Fluorine in PDB 8zyq: Cryo-Em Structure of Pimozide-Bound Herg Channel

The binding sites of Fluorine atom in the Cryo-Em Structure of Pimozide-Bound Herg Channel (pdb code 8zyq). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Cryo-Em Structure of Pimozide-Bound Herg Channel, PDB code: 8zyq:
Jump to Fluorine binding site number: 1; 2;

Fluorine binding site 1 out of 2 in the Cryo-Em Structure of Pimozide-Bound Herg Channel


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of Pimozide-Bound Herg Channel within 5.0Å range: probe atom residue distance (Å) B Occ B:F1101 b:83.2 occ:1.00 F01 B:1II1101 0.0 83.2 1.0 C33 B:1II1101 1.3 70.6 1.0 C31 B:1II1101 2.3 59.6 1.0 C29 B:1II1101 2.3 70.5 1.0 CA D:TYR652 3.5 67.2 1.0 C27 B:1II1101 3.6 53.6 1.0 C25 B:1II1101 3.6 64.5 1.0 CE D:MET651 3.6 70.6 1.0 CE1 D:PHE656 3.8 94.7 1.0 CB D:TYR652 3.9 68.8 1.0 N D:TYR652 3.9 58.6 1.0 CD1 D:PHE656 4.0 95.2 1.0 C20 B:1II1101 4.1 54.1 1.0 CZ D:PHE656 4.1 88.4 1.0 CE1 D:PHE557 4.4 61.8 1.0 CZ D:PHE557 4.4 67.0 1.0 CG D:PHE656 4.5 98.6 1.0 C D:MET651 4.5 59.4 1.0 CE2 D:PHE656 4.5 92.7 1.0 CD1 D:TYR652 4.6 68.6 1.0 O D:MET651 4.6 67.7 1.0 CD2 D:PHE656 4.7 103.7 1.0 CG D:TYR652 4.7 67.4 1.0 O D:GLY648 4.7 49.6 1.0 C D:TYR652 4.8 70.8 1.0 CD1 D:PHE557 4.8 58.6 1.0 CE2 D:PHE557 5.0 57.0 1.0 O D:TYR652 5.0 81.4 1.0

Fluorine binding site 2 out of 2 in the Cryo-Em Structure of Pimozide-Bound Herg Channel


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Cryo-Em Structure of Pimozide-Bound Herg Channel within 5.0Å range: probe atom residue distance (Å) B Occ B:F1101 b:64.1 occ:1.00 F02 B:1II1101 0.0 64.1 1.0 C34 B:1II1101 1.2 50.6 1.0 C30 B:1II1101 2.2 47.8 1.0 C32 B:1II1101 2.2 54.1 1.0 C B:GLY648 3.1 54.6 1.0 O B:LEU622 3.1 34.7 1.0 CA B:GLY648 3.3 45.7 1.0 O B:GLY648 3.3 63.4 1.0 C26 B:1II1101 3.4 55.2 1.0 N B:SER649 3.5 55.7 1.0 C28 B:1II1101 3.5 58.9 1.0 C21 B:1II1101 4.0 56.2 1.0 C B:LEU622 4.0 27.2 1.0 CB B:TYR652 4.0 61.3 1.0 OG B:SER624 4.1 41.1 1.0 CA B:SER649 4.2 63.5 1.0 CA B:LEU622 4.3 25.1 1.0 O B:MET645 4.4 52.9 1.0 O B:SER621 4.4 20.6 1.0 N B:GLY648 4.5 44.9 1.0 CG B:TYR652 4.5 69.4 1.0 OG1 D:THR623 4.7 51.9 1.0 CD2 B:TYR652 4.9 70.2 1.0

Y.Miyashita, T.Moriya, T.Kato, M.Kawasaki, Y.Yasuda, N.Adachi, K.Suzuki, S.Ogasawara, T.Saito, T.Senda, T.Murata. Improved Higher Resolution Cryo-Em Structures Reveal the Binding Modes of Herg Channel Inhibitors To Be Published.