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Atomistry » Fluorine » PDB 2y1x-2z5z » 2ynf | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 2y1x-2z5z » 2ynf » |
Fluorine in PDB 2ynf: Hiv-1 Reverse Transcriptase Y188L Mutant in Complex with Inhibitor GSK560Enzymatic activity of Hiv-1 Reverse Transcriptase Y188L Mutant in Complex with Inhibitor GSK560
All present enzymatic activity of Hiv-1 Reverse Transcriptase Y188L Mutant in Complex with Inhibitor GSK560:
2.7.7.49; 2.7.7.7; 3.1.13.2; 3.1.26.13; Protein crystallography data
The structure of Hiv-1 Reverse Transcriptase Y188L Mutant in Complex with Inhibitor GSK560, PDB code: 2ynf
was solved by
P.Chong,
P.Sebahar,
M.Youngman,
D.Garrido,
H.Zhang,
E.L.Stewart,
R.T.Nolte,
L.Wang,
R.G.Ferris,
M.Edelstein,
K.Weaver,
A.Mathis,
A.Peat,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 2ynf:
The structure of Hiv-1 Reverse Transcriptase Y188L Mutant in Complex with Inhibitor GSK560 also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Hiv-1 Reverse Transcriptase Y188L Mutant in Complex with Inhibitor GSK560
(pdb code 2ynf). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Hiv-1 Reverse Transcriptase Y188L Mutant in Complex with Inhibitor GSK560, PDB code: 2ynf: Fluorine binding site 1 out of 1 in 2ynfGo back to![]() ![]()
Fluorine binding site 1 out
of 1 in the Hiv-1 Reverse Transcriptase Y188L Mutant in Complex with Inhibitor GSK560
![]() Mono view ![]() Stereo pair view
Reference:
P.Chong,
P.Sebahar,
M.Youngman,
D.Garrido,
H.Zhang,
E.L.Stewart,
R.T.Nolte,
L.Wang,
R.G.Ferris,
M.Edelstein,
K.Weaver,
A.Mathis,
A.Peat.
Rational Design of Potent Non-Nucleoside Inhibitors of Hiv- 1 Reverse Transcriptase. J.Med.Chem. V. 55 10601 2012.
Page generated: Wed Jul 31 16:53:54 2024
ISSN: ISSN 0022-2623 PubMed: 23137340 DOI: 10.1021/JM301294G |
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