Fluorine in PDB 9b6e: Cryo-Em Structure of the Mouse TRPM8 Channel in Complex with the Antagonist Tc-I 2014

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 20; Page 3, Binding sites: 21 - 24;

Binding sites:

The binding sites of Fluorine atom in the Cryo-Em Structure of the Mouse TRPM8 Channel in Complex with the Antagonist Tc-I 2014 (pdb code 9b6e). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 24 binding sites of Fluorine where determined in the Cryo-Em Structure of the Mouse TRPM8 Channel in Complex with the Antagonist Tc-I 2014, PDB code: 9b6e:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Fluorine binding site 1 out of 24 in the Cryo-Em Structure of the Mouse TRPM8 Channel in Complex with the Antagonist Tc-I 2014


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of the Mouse TRPM8 Channel in Complex with the Antagonist Tc-I 2014 within 5.0Å range: probe atom residue distance (Å) B Occ A:F1201 b:101.9 occ:1.00 F01 A:T141201 0.0 101.9 1.0 C02 A:T141201 1.3 91.9 1.0 F33 A:T141201 2.2 95.1 1.0 F32 A:T141201 2.2 98.1 1.0 C03 A:T141201 2.4 91.9 1.0 HH2 B:TRP877 2.6 36.9 1.0 C09 A:T141201 2.9 95.7 1.0 C08 A:T141201 3.0 94.8 1.0 C10 A:T141201 3.2 97.9 1.0 HD21 A:LEU860 3.3 61.5 1.0 HD13 B:LEU873 3.3 59.0 1.0 CH2 B:TRP877 3.4 42.8 1.0 H101 A:T141201 3.4 100.4 1.0 C04 A:T141201 3.4 91.0 1.0 HZ2 B:TRP877 3.5 37.1 1.0 C31 A:T141201 3.6 92.8 1.0 HD13 B:LEU971 3.6 56.0 1.0 HG A:LEU860 3.7 62.7 1.0 H041 A:T141201 3.7 99.0 1.0 CZ2 B:TRP877 3.8 40.5 1.0 HD23 A:LEU860 3.9 62.9 1.0 HD22 B:LEU974 3.9 56.6 1.0 CD2 A:LEU860 3.9 49.5 1.0 H311 A:T141201 3.9 100.5 1.0 HD11 B:LEU873 4.0 58.5 1.0 CD1 B:LEU873 4.0 57.9 1.0 C11 A:T141201 4.1 92.5 1.0 C07 A:T141201 4.3 91.8 1.0 C30 A:T141201 4.3 87.3 1.0 CG A:LEU860 4.3 49.6 1.0 HD12 B:LEU873 4.4 57.9 1.0 HD23 B:LEU974 4.4 57.2 1.0 C16 A:T141201 4.5 89.2 1.0 HA B:LEU971 4.5 55.9 1.0 CD1 B:LEU971 4.5 48.3 1.0 CZ3 B:TRP877 4.5 32.3 1.0 HD11 A:LEU860 4.6 63.2 1.0 CD2 B:LEU974 4.6 60.7 1.0 HD12 B:LEU971 4.6 54.7 1.0 C05 A:T141201 4.6 90.2 1.0 HZ3 B:TRP877 4.7 35.8 1.0 HB2 B:LEU971 4.7 55.2 1.0 HG B:SER966 4.7 55.5 1.0 HD22 A:LEU860 4.8 61.2 1.0 HB3 B:LEU970 4.8 46.6 1.0 F15 A:T141201 4.9 101.2 1.0 HD22 B:LEU873 4.9 58.6 1.0 HD21 B:LEU974 4.9 57.1 1.0 HB2 B:LEU970 4.9 46.9 1.0 CD1 A:LEU860 4.9 62.7 1.0 C06 A:T141201 4.9 89.8 1.0 H071 A:T141201 5.0 100.0 1.0 HD11 B:LEU971 5.0 53.9 1.0

Fluorine binding site 2 out of 24 in the Cryo-Em Structure of the Mouse TRPM8 Channel in Complex with the Antagonist Tc-I 2014


