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Atomistry » Fluorine » PDB 2weg-2x2f » 2x1n | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 2weg-2x2f » 2x1n » |
Fluorine in PDB 2x1n: Truncation and Optimisation of Peptide Inhibitors of CDK2, Cyclin A Through Structure Guided DesignEnzymatic activity of Truncation and Optimisation of Peptide Inhibitors of CDK2, Cyclin A Through Structure Guided Design
All present enzymatic activity of Truncation and Optimisation of Peptide Inhibitors of CDK2, Cyclin A Through Structure Guided Design:
2.7.1.37; Protein crystallography data
The structure of Truncation and Optimisation of Peptide Inhibitors of CDK2, Cyclin A Through Structure Guided Design, PDB code: 2x1n
was solved by
G.Kontopidis,
M.J.Andrews,
C.Mcinnes,
A.Plater,
L.Innes,
S.Renachowski,
A.Cowan,
P.M.Fischer,
N.A.Mcintyre,
G.Griffiths,
A.L.Barnett,
A.M.Z.Slawin,
W.Jackson,
M.Thomas,
D.I.Zheleva,
S.Wang,
D.G.Blake,
N.J.Westwood,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Truncation and Optimisation of Peptide Inhibitors of CDK2, Cyclin A Through Structure Guided Design
(pdb code 2x1n). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Truncation and Optimisation of Peptide Inhibitors of CDK2, Cyclin A Through Structure Guided Design, PDB code: 2x1n: Fluorine binding site 1 out of 1 in 2x1nGo back to![]() ![]()
Fluorine binding site 1 out
of 1 in the Truncation and Optimisation of Peptide Inhibitors of CDK2, Cyclin A Through Structure Guided Design
![]() Mono view ![]() Stereo pair view
Reference:
N.A.Mcintyre,
C.Mcinnes,
G.Griffiths,
A.L.Barnett,
G.Kontopidis,
A.M.Z.Slawin,
W.Jackson,
M.Thomas,
D.I.Zheleva,
S.Wang,
D.G.Blake,
N.J.Westwood,
P.M.Fischer.
Design, Synthesis, and Evaluation of 2-Methyl- and 2-Amino-N-Aryl-4,5-Dihydrothiazolo[4,5-H]Quinazolin-8-Amines As Ring-Constrained 2-Anilino-4-(Thiazol-5-Yl)Pyrimidine Cyclin-Dependent Kinase Inhibitors. J.Med.Chem. V. 53 2136 2010.
Page generated: Wed Jul 31 16:33:01 2024
ISSN: ISSN 0022-2623 PubMed: 20146435 DOI: 10.1021/JM901660C |
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