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Fluorine in PDB 1nmx: Crystal Structure of Human Thymidylate Kinase with Fltmp and Adp

Enzymatic activity of Crystal Structure of Human Thymidylate Kinase with Fltmp and Adp

All present enzymatic activity of Crystal Structure of Human Thymidylate Kinase with Fltmp and Adp:
2.7.4.9;

Protein crystallography data

The structure of Crystal Structure of Human Thymidylate Kinase with Fltmp and Adp, PDB code: 1nmx was solved by N.Ostermann, D.Segura-Pena, C.Meier, T.Veit, M.Monnerjahn, M.Konrad, A.Lavie, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 32.10 / 1.70
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 101.515, 101.515, 50.012, 90.00, 90.00, 90.00
R / Rfree (%) 18.3 / 22.8

Other elements in 1nmx:

The structure of Crystal Structure of Human Thymidylate Kinase with Fltmp and Adp also contains other interesting chemical elements:

Magnesium (Mg) 2 atoms

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Crystal Structure of Human Thymidylate Kinase with Fltmp and Adp (pdb code 1nmx). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of Human Thymidylate Kinase with Fltmp and Adp, PDB code: 1nmx:

Fluorine binding site 1 out of 1 in 1nmx

Go back to Fluorine Binding Sites List in 1nmx
Fluorine binding site 1 out of 1 in the Crystal Structure of Human Thymidylate Kinase with Fltmp and Adp


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Crystal Structure of Human Thymidylate Kinase with Fltmp and Adp within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F301

b:19.9
occ:1.00
F A:FDM301 0.0 19.9 1.0
C3' A:FDM301 1.4 20.8 1.0
C4' A:FDM301 2.4 18.9 1.0
C2' A:FDM301 2.4 18.1 1.0
C1' A:FDM301 3.1 16.6 1.0
O A:HOH742 3.1 42.2 1.0
O A:HOH510 3.2 42.8 1.0
O4' A:FDM301 3.2 16.9 1.0
CD1 A:TYR151 3.5 21.9 1.0
C5' A:FDM301 3.6 20.9 1.0
CE2 A:PHE105 3.7 20.9 1.0
O A:HOH684 3.9 33.7 1.0
CB A:TYR151 3.9 22.4 1.0
CD2 A:PHE105 4.0 21.8 1.0
O A:ARG150 4.1 33.6 1.0
O5' A:FDM301 4.2 20.2 1.0
CG A:TYR151 4.2 20.5 1.0
CZ A:PHE105 4.3 22.0 1.0
N1 A:FDM301 4.5 16.3 1.0
CE1 A:TYR151 4.5 22.2 1.0
OP2 A:FDM301 4.6 24.2 1.0
NH2 A:ARG97 4.6 20.2 1.0
O A:HOH512 4.6 42.4 1.0
CD2 A:LEU57 4.6 16.4 1.0
CG A:PHE105 4.8 18.0 1.0
CZ A:ARG97 4.9 16.9 1.0
O2 A:FDM301 5.0 17.7 1.0

Reference:

N.Ostermann, D.Segura-Pena, C.Meier, T.Veit, M.Monnerjahn, M.Konrad, A.Lavie. Structures of Human Thymidylate Kinase in Complex with Prodrugs: Implications For the Structure-Based Design of Novel Compounds Biochemistry V. 42 2568 2003.
ISSN: ISSN 0006-2960
PubMed: 12614151
DOI: 10.1021/BI027302T
Page generated: Mon Jul 14 11:23:30 2025

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