Fluorine in PDB 8w7c: Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality

Enzymatic activity of Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality

All present enzymatic activity of Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality:
3.4.21.92;

Protein crystallography data

The structure of Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality, PDB code: 8w7c was solved by J.-X.Jiang, H.Ding, M.-L.Lu, M.-R.Chen, H.-Y.Sun, Y.-B.Xiao, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 46.20 / 3.00
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 142.245, 153.591, 104.617, 90, 117.96, 90
R / Rfree (%) 24 / 26

Other elements in 8w7c:

The structure of Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality also contains other interesting chemical elements:

Chlorine (Cl) 7 atoms

Fluorine Binding Sites:

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 20; Page 3, Binding sites: 21 - 21;

Binding sites:

The binding sites of Fluorine atom in the Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality (pdb code 8w7c). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 21 binding sites of Fluorine where determined in the Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality, PDB code: 8w7c:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Fluorine binding site 1 out of 21 in 8w7c

Go back to Fluorine Binding Sites List in 8w7c
Fluorine binding site 1 out of 21 in the Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F301

b:66.0
occ:1.00
 F09 A:R89301 0.0 66.0 1.0
C10 A:R89301 1.4 65.2 1.0
F11 A:R89301 2.2 65.0 1.0
F12 A:R89301 2.2 66.1 1.0
C06 A:R89301 2.4 64.5 1.0
CD2 A:LEU79 3.1 50.1 1.0
O A:ARG78 3.2 61.8 1.0
CA A:LEU79 3.3 48.7 1.0
C05 A:R89301 3.3 64.2 1.0
N A:LEU79 3.3 49.9 1.0
C07 A:R89301 3.3 65.3 1.0
C A:ARG78 3.4 60.4 1.0
CG A:ARG78 3.4 59.5 1.0
CG A:LEU79 3.8 50.0 1.0
CG A:GLU82 4.0 59.9 1.0
CB A:ARG78 4.1 59.4 1.0
CB A:LEU79 4.1 50.4 1.0
NE A:ARG78 4.3 64.5 1.0
CA A:ARG78 4.4 59.2 1.0
CD A:ARG78 4.4 62.7 1.0
C A:LEU79 4.5 48.4 1.0
CB A:GLU82 4.5 58.3 1.0
C04 A:R89301 4.7 64.5 1.0
C08 A:R89301 4.7 67.5 1.0
O A:ILE75 4.7 55.7 1.0
CZ A:ARG78 4.8 65.3 1.0
O A:LEU79 4.8 49.1 1.0

Fluorine binding site 2 out of 21 in 8w7c

Go back to Fluorine Binding Sites List in 8w7c
Fluorine binding site 2 out of 21 in the Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F301

b:65.0
occ:1.00
 F11 A:R89301 0.0 65.0 1.0
C10 A:R89301 1.4 65.2 1.0
F12 A:R89301 2.2 66.1 1.0
F09 A:R89301 2.2 66.0 1.0
C06 A:R89301 2.4 64.5 1.0
C05 A:R89301 2.8 64.2 1.0
CD1 F:PHE105 3.2 47.1 1.0
CG A:ARG78 3.4 59.5 1.0
C07 A:R89301 3.8 65.3 1.0
CB F:PHE105 3.8 46.4 1.0
CZ A:ARG78 3.8 65.3 1.0
NH1 A:ARG78 3.9 64.9 1.0
CA F:PHE105 3.9 47.0 1.0
CG F:PHE105 3.9 47.0 1.0
NE A:ARG78 4.0 64.5 1.0
OG F:SER108 4.1 55.2 1.0
CE1 F:PHE105 4.2 46.3 1.0
NH2 A:ARG78 4.3 65.4 1.0
CD A:ARG78 4.3 62.7 1.0
C04 A:R89301 4.3 64.5 1.0
CB A:ARG78 4.5 59.4 1.0
O A:ARG78 4.7 61.8 1.0
N F:PHE105 4.7 47.3 1.0
CG A:GLU82 4.7 59.9 1.0
C A:ARG78 4.9 60.4 1.0
CD2 A:LEU79 4.9 50.1 1.0
O F:PHE105 4.9 47.7 1.0
C F:PHE105 4.9 48.1 1.0
C08 A:R89301 5.0 67.5 1.0

