Fluorine in PDB 1yw9: H-METAP2 Complexed with A849519

All present enzymatic activity of H-METAP2 Complexed with A849519:
3.4.11.18;

The structure of H-METAP2 Complexed with A849519, PDB code: 1yw9 was solved by C.H.Park, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	18.68 / 1.64
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	89.956, 98.801, 100.904, 90.00, 90.00, 90.00
R / Rfree (%)	n/a / n/a

The structure of H-METAP2 Complexed with A849519 also contains other interesting chemical elements:

Manganese

(Mn)

2 atoms

The binding sites of Fluorine atom in the H-METAP2 Complexed with A849519 (pdb code 1yw9). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the H-METAP2 Complexed with A849519, PDB code: 1yw9:

Fluorine binding site 1 out of 1 in the H-METAP2 Complexed with A849519


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of H-METAP2 Complexed with A849519 within 5.0Å range: probe atom residue distance (Å) B Occ A:F482 b:18.8 occ:1.00 F24 A:A84482 0.0 18.8 1.0 C21 A:A84482 1.3 18.8 1.0 C20 A:A84482 2.3 18.9 1.0 C22 A:A84482 2.4 18.7 1.0 CB A:ALA230 3.1 15.3 1.0 CD2 A:LEU328 3.4 18.8 1.0 CZ A:PHE366 3.4 15.8 1.0 C23 A:A84482 3.6 18.6 1.0 C19 A:A84482 3.6 18.9 1.0 CE2 A:PHE366 3.9 15.9 1.0 CD1 A:LEU328 3.9 18.7 1.0 CD1 A:LEU447 4.0 17.3 1.0 C18 A:A84482 4.1 18.5 1.0 CE1 A:PHE366 4.2 15.9 1.0 CG A:LEU328 4.2 18.8 1.0 NE2 A:HIS231 4.3 15.9 1.0 CD2 A:HIS231 4.5 15.9 1.0 CA A:ALA230 4.6 15.3 1.0 O13 A:A84482 4.6 17.1 1.0 CE1 A:HIS231 4.7 16.0 1.0 OE2 A:GLU364 4.7 16.0 1.0 CB A:LEU328 4.8 18.9 1.0 C25 A:A84482 4.9 19.3 1.0 CD2 A:PHE366 4.9 15.9 1.0

G.S.Sheppard, J.Wang, M.Kawai, S.D.Fidanze, N.Y.Bamaung, S.A.Erickson, D.M.Barnes, J.S.Tedrow, L.Kolaczkowski, A.Vasudevan, D.C.Park, G.T.Wang, W.J.Sanders, R.A.Mantei, F.Palazzo, L.Tucker-Garcia, P.Lou, Q.Zhang, C.H.Park, K.H.Kim, A.Petros, E.Olejniczak, D.Nettesheim, P.Hajduk, J.Henkin, R.Lesniewski, S.K.Davidsen, R.L.Bell. Discovery and Optimization of Anthranilic Acid Sulfonamides As Inhibitors of Methionine Aminopeptidase-2: A Structural Basis For the Reduction of Albumin Binding. J.Med.Chem. V. 49 3832 2006.
ISSN: ISSN 0022-2623
PubMed: 16789740
DOI: 10.1021/JM0601001