Fluorine in PDB 8w9b: Cryoem Structure of Human PI3K-Alpha (P85/P110-H1047R) with Qr-8557 Binding at An Allosteric Site

All present enzymatic activity of Cryoem Structure of Human PI3K-Alpha (P85/P110-H1047R) with Qr-8557 Binding at An Allosteric Site:
2.7.1.137; 2.7.1.153; 2.7.11.1;

The binding sites of Fluorine atom in the Cryoem Structure of Human PI3K-Alpha (P85/P110-H1047R) with Qr-8557 Binding at An Allosteric Site (pdb code 8w9b). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Cryoem Structure of Human PI3K-Alpha (P85/P110-H1047R) with Qr-8557 Binding at An Allosteric Site, PDB code: 8w9b:

Fluorine binding site 1 out of 1 in the Cryoem Structure of Human PI3K-Alpha (P85/P110-H1047R) with Qr-8557 Binding at An Allosteric Site


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryoem Structure of Human PI3K-Alpha (P85/P110-H1047R) with Qr-8557 Binding at An Allosteric Site within 5.0Å range: probe atom residue distance (Å) B Occ A:F1101 b:19.0 occ:1.00 F27 A:UJ31101 0.0 19.0 1.0 C26 A:UJ31101 1.4 19.0 1.0 C25 A:UJ31101 2.4 19.0 1.0 C28 A:UJ31101 2.4 19.0 1.0 H251 A:UJ31101 2.6 19.0 1.0 H281 A:UJ31101 2.6 19.0 1.0 O A:GLN809 2.7 23.6 1.0 NE2 A:GLN809 3.0 23.6 1.0 CA A:GLN809 3.1 23.6 1.0 CG A:GLN809 3.2 23.6 1.0 C A:GLN809 3.3 23.6 1.0 CD A:GLN809 3.6 23.6 1.0 C29 A:UJ31101 3.7 19.0 1.0 C24 A:UJ31101 3.7 19.0 1.0 CB A:GLN809 3.7 23.6 1.0 O A:ARG808 4.0 20.2 1.0 C23 A:UJ31101 4.2 19.0 1.0 CB A:LEU812 4.2 23.8 1.0 OG1 A:THR813 4.2 33.7 1.0 CD2 A:LEU812 4.2 23.8 1.0 N A:GLN809 4.2 23.6 1.0 H291 A:UJ31101 4.4 19.0 1.0 C A:ARG808 4.6 20.2 1.0 SD A:MET1010 4.6 22.6 1.0 N A:ASP810 4.7 27.4 1.0 CG A:LEU812 4.7 23.8 1.0 OE1 A:GLN809 4.8 23.6 1.0 N A:THR813 4.8 33.7 1.0 C02 A:UJ31101 5.0 19.0 1.0

X.Huang, K.Wang, J.Han, X.Chen, Z.Wang, T.Wu, B.Yu, F.Zhao, X.Wang, H.Li, Z.Xie, X.Zhu, W.Zhong, X.Ren. Cryo-Em Structures Reveal Two Allosteric Inhibition Modes of PI3K Alpha H1047R Involving A Re-Shaping of the Activation Loop. Structure 2024.
ISSN: ISSN 0969-2126
PubMed: 38582077
DOI: 10.1016/J.STR.2024.03.007