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Fluorine in PDB 1sve: Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 1
Enzymatic activity of Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 1
All present enzymatic activity of Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 1:
2.7.1.37;
2.7.1.37;
Protein crystallography data
The structure of Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 1, PDB code: 1sve
was solved by
C.B.Breitenlechner,
T.Wegge,
L.Berillon,
K.Graul,
K.Marzenell,
W.-G.Friebe,
U.Thomas,
R.Schumacher,
R.Huber,
R.A.Engh,
B.Masjost,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 20.94 / 2.49 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 74.240, 76.320, 79.740, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 19.9 / 25.7 |
Other elements in 1sve:
The structure of Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 1 also contains other interesting chemical elements:
| Sodium | (Na) | 1 atom |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 1
(pdb code 1sve). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 1, PDB code: 1sve:
In total only one binding site of Fluorine was determined in the Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 1, PDB code: 1sve:
Fluorine binding site 1 out of 1 in 1sve
Go back to
Fluorine Binding Sites List in 1sve
Fluorine binding site 1 out
of 1 in the Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 1
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 1 within 5.0Å range:
|
Reference:
C.B.Breitenlechner,
T.Wegge,
L.Berillon,
K.Graul,
K.Marzenell,
W.-G.Friebe,
U.Thomas,
R.Schumacher,
R.Huber,
R.A.Engh,
B.Masjost.
Structure-Based Optimization of Novel Azepane Derivatives As Pkb Inhibitors J.Med.Chem. V. 47 1375 2004.
ISSN: ISSN 0022-2623
PubMed: 14998327
DOI: 10.1021/JM0310479
Page generated: Mon Jul 14 11:56:48 2025
ISSN: ISSN 0022-2623
PubMed: 14998327
DOI: 10.1021/JM0310479
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