Fluorine »
PDB 2gtn-2ihj »
2i78 »
Fluorine in PDB 2i78: Crystal Structure of Human Dipeptidyl Peptidase IV (Dpp IV) Complexed with Abt-341, A Cyclohexene-Constrained Phenethylamine Inhibitor
Enzymatic activity of Crystal Structure of Human Dipeptidyl Peptidase IV (Dpp IV) Complexed with Abt-341, A Cyclohexene-Constrained Phenethylamine Inhibitor
All present enzymatic activity of Crystal Structure of Human Dipeptidyl Peptidase IV (Dpp IV) Complexed with Abt-341, A Cyclohexene-Constrained Phenethylamine Inhibitor:
3.4.14.5;
3.4.14.5;
Protein crystallography data
The structure of Crystal Structure of Human Dipeptidyl Peptidase IV (Dpp IV) Complexed with Abt-341, A Cyclohexene-Constrained Phenethylamine Inhibitor, PDB code: 2i78
was solved by
K.L.Longenecker,
Z.Pei,
X.Li,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 129.10 / 2.50 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 119.933, 126.419, 127.531, 90.00, 100.26, 90.00 |
| R / Rfree (%) | 21.6 / 27.5 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Human Dipeptidyl Peptidase IV (Dpp IV) Complexed with Abt-341, A Cyclohexene-Constrained Phenethylamine Inhibitor
(pdb code 2i78). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Crystal Structure of Human Dipeptidyl Peptidase IV (Dpp IV) Complexed with Abt-341, A Cyclohexene-Constrained Phenethylamine Inhibitor, PDB code: 2i78:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;
In total 6 binding sites of Fluorine where determined in the Crystal Structure of Human Dipeptidyl Peptidase IV (Dpp IV) Complexed with Abt-341, A Cyclohexene-Constrained Phenethylamine Inhibitor, PDB code: 2i78:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;
Fluorine binding site 1 out of 6 in 2i78
Go back to
Fluorine Binding Sites List in 2i78
Fluorine binding site 1 out
of 6 in the Crystal Structure of Human Dipeptidyl Peptidase IV (Dpp IV) Complexed with Abt-341, A Cyclohexene-Constrained Phenethylamine Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of Human Dipeptidyl Peptidase IV (Dpp IV) Complexed with Abt-341, A Cyclohexene-Constrained Phenethylamine Inhibitor within 5.0Å range:
|
Fluorine binding site 2 out of 6 in 2i78
Go back to
Fluorine Binding Sites List in 2i78
Fluorine binding site 2 out
of 6 in the Crystal Structure of Human Dipeptidyl Peptidase IV (Dpp IV) Complexed with Abt-341, A Cyclohexene-Constrained Phenethylamine Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of Human Dipeptidyl Peptidase IV (Dpp IV) Complexed with Abt-341, A Cyclohexene-Constrained Phenethylamine Inhibitor within 5.0Å range:
|
Fluorine binding site 3 out of 6 in 2i78
Go back to
Fluorine Binding Sites List in 2i78
Fluorine binding site 3 out
of 6 in the Crystal Structure of Human Dipeptidyl Peptidase IV (Dpp IV) Complexed with Abt-341, A Cyclohexene-Constrained Phenethylamine Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of Human Dipeptidyl Peptidase IV (Dpp IV) Complexed with Abt-341, A Cyclohexene-Constrained Phenethylamine Inhibitor within 5.0Å range:
|
Fluorine binding site 4 out of 6 in 2i78
Go back to
Fluorine Binding Sites List in 2i78
Fluorine binding site 4 out
of 6 in the Crystal Structure of Human Dipeptidyl Peptidase IV (Dpp IV) Complexed with Abt-341, A Cyclohexene-Constrained Phenethylamine Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Crystal Structure of Human Dipeptidyl Peptidase IV (Dpp IV) Complexed with Abt-341, A Cyclohexene-Constrained Phenethylamine Inhibitor within 5.0Å range:
|
Fluorine binding site 5 out of 6 in 2i78
Go back to
Fluorine Binding Sites List in 2i78
Fluorine binding site 5 out
of 6 in the Crystal Structure of Human Dipeptidyl Peptidase IV (Dpp IV) Complexed with Abt-341, A Cyclohexene-Constrained Phenethylamine Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 5 of Crystal Structure of Human Dipeptidyl Peptidase IV (Dpp IV) Complexed with Abt-341, A Cyclohexene-Constrained Phenethylamine Inhibitor within 5.0Å range:
|
Fluorine binding site 6 out of 6 in 2i78
Go back to
Fluorine Binding Sites List in 2i78
Fluorine binding site 6 out
of 6 in the Crystal Structure of Human Dipeptidyl Peptidase IV (Dpp IV) Complexed with Abt-341, A Cyclohexene-Constrained Phenethylamine Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 6 of Crystal Structure of Human Dipeptidyl Peptidase IV (Dpp IV) Complexed with Abt-341, A Cyclohexene-Constrained Phenethylamine Inhibitor within 5.0Å range:
|
Reference:
Z.Pei,
X.Li,
T.W.Vongeldern,
D.J.Madar,
K.L Longenecker,
H.Yong,
T.H.Lubben,
K.D.Stewart,
B.A.Zinker,
B.J.Backes,
A.S.Judd,
M.Mulhern,
S.J.Ballaron,
M.A.Stashko,
A.K.Mika,
D.W.A.Beno,
G.A.Reinhart,
R.M.Fryer,
L.C.Preusser,
A.J.Kempf-Grote,
H.L.Sham,
J.M.Trevillyan.
Discovery of Cyclohexene-Constrained Phenethylamine Abt-341, A Highly Potent, Selective, Orally Bioavailable, Safe and Potential Next-Generation Dipeptidyl Peptidase IV Inhibitor For the Treatment of Type 2 Diabetes To Be Published.
Page generated: Mon Jul 14 13:26:36 2025
Last articles
Mn in 9LJUMn in 9LJW
Mn in 9LJS
Mn in 9LJR
Mn in 9LJT
Mn in 9LJV
Mg in 9UA2
Mg in 9R96
Mg in 9VM1
Mg in 9P01
