Fluorine in PDB 9gl2: Befiradol-Bound Serotonin 5-HT1A Receptor - Gs Protein Complex

The structure of Befiradol-Bound Serotonin 5-HT1A Receptor - Gs Protein Complex also contains other interesting chemical elements:

Chlorine

(Cl)

1 atom

The binding sites of Fluorine atom in the Befiradol-Bound Serotonin 5-HT1A Receptor - Gs Protein Complex (pdb code 9gl2). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Befiradol-Bound Serotonin 5-HT1A Receptor - Gs Protein Complex, PDB code: 9gl2:
Jump to Fluorine binding site number: 1; 2;

Fluorine binding site 1 out of 2 in the Befiradol-Bound Serotonin 5-HT1A Receptor - Gs Protein Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Befiradol-Bound Serotonin 5-HT1A Receptor - Gs Protein Complex within 5.0Å range: probe atom residue distance (Å) B Occ R:F503 b:7.6 occ:1.00 F01 R:ZKV503 0.0 7.6 1.0 C18 R:ZKV503 1.3 7.6 1.0 C19 R:ZKV503 2.3 7.6 1.0 C17 R:ZKV503 2.3 7.6 1.0 CL01 R:ZKV503 2.9 7.6 1.0 C16 R:ZKV503 3.6 7.6 1.0 C20 R:ZKV503 3.6 7.6 1.0 CB R:TYR96 3.6 8.3 1.0 CZ3 R:TRP102 3.7 12.2 1.0 CA R:ALA93 3.7 7.5 1.0 CH2 R:TRP102 4.0 12.2 1.0 N R:ALA93 4.1 7.5 1.0 C15 R:ZKV503 4.1 7.6 1.0 CG R:TYR96 4.1 8.3 1.0 O R:MET92 4.2 10.0 1.0 CD2 R:TYR96 4.2 8.3 1.0 C R:MET92 4.3 10.0 1.0 CB R:ALA93 4.3 7.5 1.0 SG R:CYS187 4.3 10.8 1.0 CE3 R:TRP102 4.4 12.2 1.0 C R:ALA93 4.7 7.5 1.0 O R:ALA93 4.8 7.5 1.0 CA R:TYR96 5.0 8.3 1.0

Fluorine binding site 2 out of 2 in the Befiradol-Bound Serotonin 5-HT1A Receptor - Gs Protein Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Befiradol-Bound Serotonin 5-HT1A Receptor - Gs Protein Complex within 5.0Å range: probe atom residue distance (Å) B Occ R:F503 b:7.6 occ:1.00 F02 R:ZKV503 0.0 7.6 1.0 C09 R:ZKV503 1.3 7.6 1.0 C10 R:ZKV503 2.3 7.6 1.0 C13 R:ZKV503 2.3 7.6 1.0 C08 R:ZKV503 2.4 7.6 1.0 C12 R:ZKV503 2.9 7.6 1.0 C11 R:ZKV503 2.9 7.6 1.0 OD1 R:ASN386 3.0 7.8 1.0 CE1 R:PHE361 3.2 6.3 1.0 N02 R:ZKV503 3.3 7.6 1.0 N03 R:ZKV503 3.4 7.6 1.0 CZ R:PHE361 3.4 6.3 1.0 CD1 R:PHE361 3.8 6.3 1.0 C07 R:ZKV503 4.0 7.6 1.0 CG R:ASN386 4.1 7.8 1.0 CE2 R:PHE361 4.3 6.3 1.0 CB R:ASN386 4.6 7.8 1.0 CG R:PHE361 4.6 6.3 1.0 C14 R:ZKV503 4.7 7.6 1.0 CD2 R:PHE361 4.8 6.3 1.0 CA R:ASN386 4.9 7.8 1.0 OH R:TYR390 4.9 7.3 1.0 C04 R:ZKV503 5.0 7.6 1.0

A.Ullrich, J.Schneider, J.M.Braz, E.Neu, N.Staffen, M.Stanek, J.Blahova, T.Hove, T.Albert, A.Allikalt, S.Lober, K.Bhardwaj, S.Rodriguez-Rosado, E.Fink, T.Rasmussen, H.Hubner, A.Inoue, B.K.Shoichet, A.I.Basbaum, B.Bottcher, D.Weikert, P.Gmeiner. Discovery of A Functionally Selective Serotonin Receptor (5-Ht 1A R) Agonist For the Treatment of Pain. Sci Adv V. 11 V9267 2025.
ISSN: ESSN 2375-2548
PubMed: 40531992
DOI: 10.1126/SCIADV.ADV9267