5 66.4 1.0 F2 A:ALF402 3.6 72.8 1.0 H1 A:HOH501 3.7 20.0 1.0 CA A:THR186 3.8 66.4 1.0 O A:VAL206 3.9 61.7 1.0 O A:THR186 4.2 66.4 1.0 CA A:GLY207 4.2 63.4 1.0 CG2 A:THR186 4.2 66.4 1.0 CE A:LYS52 4.4 62.7 1.0 C A:THR186 4.4 66.4 1.0 O3A A:GDP401 4.4 67.3 1.0 N A:GLY208 4.4 65.5 1.0 C A:GLY207 4.5 63.4 1.0 OG A:SER53 4.6 64.7 1.0 C A:PRO185 4.7 67.9 1.0 C A:VAL206 4.8 61.7 1.0 NZ A:LYS52 4.9 62.7 1.0 N A:GLY207 5.0 63.4 1.0 NH1 A:ARG183 5.0 67.5 1.0

Fluorine binding site 2 out of 4 in the PLCB3-Gaq Complex on Membranes


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of PLCB3-Gaq Complex on Membranes within 5.0Å range: probe atom residue distance (Å) B Occ A:F402 b:72.8 occ:1.00 F2 A:ALF402 0.0 72.8 1.0 AL A:ALF402 1.8 72.8 1.0 F4 A:ALF402 2.5 72.8 1.0 F3 A:ALF402 2.5 72.8 1.0 O A:HOH501 2.7 20.0 1.0 O3B A:GDP401 2.9 67.3 1.0 NE2 A:GLN209 3.1 70.5 1.0 N A:GLU49 3.2 73.2 1.0 H2 A:HOH501 3.2 20.0 1.0 OE1 A:GLN209 3.3 70.5 1.0 CA A:GLY48 3.5 72.1 1.0 H1 A:HOH501 3.5 20.0 1.0 F1 A:ALF402 3.6 72.8 1.0 CD A:GLN209 3.6 70.5 1.0 O2B A:GDP401 3.6 67.3 1.0 NH2 A:ARG183 3.6 67.5 1.0 NH1 A:ARG183 3.8 67.5 1.0 C A:GLY48 3.9 72.1 1.0 PB A:GDP401 3.9 67.3 1.0 CA A:GLU49 4.1 73.2 1.0 CZ A:ARG183 4.2 67.5 1.0 N A:GLY208 4.5 65.5 1.0 CA A:GLY208 4.7 65.5 1.0 CG A:GLU49 4.7 73.2 1.0 N A:GLY48 4.8 72.1 1.0 O1B A:GDP401 4.8 67.3 1.0 O A:THR47 4.9 69.5 1.0 CB A:GLU49 5.0 73.2 1.0 O3A A:GDP401 5.0 67.3 1.0

Fluorine binding site 3 out of 4 in the PLCB3-Gaq Complex on Membranes


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of PLCB3-Gaq Complex on Membranes within 5.0Å range: probe atom residue distance (Å) B Occ A:F402 b:72.8 occ:1.00 F3 A:ALF402 0.0 72.8 1.0 AL A:ALF402 1.8 72.8 1.0 O2B A:GDP401 2.3 67.3 1.0 F1 A:ALF402 2.5 72.8 1.0 F2 A:ALF402 2.5 72.8 1.0 O A:HOH501 3.0 20.0 1.0 N A:GLY208 3.0 65.5 1.0 CA A:GLY208 3.3 65.5 1.0 NZ A:LYS52 3.3 62.7 1.0 CE A:LYS52 3.4 62.7 1.0 PB A:GDP401 3.5 67.3 1.0 O3B A:GDP401 3.5 67.3 1.0 H1 A:HOH501 3.5 20.0 1.0 F4 A:ALF402 3.6 72.8 1.0 C A:GLY207 3.6 63.4 1.0 H2 A:HOH501 3.7 20.0 1.0 O A:THR47 3.7 69.5 1.0 CA A:GLY48 3.9 72.1 1.0 CA A:GLY207 4.1 63.4 1.0 N A:GLU49 4.2 73.2 1.0 O1B A:GDP401 4.2 67.3 1.0 O A:GLY207 4.2 63.4 1.0 C A:GLY208 4.4 65.5 1.0 OE1 A:GLN209 4.4 70.5 1.0 C A:THR47 4.4 69.5 1.0 O A:VAL206 4.6 61.7 1.0 C A:GLY48 4.6 72.1 1.0 N A:GLY48 4.6 72.1 1.0 O3A A:GDP401 4.7 67.3 1.0 N A:GLN209 4.8 70.5 1.0 O A:GLY46 4.8 66.2 1.0 CD A:LYS52 4.8 62.7 1.0 MG A:MG403 4.9 67.9 1.0 NE2 A:GLN209 5.0 70.5 1.0

Fluorine binding site 4 out of 4 in the PLCB3-Gaq Complex on Membranes


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of PLCB3-Gaq Complex on Membranes within 5.0Å range: probe atom residue distance (Å) B Occ A:F402 b:72.8 occ:1.00 F4 A:ALF402 0.0 72.8 1.0 AL A:ALF402 1.8 72.8 1.0 O3B A:GDP401 2.3 67.3 1.0 H2 A:HOH501 2.4 20.0 1.0 F2 A:ALF402 2.5 72.8 1.0 F1 A:ALF402 2.5 72.8 1.0 O A:HOH501 2.7 20.0 1.0 N A:THR186 2.9 66.4 1.0 NH1 A:ARG183 3.1 67.5 1.0 CA A:PRO185 3.2 67.9 1.0 PB A:GDP401 3.4 67.3 1.0 C A:PRO185 3.5 67.9 1.0 F3 A:ALF402 3.6 72.8 1.0 CB A:PRO185 3.6 67.9 1.0 O1B A:GDP401 3.6 67.3 1.0 NH2 A:ARG183 3.6 67.5 1.0 H1 A:HOH501 3.7 20.0 1.0 CZ A:ARG183 3.7 67.5 1.0 OG1 A:THR186 3.7 66.4 1.0 O2B A:GDP401 3.8 67.3 1.0 CA A:THR186 3.9 66.4 1.0 CB A:THR186 4.1 66.4 1.0 O A:THR186 4.1 66.4 1.0 OE1 A:GLN209 4.4 70.5 1.0 N A:PRO185 4.4 67.9 1.0 O1A A:GDP401 4.5 67.3 1.0 C A:THR186 4.5 66.4 1.0 O A:VAL184 4.6 67.8 1.0 MG A:MG403 4.6 67.9 1.0 O A:PRO185 4.7 67.9 1.0 O3A A:GDP401 4.7 67.3 1.0 NE2 A:GLN209 4.9 70.5 1.0 NE A:ARG183 4.9 67.5 1.0 C A:VAL184 4.9 67.8 1.0 CG A:PRO185 5.0 67.9 1.0

M.E.Falzone, R.Mackinnon. The Mechanism of G Alpha Q Regulation of Plc Beta 3 -Catalyzed PIP2 Hydrolysis. Proc.Natl.Acad.Sci.Usa V. 120 11120 2023.
ISSN: ESSN 1091-6490
PubMed: 37991948
DOI: 10.1073/PNAS.2315011120