Fluorine binding site 3 out of 21 in 8w7c

Go back to Fluorine Binding Sites List in 8w7c
Fluorine binding site 3 out of 21 in the Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F301

b:66.1
occ:1.00
 F12 A:R89301 0.0 66.1 1.0
C10 A:R89301 1.4 65.2 1.0
F11 A:R89301 2.2 65.0 1.0
F09 A:R89301 2.2 66.0 1.0
C06 A:R89301 2.4 64.5 1.0
C07 A:R89301 2.9 65.3 1.0
CB F:PHE105 3.1 46.4 1.0
CD2 A:LEU79 3.4 50.1 1.0
CA F:PHE105 3.4 47.0 1.0
O F:ALA101 3.6 44.2 1.0
N F:PHE105 3.7 47.3 1.0
C05 A:R89301 3.7 64.2 1.0
CD1 F:PHE105 4.0 47.1 1.0
CG F:PHE105 4.0 47.0 1.0
CG A:LEU79 4.2 50.0 1.0
C08 A:R89301 4.4 67.5 1.0
C F:LEU104 4.4 51.0 1.0
CG1 A:ILE75 4.5 54.3 1.0
CG A:ARG78 4.6 59.5 1.0
C F:ALA101 4.6 44.1 1.0
O F:LEU104 4.8 51.4 1.0
CB F:LEU104 4.9 50.3 1.0
CD1 A:ILE75 4.9 55.8 1.0
C F:PHE105 4.9 48.1 1.0
N A:LEU79 4.9 49.9 1.0
C04 A:R89301 4.9 64.5 1.0
CA A:LEU79 5.0 48.7 1.0
O A:ILE75 5.0 55.7 1.0

Fluorine binding site 4 out of 21 in 8w7c

Go back to Fluorine Binding Sites List in 8w7c
Fluorine binding site 4 out of 21 in the Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F301

b:61.5
occ:1.00
 F09 B:R89301 0.0 61.5 1.0
C10 B:R89301 1.4 62.1 1.0
F12 B:R89301 2.2 63.5 1.0
F11 B:R89301 2.2 63.0 1.0
C06 B:R89301 2.4 61.2 1.0
C05 B:R89301 3.0 62.9 1.0
CD2 B:LEU79 3.0 54.1 1.0
CG B:LEU79 3.5 53.0 1.0
CA B:LEU79 3.5 52.5 1.0
N B:LEU79 3.6 54.4 1.0
C07 B:R89301 3.6 60.9 1.0
O B:ARG78 3.9 68.3 1.0
C B:ARG78 3.9 68.6 1.0
CB B:LEU79 4.0 53.3 1.0
CG B:ARG78 4.1 67.9 1.0
CG B:GLU82 4.3 69.2 1.0
C04 B:R89301 4.4 62.4 1.0
CB B:ARG78 4.5 68.0 1.0
O B:ILE75 4.6 52.2 1.0
CB B:GLU82 4.7 67.4 1.0
C B:LEU79 4.8 51.6 1.0
CD1 B:LEU79 4.8 53.2 1.0
CA B:ARG78 4.8 68.2 1.0
C08 B:R89301 4.9 60.3 1.0

Fluorine binding site 5 out of 21 in 8w7c

Go back to Fluorine Binding Sites List in 8w7c
Fluorine binding site 5 out of 21 in the Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F301

b:63.0
occ:1.00
 F11 B:R89301 0.0 63.0 1.0
C10 B:R89301 1.4 62.1 1.0
F09 B:R89301 2.2 61.5 1.0
F12 B:R89301 2.2 63.5 1.0
C06 B:R89301 2.4 61.2 1.0
C07 B:R89301 2.7 60.9 1.0
CG B:ARG78 3.0 67.9 1.0
CZ B:ARG78 3.5 71.4 1.0
NE B:ARG78 3.5 70.2 1.0
NH1 B:ARG78 3.7 71.3 1.0
C05 B:R89301 3.8 62.9 1.0
CG B:GLU82 3.8 69.2 1.0
CD B:ARG78 3.8 68.5 1.0
O B:ARG78 3.9 68.3 1.0
NH2 B:ARG78 3.9 71.5 1.0
CB B:ARG78 4.1 68.0 1.0
C B:ARG78 4.2 68.6 1.0
C08 B:R89301 4.3 60.3 1.0
N B:LEU79 4.7 54.4 1.0
CD B:GLU82 4.7 71.1 1.0
CA B:ARG78 4.8 68.2 1.0
CB B:GLU82 4.9 67.4 1.0
OE2 B:GLU82 4.9 72.0 1.0
CA B:LEU79 5.0 52.5 1.0
C04 B:R89301 5.0 62.4 1.0

