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Fluorine in PDB 8wy3: Crystal Structure of the First Bromodomain of Human BRD4 in Complex with the Inhibitor 21Protein crystallography data
The structure of Crystal Structure of the First Bromodomain of Human BRD4 in Complex with the Inhibitor 21, PDB code: 8wy3
was solved by
H.Xu,
X.Zhao,
H.Shen,
Y.Xu,
X.Wu,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of the First Bromodomain of Human BRD4 in Complex with the Inhibitor 21
(pdb code 8wy3). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Crystal Structure of the First Bromodomain of Human BRD4 in Complex with the Inhibitor 21, PDB code: 8wy3: Jump to Fluorine binding site number: 1; 2; 3; Fluorine binding site 1 out of 3 in 8wy3Go back to Fluorine Binding Sites List in 8wy3
Fluorine binding site 1 out
of 3 in the Crystal Structure of the First Bromodomain of Human BRD4 in Complex with the Inhibitor 21
Mono view Stereo pair view
Fluorine binding site 2 out of 3 in 8wy3Go back to Fluorine Binding Sites List in 8wy3
Fluorine binding site 2 out
of 3 in the Crystal Structure of the First Bromodomain of Human BRD4 in Complex with the Inhibitor 21
Mono view Stereo pair view
Fluorine binding site 3 out of 3 in 8wy3Go back to Fluorine Binding Sites List in 8wy3
Fluorine binding site 3 out
of 3 in the Crystal Structure of the First Bromodomain of Human BRD4 in Complex with the Inhibitor 21
Mono view Stereo pair view
Reference:
W.Jiang,
Q.Hou,
H.Xu,
K.Yang,
X.Wang,
K.Zhang,
Y.Zeng,
W.Li,
B.Wang,
G.Luo,
X.Zhao,
H.Shen,
Y.Xu,
X.Wu.
Discovery of Novel Phenoxyaryl Pyridones As Bromodomain and Extra-Terminal Domain (Bet) Inhibitors with High Selectivity For the Second Bromodomain (BD2) to Potentially Treat Acute Myeloid Leukemia. J.Med.Chem. 2024.
Page generated: Sat Aug 3 01:41:37 2024
ISSN: ISSN 0022-2623 PubMed: 38175809 DOI: 10.1021/ACS.JMEDCHEM.3C02104 |
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