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Cryo-Em Structure of the Mouse TRPM8 Channel in Complex with the Antagonist Tc-I 2014 within 5.0Å range: probe atom residue distance (Å) B Occ A:F1201 b:102.2 occ:1.00 F13 A:T141201 0.0 102.2 1.0 C12 A:T141201 1.3 96.9 1.0 F14 A:T141201 2.2 99.1 1.0 F15 A:T141201 2.2 101.2 1.0 C11 A:T141201 2.3 92.5 1.0 HAV1 A:Y011205 2.7 83.8 1.0 C16 A:T141201 3.1 89.2 1.0 H171 A:T141201 3.2 100.7 1.0 HAM1 A:Y011205 3.2 83.2 1.0 C10 A:T141201 3.3 97.9 1.0 N17 A:T141201 3.4 94.4 1.0 H101 A:T141201 3.5 100.4 1.0 CAV A:Y011205 3.6 82.9 1.0 HAV2 A:Y011205 3.8 83.3 1.0 HH2 A:TRP798 3.9 99.4 1.0 OAW A:Y011205 4.0 83.2 1.0 HAD1 A:Y011205 4.0 86.3 1.0 CAM A:Y011205 4.1 82.9 1.0 CAY A:Y011205 4.2 85.1 1.0 C30 A:T141201 4.3 87.3 1.0 CBC A:Y011205 4.4 85.0 1.0 HAD3 A:Y011205 4.4 84.7 1.0 HD13 A:ILE844 4.5 65.0 1.0 OAH A:Y011205 4.5 92.5 1.0 HAR1 A:Y011205 4.5 84.2 1.0 HD23 A:LEU860 4.5 62.9 1.0 C09 A:T141201 4.5 95.7 1.0 HG21 A:ILE844 4.5 64.2 1.0 HD12 A:ILE844 4.6 65.5 1.0 CAZ A:Y011205 4.6 83.2 1.0 C18 A:T141201 4.6 89.3 1.0 HZ2 B:TRP877 4.7 37.1 1.0 CAD A:Y011205 4.7 91.0 1.0 CH2 A:TRP798 4.7 97.5 1.0 CAX A:Y011205 4.8 91.5 1.0 HAM2 A:Y011205 4.8 83.5 1.0 HZ2 A:TRP798 4.8 98.4 1.0 HE1 B:TRP877 4.9 36.2 1.0 C31 A:T141201 5.0 92.8 1.0 OAG A:Y011205 5.0 89.1 1.0 CD1 A:ILE844 5.0 66.8 1.0

Fluorine binding site 3 out of 24 in the Cryo-Em Structure of the Mouse TRPM8 Channel in Complex with the Antagonist Tc-I 2014


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Cryo-Em Structure of the Mouse TRPM8 Channel in Complex with the Antagonist Tc-I 2014 within 5.0Å range: probe atom residue distance (Å) B Occ A:F1201 b:99.1 occ:1.00 F14 A:T141201 0.0 99.1 1.0 C12 A:T141201 1.3 96.9 1.0 F13 A:T141201 2.2 102.2 1.0 F15 A:T141201 2.2 101.2 1.0 C11 A:T141201 2.3 92.5 1.0 H171 A:T141201 2.6 100.7 1.0 HD13 A:ILE844 2.7 65.0 1.0 C16 A:T141201 2.8 89.2 1.0 HE1 B:TRP877 2.9 36.2 1.0 N17 A:T141201 3.0 94.4 1.0 HZ2 B:TRP877 3.0 37.1 1.0 HD12 A:ILE844 3.2 65.5 1.0 CD1 A:ILE844 3.3 66.8 1.0 C10 A:T141201 3.5 97.9 1.0 HG21 A:ILE844 3.6 64.2 1.0 NE1 B:TRP877 3.6 37.1 1.0 HD11 A:ILE844 3.7 64.5 1.0 HD22 B:LEU873 3.8 58.6 1.0 CZ2 B:TRP877 3.8 40.5 1.0 H101 A:T141201 3.9 100.4 1.0 CE2 B:TRP877 4.1 32.2 1.0 C30 A:T141201 4.2 87.3 1.0 C18 A:T141201 4.2 89.3 1.0 HAV1 A:Y011205 4.4 83.8 1.0 HD23 A:LEU860 4.4 62.9 1.0 HD22 A:LEU841 4.5 63.9 1.0 CG2 A:ILE844 4.5 58.7 1.0 HD21 B:LEU873 4.5 57.6 1.0 CD2 B:LEU873 4.6 54.4 1.0 CG1 A:ILE844 4.6 64.2 1.0 C09 A:T141201 4.7 95.7 1.0 HAD1 A:Y011205 4.7 86.3 1.0 HB A:ILE844 4.7 64.0 1.0 HH2 A:TRP798 4.7 99.4 1.0 HG22 A:ILE844 4.8 64.1 1.0 HG12 A:ILE844 4.9 65.2 1.0 CB A:ILE844 4.9 57.5 1.0 N29 A:T141201 4.9 87.0 1.0 HD23 B:LEU873 4.9 58.6 1.0 CD1 B:TRP877 4.9 35.0 1.0 N20 A:T141201 4.9 97.3 1.0 C31 A:T141201 4.9 92.8 1.0 HAM1 A:Y011205 5.0 83.2 1.0