Fluorine binding site 6 out of 21 in 8w7c

Go back to Fluorine Binding Sites List in 8w7c
Fluorine binding site 6 out of 21 in the Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F301

b:63.5
occ:1.00
 F12 B:R89301 0.0 63.5 1.0
C10 B:R89301 1.4 62.1 1.0
F09 B:R89301 2.2 61.5 1.0
F11 B:R89301 2.2 63.0 1.0
C06 B:R89301 2.4 61.2 1.0
C05 B:R89301 3.1 62.9 1.0
C07 B:R89301 3.5 60.9 1.0
CG B:ARG78 4.5 67.9 1.0
C04 B:R89301 4.5 62.4 1.0
CD2 B:LEU79 4.7 54.1 1.0
C08 B:R89301 4.8 60.3 1.0

Fluorine binding site 7 out of 21 in 8w7c

Go back to Fluorine Binding Sites List in 8w7c
Fluorine binding site 7 out of 21 in the Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 7 of Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality within 5.0Å range:
probe atom residue distance (Å) B Occ
C:F301

b:58.7
occ:1.00
 F09 C:R89301 0.0 58.7 1.0
C10 C:R89301 1.4 58.0 1.0
F11 C:R89301 2.2 57.9 1.0
F12 C:R89301 2.2 58.5 1.0
C06 C:R89301 2.4 56.9 1.0
O C:ARG78 3.0 66.9 1.0
CD2 C:LEU79 3.1 51.0 1.0
C07 C:R89301 3.2 56.6 1.0
C C:ARG78 3.3 66.1 1.0
CA C:LEU79 3.3 51.0 1.0
N C:LEU79 3.3 52.1 1.0
C05 C:R89301 3.4 56.6 1.0
CG C:ARG78 3.5 65.5 1.0
CG C:GLU82 3.9 62.9 1.0
CG C:LEU79 3.9 51.7 1.0
CB C:ARG78 4.1 66.2 1.0
CB C:LEU79 4.1 53.1 1.0
NH2 C:ARG78 4.2 69.0 1.0
CD C:ARG78 4.3 67.4 1.0
CA C:ARG78 4.3 66.5 1.0
C C:LEU79 4.4 50.5 1.0
CB C:GLU82 4.5 63.2 1.0
C08 C:R89301 4.6 58.5 1.0
O C:LEU79 4.7 50.9 1.0
C04 C:R89301 4.7 55.4 1.0
O C:ILE75 4.7 59.8 1.0
CZ C:ARG78 4.8 69.5 1.0
NE C:ARG78 4.9 68.3 1.0

Fluorine binding site 8 out of 21 in 8w7c

Go back to Fluorine Binding Sites List in 8w7c
Fluorine binding site 8 out of 21 in the Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 8 of Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality within 5.0Å range:
probe atom residue distance (Å) B Occ
C:F301

b:57.9
occ:1.00
 F11 C:R89301 0.0 57.9 1.0
C10 C:R89301 1.4 58.0 1.0
F12 C:R89301 2.2 58.5 1.0
F09 C:R89301 2.2 58.7 1.0
C06 C:R89301 2.4 56.9 1.0
C05 C:R89301 2.8 56.6 1.0
CG C:ARG78 3.2 65.5 1.0
CD1 D:PHE105 3.3 51.0 1.0
C07 C:R89301 3.8 56.6 1.0
NH2 C:ARG78 3.8 69.0 1.0
CB D:PHE105 3.9 48.9 1.0
CZ C:ARG78 3.9 69.5 1.0
NE C:ARG78 4.0 68.3 1.0
CD C:ARG78 4.0 67.4 1.0
CG D:PHE105 4.1 50.0 1.0
CA D:PHE105 4.1 49.6 1.0
C04 C:R89301 4.3 55.4 1.0
CE1 D:PHE105 4.3 50.9 1.0
CB C:ARG78 4.3 66.2 1.0
OG D:SER108 4.4 59.9 1.0
O C:ARG78 4.5 66.9 1.0
NH1 C:ARG78 4.6 71.0 1.0
C C:ARG78 4.7 66.1 1.0
CG C:GLU82 4.7 62.9 1.0
N D:PHE105 4.8 50.1 1.0
CD2 C:LEU79 4.9 51.0 1.0
C08 C:R89301 5.0 58.5 1.0

