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Fluorine in PDB 3a4p: Human C-Met Kinase Domain Complexed with 6-Benzyloxyquinoline Inhibitor
Enzymatic activity of Human C-Met Kinase Domain Complexed with 6-Benzyloxyquinoline Inhibitor
All present enzymatic activity of Human C-Met Kinase Domain Complexed with 6-Benzyloxyquinoline Inhibitor:
2.7.10.1;
2.7.10.1;
Protein crystallography data
The structure of Human C-Met Kinase Domain Complexed with 6-Benzyloxyquinoline Inhibitor, PDB code: 3a4p
was solved by
T.A.Fukami,
S.Kadono,
M.Yamamuro,
T.Matsuura,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 44.86 / 2.54 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 157.227, 42.733, 46.039, 90.00, 102.91, 90.00 |
| R / Rfree (%) | 18.3 / 24 |
Other elements in 3a4p:
The structure of Human C-Met Kinase Domain Complexed with 6-Benzyloxyquinoline Inhibitor also contains other interesting chemical elements:
| Chlorine | (Cl) | 3 atoms |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Human C-Met Kinase Domain Complexed with 6-Benzyloxyquinoline Inhibitor
(pdb code 3a4p). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Human C-Met Kinase Domain Complexed with 6-Benzyloxyquinoline Inhibitor, PDB code: 3a4p:
In total only one binding site of Fluorine was determined in the Human C-Met Kinase Domain Complexed with 6-Benzyloxyquinoline Inhibitor, PDB code: 3a4p:
Fluorine binding site 1 out of 1 in 3a4p
Go back to
Fluorine Binding Sites List in 3a4p
Fluorine binding site 1 out
of 1 in the Human C-Met Kinase Domain Complexed with 6-Benzyloxyquinoline Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Human C-Met Kinase Domain Complexed with 6-Benzyloxyquinoline Inhibitor within 5.0Å range:
|
Reference:
H.Nishii,
T.Chiba,
K.Morikami,
T.A.Fukami,
H.Sakamoto,
K.Ko,
H.Koyano.
Discovery of 6-Benzyloxyquinolines As C-Met Selective Kinase Inhibitors Bioorg.Med.Chem.Lett. V. 20 1405 2010.
ISSN: ISSN 0960-894X
PubMed: 20093027
DOI: 10.1016/J.BMCL.2009.12.109
Page generated: Wed Jul 31 17:04:16 2024
ISSN: ISSN 0960-894X
PubMed: 20093027
DOI: 10.1016/J.BMCL.2009.12.109
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