Fluorine binding site 4 out of 24 in the Cryo-Em Structure of the Mouse TRPM8 Channel in Complex with the Antagonist Tc-I 2014


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Cryo-Em Structure of the Mouse TRPM8 Channel in Complex with the Antagonist Tc-I 2014 within 5.0Å range: probe atom residue distance (Å) B Occ A:F1201 b:101.2 occ:1.00 F15 A:T141201 0.0 101.2 1.0 C12 A:T141201 1.3 96.9 1.0 F14 A:T141201 2.2 99.1 1.0 F13 A:T141201 2.2 102.2 1.0 C11 A:T141201 2.3 92.5 1.0 H101 A:T141201 2.4 100.4 1.0 HD23 A:LEU860 2.5 62.9 1.0 C10 A:T141201 2.7 97.9 1.0 CD2 A:LEU860 3.4 49.5 1.0 HAM1 A:Y011205 3.5 83.2 1.0 HG21 A:ILE844 3.5 64.2 1.0 HD22 A:LEU860 3.6 61.2 1.0 C16 A:T141201 3.6 89.2 1.0 HD21 A:LEU860 3.7 61.5 1.0 HD13 A:ILE844 3.9 65.0 1.0 HZ2 B:TRP877 4.0 37.1 1.0 C09 A:T141201 4.1 95.7 1.0 H171 A:T141201 4.3 100.7 1.0 HD22 B:LEU873 4.3 58.6 1.0 HB3 A:LEU860 4.4 62.8 1.0 CG2 A:ILE844 4.4 58.7 1.0 N17 A:T141201 4.4 94.4 1.0 HG22 A:ILE844 4.4 64.1 1.0 HD21 B:LEU873 4.5 57.6 1.0 OAH A:Y011205 4.5 92.5 1.0 CG A:LEU860 4.5 49.6 1.0 CAM A:Y011205 4.6 82.9 1.0 HB2 A:LEU860 4.7 62.8 1.0 HD12 A:ILE844 4.7 65.5 1.0 HG A:LEU860 4.7 62.7 1.0 CD1 A:ILE844 4.7 66.8 1.0 HG23 A:ILE857 4.7 53.0 1.0 C30 A:T141201 4.7 87.3 1.0 HAV1 A:Y011205 4.7 83.8 1.0 CB A:LEU860 4.8 56.4 1.0 HH2 A:TRP798 4.8 99.4 1.0 F01 A:T141201 4.9 101.9 1.0 CD2 B:LEU873 4.9 54.4 1.0 HG23 A:ILE844 4.9 64.2 1.0 HAM2 A:Y011205 4.9 83.5 1.0 HE1 B:TRP877 4.9 36.2 1.0 CZ2 B:TRP877 4.9 40.5 1.0 C31 A:T141201 5.0 92.8 1.0

Fluorine binding site 5 out of 24 in the Cryo-Em Structure of the Mouse TRPM8 Channel in Complex with the Antagonist Tc-I 2014