Fluorine binding site 9 out of 21 in 8w7c

Go back to Fluorine Binding Sites List in 8w7c
Fluorine binding site 9 out of 21 in the Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 9 of Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality within 5.0Å range:
probe atom residue distance (Å) B Occ
C:F301

b:58.5
occ:1.00
 F12 C:R89301 0.0 58.5 1.0
C10 C:R89301 1.4 58.0 1.0
F11 C:R89301 2.2 57.9 1.0
F09 C:R89301 2.2 58.7 1.0
C06 C:R89301 2.3 56.9 1.0
C07 C:R89301 2.9 56.6 1.0
CD2 C:LEU79 3.3 51.0 1.0
CB D:PHE105 3.3 48.9 1.0
CA D:PHE105 3.6 49.6 1.0
O D:ALA101 3.6 42.5 1.0
C05 C:R89301 3.7 56.6 1.0
N D:PHE105 3.7 50.1 1.0
CD1 D:PHE105 4.2 51.0 1.0
CG D:PHE105 4.3 50.0 1.0
CG C:LEU79 4.3 51.7 1.0
C08 C:R89301 4.4 58.5 1.0
C D:LEU104 4.4 47.6 1.0
CG C:ARG78 4.5 65.5 1.0
CG1 C:ILE75 4.6 57.8 1.0
C D:ALA101 4.6 42.4 1.0
O D:LEU104 4.8 48.1 1.0
CB D:LEU104 4.8 46.4 1.0
C04 C:R89301 4.9 55.4 1.0
N C:LEU79 4.9 52.1 1.0
CA C:LEU79 4.9 51.0 1.0
CD1 C:ILE75 5.0 59.4 1.0

Fluorine binding site 10 out of 21 in 8w7c

Go back to Fluorine Binding Sites List in 8w7c
Fluorine binding site 10 out of 21 in the Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 10 of Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality within 5.0Å range:
probe atom residue distance (Å) B Occ
D:F301

b:61.8
occ:1.00
 F09 D:R89301 0.0 61.8 1.0
C10 D:R89301 1.4 61.2 1.0
F12 D:R89301 2.2 59.5 1.0
F11 D:R89301 2.2 59.9 1.0
C06 D:R89301 2.4 61.1 1.0
O D:ARG78 3.1 68.2 1.0
C07 D:R89301 3.2 59.8 1.0
C D:ARG78 3.3 67.1 1.0
CA D:LEU79 3.3 42.4 1.0
CG D:ARG78 3.4 67.8 1.0
N D:LEU79 3.4 42.4 1.0
CD2 D:LEU79 3.4 42.6 1.0
C05 D:R89301 3.4 60.4 1.0
CG D:GLU82 3.8 66.2 1.0
CG D:LEU79 4.0 42.4 1.0
CB D:ARG78 4.1 67.4 1.0
NH2 D:ARG78 4.1 70.2 1.0
CB D:LEU79 4.2 42.3 1.0
CB D:GLU82 4.3 65.7 1.0
CA D:ARG78 4.3 67.8 1.0
C D:LEU79 4.4 42.4 1.0
CD D:ARG78 4.4 68.8 1.0
CZ D:ARG78 4.5 70.6 1.0
C08 D:R89301 4.5 61.3 1.0
NE D:ARG78 4.6 69.5 1.0
O D:LEU79 4.7 42.7 1.0
C04 D:R89301 4.7 59.8 1.0
O D:ILE75 4.8 48.8 1.0

Reference:

J.-X.Jiang, H.Ding, M.-L.Lu, M.-R.Chen, H.-Y.Sun, Y.-B.Xiao. Activation of Mitochondrial Caseinolytic Protease P (Clpp) Induces Selective Cancer Cell Lethality To Be Published.
Page generated: Sat Sep 28 20:37:53 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy