Fluorine in PDB 8w03: Crystal Structure of the Er-Alpha Ligand-Binding Domain (L372S, L536S) in Complex with K-1154
Protein crystallography data
The structure of Crystal Structure of the Er-Alpha Ligand-Binding Domain (L372S, L536S) in Complex with K-1154, PDB code: 8w03
was solved by
C.K.Min,
J.C.Nwachukwu,
Y.Hou,
R.J.Russo,
A.Papa,
J.Min,
R.Peng,
S.H.Kim,
Y.Ziegler,
E.S.Rangarajan,
T.Izard,
B.S.Katzenellenbogen,
J.A.Katzenellenbogen,
K.W.Nettles,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 38.36 / 1.68 |
| Space group | P 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 53.489, 58.771, 93.208, 86.61, 75.17, 62.96 |
| R / Rfree (%) | 20.1 / 24.5 |
Other elements in 8w03:
The structure of Crystal Structure of the Er-Alpha Ligand-Binding Domain (L372S, L536S) in Complex with K-1154 also contains other interesting chemical elements:
| Chlorine | (Cl) | 3 atoms |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of the Er-Alpha Ligand-Binding Domain (L372S, L536S) in Complex with K-1154
(pdb code 8w03). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Crystal Structure of the Er-Alpha Ligand-Binding Domain (L372S, L536S) in Complex with K-1154, PDB code: 8w03:
Jump to Fluorine binding site number: 1; 2; 3;
In total 3 binding sites of Fluorine where determined in the Crystal Structure of the Er-Alpha Ligand-Binding Domain (L372S, L536S) in Complex with K-1154, PDB code: 8w03:
Jump to Fluorine binding site number: 1; 2; 3;
Fluorine binding site 1 out of 3 in 8w03
Go back to
Fluorine Binding Sites List in 8w03
Fluorine binding site 1 out
of 3 in the Crystal Structure of the Er-Alpha Ligand-Binding Domain (L372S, L536S) in Complex with K-1154
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of the Er-Alpha Ligand-Binding Domain (L372S, L536S) in Complex with K-1154 within 5.0Å range:
|
Fluorine binding site 2 out of 3 in 8w03
Go back to
Fluorine Binding Sites List in 8w03
Fluorine binding site 2 out
of 3 in the Crystal Structure of the Er-Alpha Ligand-Binding Domain (L372S, L536S) in Complex with K-1154
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of the Er-Alpha Ligand-Binding Domain (L372S, L536S) in Complex with K-1154 within 5.0Å range:
|
Fluorine binding site 3 out of 3 in 8w03
Go back to
Fluorine Binding Sites List in 8w03
Fluorine binding site 3 out
of 3 in the Crystal Structure of the Er-Alpha Ligand-Binding Domain (L372S, L536S) in Complex with K-1154
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of the Er-Alpha Ligand-Binding Domain (L372S, L536S) in Complex with K-1154 within 5.0Å range:
|
Reference:
C.K.Min,
J.C.Nwachukwu,
Y.Hou,
R.J.Russo,
A.Papa,
J.Min,
R.Peng,
S.H.Kim,
Y.Ziegler,
E.S.Rangarajan,
T.Izard,
B.S.Katzenellenbogen,
J.A.Katzenellenbogen,
K.W.Nettles.
Asymmetric Allostery in Estrogen Receptor-Alpha Homodimers Drives Responses to the Ensemble of Estrogens in the Hormonal Milieu. Proc.Natl.Acad.Sci.Usa V. 121 44121 2024.
ISSN: ESSN 1091-6490
PubMed: 38830107
DOI: 10.1073/PNAS.2321344121
Page generated: Sat Aug 3 01:32:50 2024
ISSN: ESSN 1091-6490
PubMed: 38830107
DOI: 10.1073/PNAS.2321344121
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