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Cryo-Em Structure of the Mouse TRPM8 Channel in Complex with the Antagonist Tc-I 2014 within 5.0Å range: probe atom residue distance (Å) B Occ A:F1201 b:98.1 occ:1.00 F32 A:T141201 0.0 98.1 1.0 C02 A:T141201 1.3 91.9 1.0 F33 A:T141201 2.2 95.1 1.0 F01 A:T141201 2.2 101.9 1.0 C03 A:T141201 2.4 91.9 1.0 HH2 B:TRP877 2.6 36.9 1.0 H311 A:T141201 2.7 100.5 1.0 HB2 B:LEU970 2.9 46.9 1.0 C31 A:T141201 2.9 92.8 1.0 C08 A:T141201 3.0 94.8 1.0 C09 A:T141201 3.1 95.7 1.0 HB3 B:LEU970 3.1 46.6 1.0 HG B:SER966 3.2 55.5 1.0 C04 A:T141201 3.4 91.0 1.0 CH2 B:TRP877 3.4 42.8 1.0 CB B:LEU970 3.4 42.1 1.0 HD12 B:LEU970 3.5 45.5 1.0 H041 A:T141201 3.6 99.0 1.0 HD13 B:LEU970 3.6 45.7 1.0 OG B:SER966 3.6 65.5 1.0 C30 A:T141201 3.9 87.3 1.0 CD1 B:LEU970 4.0 32.0 1.0 HB2 B:LEU971 4.0 55.2 1.0 HZ3 B:TRP877 4.0 35.8 1.0 H B:LEU971 4.1 53.0 1.0 C10 A:T141201 4.1 97.9 1.0 HA B:LEU971 4.1 55.9 1.0 N B:LEU971 4.1 40.0 1.0 O B:SER966 4.1 55.0 1.0 CZ3 B:TRP877 4.2 32.3 1.0 HA B:SER966 4.2 52.9 1.0 HD13 B:LEU971 4.2 56.0 1.0 HZ2 B:TRP877 4.2 37.1 1.0 CZ2 B:TRP877 4.3 40.5 1.0 C07 A:T141201 4.3 91.8 1.0 CG B:LEU970 4.3 38.9 1.0 C B:LEU970 4.4 44.5 1.0 CA B:LEU970 4.5 32.7 1.0 CA B:LEU971 4.5 45.6 1.0 C05 A:T141201 4.6 90.2 1.0 H101 A:T141201 4.7 100.4 1.0 C16 A:T141201 4.7 89.2 1.0 CB B:LEU971 4.7 48.5 1.0 N29 A:T141201 4.7 87.0 1.0 CA B:SER966 4.8 41.4 1.0 CB B:SER966 4.8 43.3 1.0 C B:SER966 4.8 42.8 1.0 C11 A:T141201 4.8 92.5 1.0 HD11 B:LEU970 4.9 44.3 1.0 HG B:LEU970 4.9 46.8 1.0 HD22 B:LEU974 4.9 56.6 1.0 O B:LEU970 4.9 61.7 1.0 C06 A:T141201 4.9 89.8 1.0 HD13 B:LEU873 5.0 59.0 1.0

Fluorine binding site 6 out of 24 in the Cryo-Em Structure of the Mouse TRPM8 Channel in Complex with the Antagonist Tc-I 2014


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Cryo-Em Structure of the Mouse TRPM8 Channel in Complex with the Antagonist Tc-I 2014 within 5.0Å range: probe atom residue distance (Å) B Occ A:F1201 b:95.1 occ:1.00 F33 A:T141201 0.0 95.1 1.0 C02 A:T141201 1.3 91.9 1.0 F01 A:T141201 2.2 101.9 1.0 F32 A:T141201 2.2 98.1 1.0 H041 A:T141201 2.3 99.0 1.0 C03 A:T141201 2.3 91.9 1.0 C04 A:T141201 2.7 91.0 1.0 HD22 B:LEU974 2.8 56.6 1.0 HA B:LEU971 2.9 55.9 1.0 HB3 B:LEU970 3.3 46.6 1.0 HD13 B:LEU971 3.5 56.0 1.0 HB2 B:LEU974 3.5 54.5 1.0 HD23 B:LEU974 3.6 57.2 1.0 C08 A:T141201 3.6 94.8 1.0 CD2 B:LEU974 3.6 60.7 1.0 CA B:LEU971 3.7 45.6 1.0 HB2 B:LEU970 3.7 46.9 1.0 HH2 B:TRP877 3.7 36.9 1.0 C B:LEU970 3.7 44.5 1.0 N B:LEU971 3.7 40.0 1.0 O B:LEU970 3.8 61.7 1.0 HD12 B:LEU971 3.9 54.7 1.0 CB B:LEU970 3.9 42.1 1.0 HB3 B:LEU974 4.0 54.8 1.0 HB2 B:LEU971 4.0 55.2 1.0 C05 A:T141201 4.0 90.2 1.0 CD1 B:LEU971 4.1 48.3 1.0 CB B:LEU974 4.1 43.0 1.0 H B:LEU971 4.2 53.0 1.0 C09 A:T141201 4.3 95.7 1.0 HD21 B:LEU974 4.3 57.1 1.0 CB B:LEU971 4.4 48.5 1.0 HG A:LEU860 4.5 62.7 1.0 CA B:LEU970 4.5 32.7 1.0 CG B:LEU974 4.5 56.3 1.0 HD13 B:LEU873 4.6 59.0 1.0 H311 A:T141201 4.6 100.5 1.0 CH2 B:TRP877 4.6 42.8 1.0 H051 A:T141201 4.7 97.5 1.0 HD13 B:LEU974 4.7 55.8 1.0 HD21 A:LEU860 4.7 61.5 1.0 C31 A:T141201 4.7 92.8 1.0 C07 A:T141201 4.7 91.8 1.0 HD13 B:LEU970 4.8 45.7 1.0 HD11 B:LEU971 4.9 53.9 1.0 HA B:LEU970 4.9 46.2 1.0 C06 A:T141201 4.9 89.8 1.0 C B:LEU971 4.9 53.7 1.0 CG B:LEU971 4.9 52.5 1.0 HE2 A:PHE979 4.9 40.5 1.0 H B:LEU974 4.9 54.0 1.0

