Fluorine in PDB 8wpm: Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145

The structure of Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145 also contains other interesting chemical elements:

Chlorine	(Cl)	4 atoms
Calcium	(Ca)	3 atoms
Zinc	(Zn)	4 atoms

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 12;

Binding sites:

The binding sites of Fluorine atom in the Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145 (pdb code 8wpm). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 12 binding sites of Fluorine where determined in the Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145, PDB code: 8wpm:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Fluorine binding site 1 out of 12 in the Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145 within 5.0Å range: probe atom residue distance (Å) B Occ A:F801 b:53.9 occ:1.00 F15 A:PJQ801 0.0 53.9 1.0 C14 A:PJQ801 1.4 49.8 1.0 F17 A:PJQ801 2.2 48.0 1.0 F16 A:PJQ801 2.2 60.7 1.0 O13 A:PJQ801 2.3 37.8 1.0 C12 A:PJQ801 2.8 37.6 1.0 CD2 A:PHE544 3.1 37.0 1.0 C11 A:PJQ801 3.1 45.0 1.0 CD2 A:LEU541 3.2 36.8 1.0 CE2 A:PHE544 3.3 34.9 1.0 CG A:PHE544 3.8 33.1 1.0 C18 A:PJQ801 3.9 37.6 1.0 CG A:LEU541 4.1 48.0 1.0 CZ A:PHE544 4.2 38.0 1.0 C10 A:PJQ801 4.3 40.9 1.0 CD1 A:LEU541 4.3 45.2 1.0 CB A:PHE544 4.4 34.5 1.0 CB A:LEU541 4.5 42.5 1.0 CD1 A:PHE544 4.6 36.8 1.0 CE1 A:PHE544 4.8 41.3 1.0 CD1 A:ILE598 4.8 37.8 1.0 CA A:LEU541 4.8 35.5 1.0 C08 A:PJQ801 4.9 42.9 1.0

Fluorine binding site 2 out of 12 in the Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145 within 5.0Å range: probe atom residue distance (Å) B Occ A:F801 b:60.7 occ:1.00 F16 A:PJQ801 0.0 60.7 1.0 C14 A:PJQ801 1.4 49.8 1.0 F17 A:PJQ801 2.2 48.0 1.0 F15 A:PJQ801 2.2 53.9 1.0 O13 A:PJQ801 2.3 37.8 1.0 C11 A:PJQ801 3.0 45.0 1.0 C12 A:PJQ801 3.0 37.6 1.0 CD2 A:LEU541 3.4 36.8 1.0 CG1 D:VAL606 3.4 11.3 1.0 CD1 A:LEU541 3.6 45.2 1.0 CG2 D:VAL606 4.1 24.1 1.0 CG A:LEU541 4.1 48.0 1.0 CG1 D:VAL610 4.2 34.1 1.0 CB D:VAL606 4.3 12.8 1.0 C10 A:PJQ801 4.3 40.9 1.0 C18 A:PJQ801 4.4 37.6 1.0 CB D:VAL610 4.6 40.3 1.0 CG2 D:VAL610 4.7 30.2 1.0

Fluorine binding site 3 out of 12 in the Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145 within 5.0Å range: probe atom residue distance (Å) B Occ A:F801 b:48.0 occ:1.00 F17 A:PJQ801 0.0 48.0 1.0 C14 A:PJQ801 1.4 49.8 1.0 F16 A:PJQ801 2.2 60.7 1.0 F15 A:PJQ801 2.2 53.9 1.0 O13 A:PJQ801 2.3 37.8 1.0 CD1 A:ILE598 3.2 37.8 1.0 C12 A:PJQ801 3.6 37.6 1.0 CG2 D:VAL610 3.9 30.2 1.0 CG2 D:VAL606 4.2 24.1 1.0 C11 A:PJQ801 4.3 45.0 1.0 CE2 A:PHE544 4.3 34.9 1.0 CG1 A:ILE598 4.5 38.7 1.0 CB D:VAL610 4.5 40.3 1.0 CG1 D:VAL610 4.5 34.1 1.0 C18 A:PJQ801 4.6 37.6 1.0 CD2 A:LEU541 4.6 36.8 1.0 CG1 D:VAL606 4.6 11.3 1.0 CD2 A:PHE544 4.6 37.0 1.0 CZ A:PHE544 4.7 38.0 1.0 CB A:ILE598 4.9 26.9 1.0 CB D:VAL606 4.9 12.8 1.0

