Fluorine in PDB 2ity: Crystal Structure of Egfr Kinase Domain in Complex with Iressa

All present enzymatic activity of Crystal Structure of Egfr Kinase Domain in Complex with Iressa:
2.7.10.1;

The structure of Crystal Structure of Egfr Kinase Domain in Complex with Iressa, PDB code: 2ity was solved by C.-H.Yun, T.J.Boggon, Y.Li, S.Woo, H.Greulich, M.Meyerson, M.J.Eck, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	24.89 / 3.42
Space group	I 2 3
Cell size a, b, c (Å), α, β, γ (°)	145.140, 145.140, 145.140, 90.00, 90.00, 90.00
R / Rfree (%)	21.1 / 26

The structure of Crystal Structure of Egfr Kinase Domain in Complex with Iressa also contains other interesting chemical elements:

Chlorine

(Cl)

1 atom

The binding sites of Fluorine atom in the Crystal Structure of Egfr Kinase Domain in Complex with Iressa (pdb code 2ity). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of Egfr Kinase Domain in Complex with Iressa, PDB code: 2ity:

Fluorine binding site 1 out of 1 in the Crystal Structure of Egfr Kinase Domain in Complex with Iressa


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Crystal Structure of Egfr Kinase Domain in Complex with Iressa within 5.0Å range: probe atom residue distance (Å) B Occ A:F2020 b:95.8 occ:1.00 FAB A:IRE2020 0.0 95.8 1.0 CAW A:IRE2020 1.3 98.0 1.0 CAX A:IRE2020 2.4 98.9 1.0 CAD A:IRE2020 2.4 98.2 1.0 CL A:IRE2020 2.9 0.5 1.0 CE A:MET766 2.9 38.5 1.0 CD2 A:LEU788 3.1 53.0 1.0 OE2 A:GLU762 3.4 62.6 1.0 CAG A:IRE2020 3.6 99.2 1.0 CAE A:IRE2020 3.6 99.0 1.0 NZ A:LYS745 3.8 55.5 1.0 CE A:LYS745 3.8 58.4 1.0 SD A:MET766 3.8 40.2 1.0 CAY A:IRE2020 4.1 99.2 1.0 CD A:LYS745 4.1 60.0 1.0 CD A:GLU762 4.4 58.9 1.0 CG A:LEU788 4.6 50.1 1.0 OE1 A:GLU762 4.7 60.7 1.0 CB A:LYS745 4.7 67.0 1.0 CB A:LEU788 4.9 49.7 1.0 CG A:LYS745 5.0 64.6 1.0

C.-H.Yun, T.J.Boggon, Y.Li, S.Woo, H.Greulich, M.Meyerson, M.J.Eck. Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity Cancer Cell V. 11 217 2007.
ISSN: ISSN 1535-6108
PubMed: 17349580
DOI: 10.1016/J.CCR.2006.12.017