Fluorine binding site 7 out of 24 in the Cryo-Em Structure of the Mouse TRPM8 Channel in Complex with the Antagonist Tc-I 2014


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 7 of Cryo-Em Structure of the Mouse TRPM8 Channel in Complex with the Antagonist Tc-I 2014 within 5.0Å range: probe atom residue distance (Å) B Occ B:F1201 b:101.9 occ:1.00 F01 B:T141201 0.0 101.9 1.0 C02 B:T141201 1.3 91.9 1.0 F33 B:T141201 2.2 95.1 1.0 F32 B:T141201 2.2 98.1 1.0 C03 B:T141201 2.4 91.9 1.0 HH2 C:TRP877 2.6 36.9 1.0 C09 B:T141201 2.9 95.7 1.0 C08 B:T141201 3.0 94.8 1.0 C10 B:T141201 3.2 97.9 1.0 HD21 B:LEU860 3.3 61.5 1.0 HD13 C:LEU873 3.3 59.0 1.0 CH2 C:TRP877 3.4 42.8 1.0 H101 B:T141201 3.4 100.4 1.0 C04 B:T141201 3.4 91.0 1.0 HZ2 C:TRP877 3.5 37.1 1.0 C31 B:T141201 3.6 92.8 1.0 HD13 C:LEU971 3.6 56.0 1.0 HG B:LEU860 3.7 62.7 1.0 H041 B:T141201 3.7 99.0 1.0 CZ2 C:TRP877 3.8 40.5 1.0 HD23 B:LEU860 3.9 62.9 1.0 HD22 C:LEU974 3.9 56.6 1.0 CD2 B:LEU860 3.9 49.5 1.0 H311 B:T141201 3.9 100.5 1.0 HD11 C:LEU873 4.0 58.5 1.0 CD1 C:LEU873 4.0 57.9 1.0 C11 B:T141201 4.1 92.5 1.0 C07 B:T141201 4.3 91.8 1.0 C30 B:T141201 4.3 87.3 1.0 CG B:LEU860 4.3 49.6 1.0 HD12 C:LEU873 4.4 57.9 1.0 HD23 C:LEU974 4.4 57.2 1.0 C16 B:T141201 4.5 89.2 1.0 HA C:LEU971 4.5 55.9 1.0 CD1 C:LEU971 4.5 48.3 1.0 CZ3 C:TRP877 4.5 32.3 1.0 HD11 B:LEU860 4.6 63.2 1.0 CD2 C:LEU974 4.6 60.7 1.0 HD12 C:LEU971 4.6 54.7 1.0 C05 B:T141201 4.6 90.2 1.0 HZ3 C:TRP877 4.7 35.8 1.0 HB2 C:LEU971 4.7 55.2 1.0 HG C:SER966 4.7 55.5 1.0 HD22 B:LEU860 4.8 61.2 1.0 HB3 C:LEU970 4.8 46.6 1.0 F15 B:T141201 4.9 101.2 1.0 HD22 C:LEU873 4.9 58.6 1.0 HD21 C:LEU974 4.9 57.1 1.0 HB2 C:LEU970 4.9 46.9 1.0 CD1 B:LEU860 4.9 62.7 1.0 C06 B:T141201 4.9 89.8 1.0 H071 B:T141201 5.0 100.0 1.0 HD11 C:LEU971 5.0 53.9 1.0

