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Atomistry » Fluorine » PDB 7ugj-7v3s » 7uyt » |
Fluorine in PDB 7uyt: Crystal Structure of TYK2 Kinase Domain in Complex with Compound 25Enzymatic activity of Crystal Structure of TYK2 Kinase Domain in Complex with Compound 25
All present enzymatic activity of Crystal Structure of TYK2 Kinase Domain in Complex with Compound 25:
2.7.10.2; Protein crystallography data
The structure of Crystal Structure of TYK2 Kinase Domain in Complex with Compound 25, PDB code: 7uyt
was solved by
A.V.Toms,
S.Leit,
J.R.Greenwood,
S.Mondal,
S.Carriero,
M.Dahlgren,
G.C.Harriman,
J.J.Kennedy-Smith,
R.Kapeller,
J.P.Lawson,
D.L.Romero,
M.Shelley,
R.T.Wester,
W.Westlin,
J.J.Mc Elwee,
W.Miao,
S.D.Edmondson,
C.E.Massee,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7uyt:
The structure of Crystal Structure of TYK2 Kinase Domain in Complex with Compound 25 also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of TYK2 Kinase Domain in Complex with Compound 25
(pdb code 7uyt). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of TYK2 Kinase Domain in Complex with Compound 25, PDB code: 7uyt: Fluorine binding site 1 out of 1 in 7uytGo back to![]() ![]()
Fluorine binding site 1 out
of 1 in the Crystal Structure of TYK2 Kinase Domain in Complex with Compound 25
![]() Mono view ![]() Stereo pair view
Reference:
S.Leit,
J.R.Greenwood,
S.Mondal,
S.Carriero,
M.Dahlgren,
G.C.Harriman,
J.J.Kennedy-Smith,
R.Kapeller,
J.P.Lawson,
D.L.Romero,
A.V.Toms,
M.Shelley,
R.T.Wester,
W.Westlin,
J.J.Mcelwee,
W.Miao,
S.D.Edmondson,
C.E.Masse.
Potent and Selective TYK2-JH1 Inhibitors Highly Efficacious in Rodent Model of Psoriasis. Bioorg.Med.Chem.Lett. V. 73 28891 2022.
Page generated: Wed Jul 16 01:07:54 2025
ISSN: ESSN 1464-3405 PubMed: 35842205 DOI: 10.1016/J.BMCL.2022.128891 |
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