Fluorine in PDB 8wfj: Human Glycine Transporter 1 in Complex with Alx-5407 in Inward Facing Conformation

The binding sites of Fluorine atom in the Human Glycine Transporter 1 in Complex with Alx-5407 in Inward Facing Conformation (pdb code 8wfj). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Human Glycine Transporter 1 in Complex with Alx-5407 in Inward Facing Conformation, PDB code: 8wfj:

Fluorine binding site 1 out of 1 in the Human Glycine Transporter 1 in Complex with Alx-5407 in Inward Facing Conformation


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Human Glycine Transporter 1 in Complex with Alx-5407 in Inward Facing Conformation within 5.0Å range: probe atom residue distance (Å) B Occ A:F701 b:70.0 occ:1.00 F01 A:W5F701 0.0 70.0 1.0 C20 A:W5F701 1.4 73.0 1.0 C16 A:W5F701 2.4 69.5 1.0 C15 A:W5F701 2.4 73.5 1.0 N A:GLY324 3.0 68.5 1.0 CA A:GLY324 3.3 70.8 1.0 CB A:TRP322 3.3 53.0 1.0 CE3 A:TRP322 3.4 65.0 1.0 C13 A:W5F701 3.6 70.8 1.0 C12 A:W5F701 3.6 77.1 1.0 CD2 A:TRP322 4.0 59.8 1.0 CG A:TRP322 4.1 55.9 1.0 C A:GLY324 4.1 65.5 1.0 C A:TRP322 4.1 58.4 1.0 C09 A:W5F701 4.1 78.6 1.0 N A:GLY323 4.2 63.1 1.0 C A:GLY323 4.2 74.3 1.0 CA A:TRP322 4.3 56.0 1.0 N A:LEU325 4.3 66.2 1.0 O A:TRP322 4.4 67.6 1.0 CZ3 A:TRP322 4.4 62.1 1.0 CD1 A:LEU422 4.7 40.2 1.0 CA A:LEU422 4.7 54.5 1.0 CA A:GLY323 4.7 68.5 1.0 OG A:SER135 4.7 42.8 1.0 CB A:LEU422 4.8 59.2 1.0 SG A:CYS421 4.9 69.8 1.0 O A:GLY324 5.0 61.7 1.0

Y.Wei, R.Li, Y.Meng, T.Hu, J.Zhao, Y.Gao, Q.Bai, N.Li, Y.Zhao. Transport Mechanism and Pharmacology of the Human GLYT1. Cell 2024.
ISSN: ISSN 1097-4172
PubMed: 38513663
DOI: 10.1016/J.CELL.2024.02.026