Fluorine binding site 8 out of 24 in the Cryo-Em Structure of the Mouse TRPM8 Channel in Complex with the Antagonist Tc-I 2014


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 8 of Cryo-Em Structure of the Mouse TRPM8 Channel in Complex with the Antagonist Tc-I 2014 within 5.0Å range: probe atom residue distance (Å) B Occ B:F1201 b:102.2 occ:1.00 F13 B:T141201 0.0 102.2 1.0 C12 B:T141201 1.3 96.9 1.0 F14 B:T141201 2.2 99.1 1.0 F15 B:T141201 2.2 101.2 1.0 C11 B:T141201 2.3 92.5 1.0 HAV1 B:Y011205 2.7 83.8 1.0 C16 B:T141201 3.1 89.2 1.0 H171 B:T141201 3.2 100.7 1.0 HAM1 B:Y011205 3.2 83.2 1.0 C10 B:T141201 3.3 97.9 1.0 N17 B:T141201 3.4 94.4 1.0 H101 B:T141201 3.5 100.4 1.0 CAV B:Y011205 3.6 82.9 1.0 HAV2 B:Y011205 3.8 83.3 1.0 HH2 B:TRP798 3.9 99.4 1.0 OAW B:Y011205 4.0 83.2 1.0 HAD1 B:Y011205 4.0 86.3 1.0 CAM B:Y011205 4.1 82.9 1.0 CAY B:Y011205 4.2 85.1 1.0 C30 B:T141201 4.3 87.3 1.0 CBC B:Y011205 4.4 85.0 1.0 HAD3 B:Y011205 4.4 84.7 1.0 HD13 B:ILE844 4.5 65.0 1.0 OAH B:Y011205 4.5 92.5 1.0 HAR1 B:Y011205 4.5 84.2 1.0 HD23 B:LEU860 4.5 62.9 1.0 C09 B:T141201 4.5 95.7 1.0 HG21 B:ILE844 4.5 64.2 1.0 HD12 B:ILE844 4.6 65.5 1.0 CAZ B:Y011205 4.6 83.2 1.0 C18 B:T141201 4.6 89.3 1.0 HZ2 C:TRP877 4.7 37.1 1.0 CAD B:Y011205 4.7 91.0 1.0 CH2 B:TRP798 4.7 97.5 1.0 CAX B:Y011205 4.8 91.5 1.0 HAM2 B:Y011205 4.8 83.5 1.0 HZ2 B:TRP798 4.8 98.4 1.0 HE1 C:TRP877 4.9 36.2 1.0 C31 B:T141201 5.0 92.8 1.0 OAG B:Y011205 5.0 89.1 1.0 CD1 B:ILE844 5.0 66.8 1.0

Fluorine binding site 9 out of 24 in the Cryo-Em Structure of the Mouse TRPM8 Channel in Complex with the Antagonist Tc-I 2014


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 9 of Cryo-Em Structure of the Mouse TRPM8 Channel in Complex with the Antagonist Tc-I 2014 within 5.0Å range: probe atom residue distance (Å) B Occ B:F1201 b:99.1 occ:1.00 F14 B:T141201 0.0 99.1 1.0 C12 B:T141201 1.3 96.9 1.0 F13 B:T141201 2.2 102.2 1.0 F15 B:T141201 2.2 101.2 1.0 C11 B:T141201 2.3 92.5 1.0 H171 B:T141201 2.6 100.7 1.0 HD13 B:ILE844 2.7 65.0 1.0 C16 B:T141201 2.8 89.2 1.0 HE1 C:TRP877 2.9 36.2 1.0 N17 B:T141201 3.0 94.4 1.0 HZ2 C:TRP877 3.0 37.1 1.0 HD12 B:ILE844 3.2 65.5 1.0 CD1 B:ILE844 3.3 66.8 1.0 C10 B:T141201 3.5 97.9 1.0 HG21 B:ILE844 3.6 64.2 1.0 NE1 C:TRP877 3.6 37.1 1.0 HD11 B:ILE844 3.7 64.5 1.0 HD22 C:LEU873 3.8 58.6 1.0 CZ2 C:TRP877 3.8 40.5 1.0 H101 B:T141201 3.9 100.4 1.0 CE2 C:TRP877 4.1 32.2 1.0 C30 B:T141201 4.2 87.3 1.0 C18 B:T141201 4.2 89.3 1.0 HAV1 B:Y011205 4.4 83.8 1.0 HD23 B:LEU860 4.4 62.9 1.0 HD22 B:LEU841 4.5 63.9 1.0 CG2 B:ILE844 4.5 58.7 1.0 HD21 C:LEU873 4.5 57.6 1.0 CD2 C:LEU873 4.5 54.4 1.0 CG1 B:ILE844 4.6 64.2 1.0 C09 B:T141201 4.7 95.7 1.0 HAD1 B:Y011205 4.7 86.3 1.0 HB B:ILE844 4.7 64.0 1.0 HH2 B:TRP798 4.7 99.4 1.0 HG22 B:ILE844 4.8 64.1 1.0 HG12 B:ILE844 4.9 65.2 1.0 CB B:ILE844 4.9 57.5 1.0 HD23 C:LEU873 4.9 58.6 1.0 N29 B:T141201 4.9 87.0 1.0 CD1 C:TRP877 4.9 35.0 1.0 N20 B:T141201 4.9 97.3 1.0 C31 B:T141201 4.9 92.8 1.0 HAM1 B:Y011205 5.0 83.2 1.0

