Atomistry » Fluorine » PDB 1udb-1w5y » 1vzc
Atomistry »
  Fluorine »
    PDB 1udb-1w5y »
      1vzc »

Fluorine in PDB 1vzc: L. Casei Thymidylate Synthase Mutant E60Q Binary Complex with Fdump

Enzymatic activity of L. Casei Thymidylate Synthase Mutant E60Q Binary Complex with Fdump

All present enzymatic activity of L. Casei Thymidylate Synthase Mutant E60Q Binary Complex with Fdump:
2.1.1.45;

Protein crystallography data

The structure of L. Casei Thymidylate Synthase Mutant E60Q Binary Complex with Fdump, PDB code: 1vzc was solved by D.L.Birdsall, J.Finer-Moore, R.M.Stroud, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 15.00 / 2.50
Space group P 61 2 2
Cell size a, b, c (Å), α, β, γ (°) 79.500, 79.500, 229.100, 90.00, 90.00, 120.00
R / Rfree (%) 20.1 / n/a

Fluorine Binding Sites:

The binding sites of Fluorine atom in the L. Casei Thymidylate Synthase Mutant E60Q Binary Complex with Fdump (pdb code 1vzc). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the L. Casei Thymidylate Synthase Mutant E60Q Binary Complex with Fdump, PDB code: 1vzc:

Fluorine binding site 1 out of 1 in 1vzc

Go back to Fluorine Binding Sites List in 1vzc
Fluorine binding site 1 out of 1 in the L. Casei Thymidylate Synthase Mutant E60Q Binary Complex with Fdump


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of L. Casei Thymidylate Synthase Mutant E60Q Binary Complex with Fdump within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F317

b:13.6
occ:1.00
F5 A:UFP317 0.0 13.6 1.0
C5 A:UFP317 1.3 26.3 1.0
H2 A:HOH320 2.0 15.0 1.0
C6 A:UFP317 2.3 25.8 1.0
C4 A:UFP317 2.4 25.1 1.0
H1 A:HOH359 2.5 15.0 1.0
O4 A:UFP317 2.9 23.3 1.0
O A:HOH320 2.9 2.0 1.0
O A:HOH359 3.2 52.2 1.0
H1 A:HOH331 3.3 15.0 1.0
CD1 A:LEU195 3.3 19.8 1.0
H1 A:HOH320 3.4 15.0 1.0
N1 A:UFP317 3.6 26.7 1.0
N3 A:UFP317 3.7 24.7 1.0
O A:HOH331 3.7 27.7 1.0
CG A:LEU195 3.8 20.6 1.0
H2 A:HOH359 3.9 15.0 1.0
C2 A:UFP317 4.2 24.7 1.0
H2 A:HOH331 4.3 15.0 1.0
CD2 A:LEU195 4.3 18.2 1.0
SG A:CYS198 4.3 13.0 1.0
HN3 A:UFP317 4.5 15.0 1.0
H1 A:HOH322 4.5 15.0 1.0
H A:CYS198 4.6 15.0 1.0
CB A:CYS198 4.6 9.8 1.0
C1' A:UFP317 4.7 26.8 1.0
O A:HOH322 4.7 25.9 1.0
O4' A:UFP317 4.9 28.2 1.0

Reference:

D.L.Birdsall, W.Huang, D.V.Santi, R.M.Stroud, J.Finer-Moore. The Separate Effects of E60Q in Lactobacillus Casei Thymidylate Synthase Delineate Between Mechanisms For Formation of Intermediates in Catalysis. Protein Eng. V. 11 171 1998.
ISSN: ISSN 0269-2139
PubMed: 9613841
DOI: 10.1093/PROTEIN/11.3.171
Page generated: Mon Jul 14 12:09:03 2025

Last articles

Fe in 7BHC
Fe in 7BIU
Fe in 7BI1
Fe in 7B9A
Fe in 7BGI
Fe in 7BHB
Fe in 7B97
Fe in 7BHA
Fe in 7BBT
Fe in 7BET
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy