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Fluorine in PDB 1hwl: Complex of the Catalytic Portion of Human Hmg-Coa Reductase with Rosuvastatin (Formally Known As ZD4522)
Enzymatic activity of Complex of the Catalytic Portion of Human Hmg-Coa Reductase with Rosuvastatin (Formally Known As ZD4522)
All present enzymatic activity of Complex of the Catalytic Portion of Human Hmg-Coa Reductase with Rosuvastatin (Formally Known As ZD4522):
1.1.1.34;
1.1.1.34;
Protein crystallography data
The structure of Complex of the Catalytic Portion of Human Hmg-Coa Reductase with Rosuvastatin (Formally Known As ZD4522), PDB code: 1hwl
was solved by
E.S.Istvan,
J.Deisenhofer,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 43.29 / 2.10 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 74.432, 172.512, 79.987, 90.00, 117.36, 90.00 |
| R / Rfree (%) | 21.9 / 23.9 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Complex of the Catalytic Portion of Human Hmg-Coa Reductase with Rosuvastatin (Formally Known As ZD4522)
(pdb code 1hwl). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Complex of the Catalytic Portion of Human Hmg-Coa Reductase with Rosuvastatin (Formally Known As ZD4522), PDB code: 1hwl:
Jump to Fluorine binding site number: 1; 2; 3; 4;
In total 4 binding sites of Fluorine where determined in the Complex of the Catalytic Portion of Human Hmg-Coa Reductase with Rosuvastatin (Formally Known As ZD4522), PDB code: 1hwl:
Jump to Fluorine binding site number: 1; 2; 3; 4;
Fluorine binding site 1 out of 4 in 1hwl
Go back to
Fluorine Binding Sites List in 1hwl
Fluorine binding site 1 out
of 4 in the Complex of the Catalytic Portion of Human Hmg-Coa Reductase with Rosuvastatin (Formally Known As ZD4522)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Complex of the Catalytic Portion of Human Hmg-Coa Reductase with Rosuvastatin (Formally Known As ZD4522) within 5.0Å range:
|
Fluorine binding site 2 out of 4 in 1hwl
Go back to
Fluorine Binding Sites List in 1hwl
Fluorine binding site 2 out
of 4 in the Complex of the Catalytic Portion of Human Hmg-Coa Reductase with Rosuvastatin (Formally Known As ZD4522)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Complex of the Catalytic Portion of Human Hmg-Coa Reductase with Rosuvastatin (Formally Known As ZD4522) within 5.0Å range:
|
Fluorine binding site 3 out of 4 in 1hwl
Go back to
Fluorine Binding Sites List in 1hwl
Fluorine binding site 3 out
of 4 in the Complex of the Catalytic Portion of Human Hmg-Coa Reductase with Rosuvastatin (Formally Known As ZD4522)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Complex of the Catalytic Portion of Human Hmg-Coa Reductase with Rosuvastatin (Formally Known As ZD4522) within 5.0Å range:
|
Fluorine binding site 4 out of 4 in 1hwl
Go back to
Fluorine Binding Sites List in 1hwl
Fluorine binding site 4 out
of 4 in the Complex of the Catalytic Portion of Human Hmg-Coa Reductase with Rosuvastatin (Formally Known As ZD4522)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Complex of the Catalytic Portion of Human Hmg-Coa Reductase with Rosuvastatin (Formally Known As ZD4522) within 5.0Å range:
|
Reference:
E.S.Istvan,
J.Deisenhofer.
Structural Mechanism For Statin Inhibition of Hmg-Coa Reductase. Science V. 292 1160 2001.
ISSN: ISSN 0036-8075
PubMed: 11349148
DOI: 10.1126/SCIENCE.1059344
Page generated: Wed Jul 31 11:34:11 2024
ISSN: ISSN 0036-8075
PubMed: 11349148
DOI: 10.1126/SCIENCE.1059344
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