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Atomistry » Fluorine » PDB 3b0q-3cct » 3bcj » |
Fluorine in PDB 3bcj: Crystal Structure of Aldose Reductase Complexed with 2S4R (Stereoisomer of Fidarestat, 2S4S) at 0.78 AEnzymatic activity of Crystal Structure of Aldose Reductase Complexed with 2S4R (Stereoisomer of Fidarestat, 2S4S) at 0.78 A
All present enzymatic activity of Crystal Structure of Aldose Reductase Complexed with 2S4R (Stereoisomer of Fidarestat, 2S4S) at 0.78 A:
1.1.1.21; Protein crystallography data
The structure of Crystal Structure of Aldose Reductase Complexed with 2S4R (Stereoisomer of Fidarestat, 2S4S) at 0.78 A, PDB code: 3bcj
was solved by
H.T.Zhao,
O.El-Kabbani,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Aldose Reductase Complexed with 2S4R (Stereoisomer of Fidarestat, 2S4S) at 0.78 A
(pdb code 3bcj). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of Aldose Reductase Complexed with 2S4R (Stereoisomer of Fidarestat, 2S4S) at 0.78 A, PDB code: 3bcj: Fluorine binding site 1 out of 1 in 3bcjGo back to![]() ![]()
Fluorine binding site 1 out
of 1 in the Crystal Structure of Aldose Reductase Complexed with 2S4R (Stereoisomer of Fidarestat, 2S4S) at 0.78 A
![]() Mono view ![]() Stereo pair view
Reference:
H.T.Zhao,
I.Hazemann,
A.Mitschler,
V.Carbone,
A.Joachimiak,
S.Ginell,
A.Podjarny,
O.El-Kabbani.
Unusual Binding Mode of the 2S4R Stereoisomer of the Potent Aldose Reductase Cyclic Imide Inhibitor Fidarestat (2S4S) in the 15 K Crystal Structure of the Ternary Complex Refined at 0.78 A Resolution: Implications For the Inhibition Mechanism J.Med.Chem. V. 51 1478 2008.
Page generated: Wed Jul 31 17:15:59 2024
ISSN: ISSN 0022-2623 PubMed: 18284183 DOI: 10.1021/JM701514K |
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