Fluorine binding site 10 out of 24 in the Cryo-Em Structure of the Mouse TRPM8 Channel in Complex with the Antagonist Tc-I 2014


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 10 of Cryo-Em Structure of the Mouse TRPM8 Channel in Complex with the Antagonist Tc-I 2014 within 5.0Å range: probe atom residue distance (Å) B Occ B:F1201 b:101.2 occ:1.00 F15 B:T141201 0.0 101.2 1.0 C12 B:T141201 1.3 96.9 1.0 F14 B:T141201 2.2 99.1 1.0 F13 B:T141201 2.2 102.2 1.0 C11 B:T141201 2.3 92.5 1.0 H101 B:T141201 2.4 100.4 1.0 HD23 B:LEU860 2.5 62.9 1.0 C10 B:T141201 2.7 97.9 1.0 CD2 B:LEU860 3.4 49.5 1.0 HAM1 B:Y011205 3.5 83.2 1.0 HG21 B:ILE844 3.5 64.2 1.0 HD22 B:LEU860 3.6 61.2 1.0 C16 B:T141201 3.6 89.2 1.0 HD21 B:LEU860 3.7 61.5 1.0 HD13 B:ILE844 3.9 65.0 1.0 HZ2 C:TRP877 4.0 37.1 1.0 C09 B:T141201 4.1 95.7 1.0 H171 B:T141201 4.3 100.7 1.0 HD22 C:LEU873 4.3 58.6 1.0 HB3 B:LEU860 4.4 62.8 1.0 CG2 B:ILE844 4.4 58.7 1.0 N17 B:T141201 4.4 94.4 1.0 HG22 B:ILE844 4.4 64.1 1.0 HD21 C:LEU873 4.5 57.6 1.0 OAH B:Y011205 4.5 92.5 1.0 CG B:LEU860 4.5 49.6 1.0 CAM B:Y011205 4.6 82.9 1.0 HB2 B:LEU860 4.7 62.8 1.0 HD12 B:ILE844 4.7 65.5 1.0 HG B:LEU860 4.7 62.7 1.0 CD1 B:ILE844 4.7 66.8 1.0 HG23 B:ILE857 4.7 53.0 1.0 C30 B:T141201 4.7 87.3 1.0 HAV1 B:Y011205 4.7 83.8 1.0 CB B:LEU860 4.8 56.4 1.0 HH2 B:TRP798 4.8 99.4 1.0 F01 B:T141201 4.9 101.9 1.0 CD2 C:LEU873 4.9 54.4 1.0 HG23 B:ILE844 4.9 64.2 1.0 HAM2 B:Y011205 4.9 83.5 1.0 HE1 C:TRP877 4.9 36.2 1.0 CZ2 C:TRP877 4.9 40.5 1.0 C31 B:T141201 5.0 92.8 1.0

Y.Yin, C.G.Park, F.Zhang, J.G Fedor, S.Feng, Y.Suo, W.Im, S.Y.Lee. Mechanisms of Sensory Adaptation and Inhibition of the Cold and Menthol Receptor TRPM8. Sci Adv V. 10 P2211 2024.
ISSN: ESSN 2375-2548
PubMed: 39093967
DOI: 10.1126/SCIADV.ADP2211