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Atomistry » Fluorine » PDB 461d-4azy » 4anq » |
Fluorine in PDB 4anq: Structure of G1269A Mutant Anaplastic Lymphoma Kinase in Complex with CrizotinibEnzymatic activity of Structure of G1269A Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib
All present enzymatic activity of Structure of G1269A Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib:
2.7.10.1; Protein crystallography data
The structure of Structure of G1269A Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib, PDB code: 4anq
was solved by
M.Mctigue,
Y.Deng,
W.Liu,
A.Brooun,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4anq:
The structure of Structure of G1269A Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Structure of G1269A Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib
(pdb code 4anq). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Structure of G1269A Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib, PDB code: 4anq: Fluorine binding site 1 out of 1 in 4anqGo back to![]() ![]()
Fluorine binding site 1 out
of 1 in the Structure of G1269A Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib
![]() Mono view ![]() Stereo pair view
Reference:
Q.Huang,
T.W.Johnson,
S.Bailey,
A.Brooun,
K.D.Bunker,
B.J.Burke,
M.R.Collins,
A.S.Cook,
J.J.Cui,
K.N.Dack,
J.G.Deal,
Y.Deng,
D.Dinh,
L.D.Engstrom,
M.He,
J.Hoffman,
R.L.Hoffman,
P.S.Johnson,
R.S.Kania,
H.Lam,
J.L.Lam,
P.T.Le,
Q.Li,
L.Lingardo,
W.Liu,
M.W.Lu,
M.Mctigue,
C.L.Palmer,
P.F.Richardson,
N.W.Sach,
H.Shen,
T.Smeal,
G.L.Smith,
A.E.Stewart,
S.Timofeevski,
K.Tsaparikos,
H.Wang,
H.Zhu,
J.Zhu,
H.Y.Zou,
M.P.Edwards.
Design of Potent and Selective Inhibitors to Overcome Clinical Anaplastic Lymphoma Kinase Mutations Resistant to Crizotinib. J.Med.Chem. V. 57 1170 2014.
Page generated: Thu Aug 1 00:01:32 2024
ISSN: ISSN 0022-2623 PubMed: 24432909 DOI: 10.1021/JM401805H |
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