Fluorine binding site 4 out of 12 in the Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145 within 5.0Å range: probe atom residue distance (Å) B Occ B:F1001 b:34.6 occ:1.00 F15 B:PJQ1001 0.0 34.6 1.0 C14 B:PJQ1001 1.4 38.5 1.0 F17 B:PJQ1001 2.2 42.6 1.0 F16 B:PJQ1001 2.2 43.4 1.0 O13 B:PJQ1001 2.3 44.4 1.0 C12 B:PJQ1001 2.8 36.0 1.0 CE2 B:TYR523 3.1 36.2 1.0 C18 B:PJQ1001 3.1 31.4 1.0 OH B:TYR523 3.3 31.7 1.0 CZ B:TYR523 3.4 41.4 1.0 CD1 B:PHE572 3.4 23.1 1.0 CD1 B:ILE575 3.5 23.1 1.0 CE1 B:PHE572 3.5 21.5 1.0 C11 B:PJQ1001 3.8 39.8 1.0 CD2 B:TYR523 4.0 36.5 1.0 C08 B:PJQ1001 4.3 37.1 1.0 CE1 B:TYR523 4.4 43.5 1.0 CG B:PHE572 4.7 24.9 1.0 CG2 A:VAL631 4.7 14.8 1.0 CG1 B:ILE575 4.7 13.6 1.0 C10 B:PJQ1001 4.8 38.8 1.0 CZ B:PHE572 4.8 21.6 1.0 CG B:TYR523 4.9 34.3 1.0 C09 B:PJQ1001 5.0 39.7 1.0

Fluorine binding site 5 out of 12 in the Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145 within 5.0Å range: probe atom residue distance (Å) B Occ B:F1001 b:43.4 occ:1.00 F16 B:PJQ1001 0.0 43.4 1.0 C14 B:PJQ1001 1.4 38.5 1.0 F17 B:PJQ1001 2.2 42.6 1.0 F15 B:PJQ1001 2.2 34.6 1.0 O13 B:PJQ1001 2.3 44.4 1.0 C12 B:PJQ1001 2.9 36.0 1.0 C11 B:PJQ1001 3.1 39.8 1.0 CE2 B:TYR523 3.1 36.2 1.0 CD2 B:TYR523 3.2 36.5 1.0 CD2 B:LEU520 3.5 34.2 1.0 CZ B:TYR523 3.7 41.4 1.0 CG B:TYR523 3.8 34.3 1.0 C18 B:PJQ1001 4.0 31.4 1.0 CD1 B:ILE575 4.2 23.1 1.0 CE1 B:TYR523 4.3 43.5 1.0 CD1 B:TYR523 4.3 31.2 1.0 C10 B:PJQ1001 4.3 38.8 1.0 OH B:TYR523 4.4 31.7 1.0 CG2 A:ILE635 4.5 32.3 1.0 CB B:TYR523 4.6 31.6 1.0 CG B:LEU520 4.7 46.3 1.0 CD1 B:LEU520 4.9 43.7 1.0 CG1 A:ILE635 4.9 29.3 1.0 C08 B:PJQ1001 5.0 37.1 1.0

Fluorine binding site 6 out of 12 in the Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145 within 5.0Å range: probe atom residue distance (Å) B Occ B:F1001 b:42.6 occ:1.00 F17 B:PJQ1001 0.0 42.6 1.0 C14 B:PJQ1001 1.4 38.5 1.0 F16 B:PJQ1001 2.2 43.4 1.0 F15 B:PJQ1001 2.2 34.6 1.0 O13 B:PJQ1001 2.2 44.4 1.0 CG1 A:ILE635 3.2 29.3 1.0 CG2 A:ILE635 3.5 32.3 1.0 C12 B:PJQ1001 3.5 36.0 1.0 CB A:ILE635 3.8 33.5 1.0 CG2 A:VAL631 3.9 14.8 1.0 CD1 A:ILE635 4.1 39.1 1.0 CD1 B:ILE575 4.1 23.1 1.0 CE1 B:PHE572 4.3 21.5 1.0 C11 B:PJQ1001 4.4 39.8 1.0 C18 B:PJQ1001 4.4 31.4 1.0 CZ B:PHE576 4.6 26.8 1.0 CB A:VAL631 4.7 13.7 1.0 CG1 A:VAL631 4.7 17.9 1.0 CE2 B:TYR523 4.8 36.2 1.0 CA A:VAL631 4.8 6.0 1.0 CD1 B:PHE572 4.8 23.1 1.0 CE1 B:PHE576 4.9 17.2 1.0 CD2 B:LEU520 5.0 34.2 1.0

Fluorine binding site 7 out of 12 in the Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 7 of Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145 within 5.0Å range: probe atom residue distance (Å) B Occ C:F1001 b:27.2 occ:1.00 F15 C:PJQ1001 0.0 27.2 1.0 C14 C:PJQ1001 1.4 34.8 1.0 F17 C:PJQ1001 2.2 47.7 1.0 F16 C:PJQ1001 2.2 36.0 1.0 O13 C:PJQ1001 2.3 38.5 1.0 C12 C:PJQ1001 2.8 32.1 1.0 CE2 C:TYR523 3.1 36.9 1.0 C18 C:PJQ1001 3.1 28.3 1.0 CE1 C:PHE572 3.3 23.1 1.0 CD1 C:PHE572 3.3 28.9 1.0 CD1 C:ILE575 3.3 16.5 1.0 CZ C:TYR523 3.4 40.9 1.0 OH C:TYR523 3.5 39.7 1.0 CD2 C:TYR523 3.8 44.4 1.0 C11 C:PJQ1001 3.9 35.2 1.0 C08 C:PJQ1001 4.3 34.3 1.0 CG2 B:VAL606 4.4 16.0 1.0 CE1 C:TYR523 4.5 41.7 1.0 CZ C:PHE572 4.6 21.8 1.0 CG C:PHE572 4.6 22.9 1.0 CG1 C:ILE575 4.7 14.2 1.0 CG C:TYR523 4.8 39.0 1.0 C10 C:PJQ1001 4.9 34.5 1.0

