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Fluorine in PDB 9cmu: Room-Temperature X-Ray Structure of Sars-Cov-2 Main Protease Drug Resistant Mutant (L50F, E166V) in Complex with Ensitrelvir (Esv)Enzymatic activity of Room-Temperature X-Ray Structure of Sars-Cov-2 Main Protease Drug Resistant Mutant (L50F, E166V) in Complex with Ensitrelvir (Esv)
All present enzymatic activity of Room-Temperature X-Ray Structure of Sars-Cov-2 Main Protease Drug Resistant Mutant (L50F, E166V) in Complex with Ensitrelvir (Esv):
3.4.22.69; Protein crystallography data
The structure of Room-Temperature X-Ray Structure of Sars-Cov-2 Main Protease Drug Resistant Mutant (L50F, E166V) in Complex with Ensitrelvir (Esv), PDB code: 9cmu
was solved by
A.Kovalevsky,
L.Coates,
O.Gerlits,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 9cmu:
The structure of Room-Temperature X-Ray Structure of Sars-Cov-2 Main Protease Drug Resistant Mutant (L50F, E166V) in Complex with Ensitrelvir (Esv) also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Room-Temperature X-Ray Structure of Sars-Cov-2 Main Protease Drug Resistant Mutant (L50F, E166V) in Complex with Ensitrelvir (Esv)
(pdb code 9cmu). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Room-Temperature X-Ray Structure of Sars-Cov-2 Main Protease Drug Resistant Mutant (L50F, E166V) in Complex with Ensitrelvir (Esv), PDB code: 9cmu: Jump to Fluorine binding site number: 1; 2; 3; Fluorine binding site 1 out of 3 in 9cmuGo back to Fluorine Binding Sites List in 9cmu
Fluorine binding site 1 out
of 3 in the Room-Temperature X-Ray Structure of Sars-Cov-2 Main Protease Drug Resistant Mutant (L50F, E166V) in Complex with Ensitrelvir (Esv)
Mono view Stereo pair view
Fluorine binding site 2 out of 3 in 9cmuGo back to Fluorine Binding Sites List in 9cmu
Fluorine binding site 2 out
of 3 in the Room-Temperature X-Ray Structure of Sars-Cov-2 Main Protease Drug Resistant Mutant (L50F, E166V) in Complex with Ensitrelvir (Esv)
Mono view Stereo pair view
Fluorine binding site 3 out of 3 in 9cmuGo back to Fluorine Binding Sites List in 9cmu
Fluorine binding site 3 out
of 3 in the Room-Temperature X-Ray Structure of Sars-Cov-2 Main Protease Drug Resistant Mutant (L50F, E166V) in Complex with Ensitrelvir (Esv)
Mono view Stereo pair view
Reference:
A.Kovalevsky,
A.Aniana,
R.Ghirlando,
L.Coates,
V.N.Drago,
L.Wear,
O.Gerlits,
N.T.Nashed,
J.M.Louis.
Effects of Sars-Cov-2 Main Protease Mutations at Positions L50, E166, and L167 Rendering Resistance to Covalent and Noncovalent Inhibitors. J.Med.Chem. 2024.
Page generated: Thu Oct 31 20:07:49 2024
ISSN: ISSN 0022-2623 PubMed: 39370853 DOI: 10.1021/ACS.JMEDCHEM.4C01781 |
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