Fluorine binding site 8 out of 12 in the Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 8 of Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145 within 5.0Å range: probe atom residue distance (Å) B Occ C:F1001 b:36.0 occ:1.00 F16 C:PJQ1001 0.0 36.0 1.0 C14 C:PJQ1001 1.4 34.8 1.0 F17 C:PJQ1001 2.2 47.7 1.0 F15 C:PJQ1001 2.2 27.2 1.0 O13 C:PJQ1001 2.3 38.5 1.0 C12 C:PJQ1001 2.9 32.1 1.0 CD2 C:TYR523 3.1 44.4 1.0 CE2 C:TYR523 3.1 36.9 1.0 C11 C:PJQ1001 3.2 35.2 1.0 CG C:TYR523 3.7 39.0 1.0 CZ C:TYR523 3.8 40.9 1.0 CD2 C:LEU520 3.8 38.7 1.0 C18 C:PJQ1001 4.0 28.3 1.0 CD1 C:TYR523 4.3 32.2 1.0 CE1 C:TYR523 4.3 41.7 1.0 CD1 C:ILE575 4.3 16.5 1.0 C10 C:PJQ1001 4.4 34.5 1.0 CB C:TYR523 4.5 34.1 1.0 OH C:TYR523 4.5 39.7 1.0 CG2 B:VAL610 4.9 25.2 1.0 CG1 B:VAL610 4.9 25.9 1.0 C08 C:PJQ1001 5.0 34.3 1.0

Fluorine binding site 9 out of 12 in the Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 9 of Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145 within 5.0Å range: probe atom residue distance (Å) B Occ C:F1001 b:47.7 occ:1.00 F17 C:PJQ1001 0.0 47.7 1.0 C14 C:PJQ1001 1.4 34.8 1.0 F16 C:PJQ1001 2.2 36.0 1.0 F15 C:PJQ1001 2.2 27.2 1.0 O13 C:PJQ1001 2.2 38.5 1.0 CG2 B:VAL606 3.4 16.0 1.0 CG2 B:VAL610 3.4 25.2 1.0 C12 C:PJQ1001 3.6 32.1 1.0 CD1 C:ILE575 4.1 16.5 1.0 CB B:VAL610 4.1 26.9 1.0 CE1 C:PHE572 4.1 23.1 1.0 CG1 B:VAL606 4.2 13.0 1.0 CG1 B:VAL610 4.2 25.9 1.0 CB B:VAL606 4.3 10.9 1.0 C18 C:PJQ1001 4.4 28.3 1.0 C11 C:PJQ1001 4.4 35.2 1.0 CA B:VAL606 4.7 6.0 1.0 CE2 C:TYR523 4.8 36.9 1.0 CD1 C:PHE572 4.8 28.9 1.0 CZ C:PHE576 4.9 24.7 1.0

Fluorine binding site 10 out of 12 in the Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 10 of Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145 within 5.0Å range: probe atom residue distance (Å) B Occ D:F1001 b:27.8 occ:1.00 F15 D:PJQ1001 0.0 27.8 1.0 C14 D:PJQ1001 1.4 34.4 1.0 F17 D:PJQ1001 2.2 46.1 1.0 F16 D:PJQ1001 2.2 36.7 1.0 O13 D:PJQ1001 2.3 34.8 1.0 C12 D:PJQ1001 2.9 29.9 1.0 OH D:TYR523 3.0 46.4 1.0 CZ D:TYR523 3.1 48.4 1.0 CE2 D:TYR523 3.1 46.0 1.0 C18 D:PJQ1001 3.2 22.7 1.0 CD1 D:ILE575 3.4 13.1 1.0 CD1 D:PHE572 3.6 19.6 1.0 CE1 D:PHE572 3.6 18.4 1.0 CE1 D:TYR523 3.9 42.7 1.0 CD2 D:TYR523 3.9 45.3 1.0 C11 D:PJQ1001 3.9 40.1 1.0 C08 D:PJQ1001 4.4 30.1 1.0 CG2 C:VAL606 4.5 16.5 1.0 CD1 D:TYR523 4.6 32.8 1.0 CG D:TYR523 4.6 39.6 1.0 CG1 D:ILE575 4.7 11.0 1.0 CZ D:PHE576 4.8 28.2 1.0 CG D:PHE572 4.9 18.1 1.0 CZ D:PHE572 4.9 19.2 1.0 C10 D:PJQ1001 5.0 40.1 1.0

J.Won, H.Jeong, H.H.Lee. Structure of A Trp Channel To Be Published.