|
Atomistry » Fluorine » PDB 3fls-3g70 » 3g0e | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 3fls-3g70 » 3g0e » |
Fluorine in PDB 3g0e: Kit Kinase Domain in Complex with SunitinibEnzymatic activity of Kit Kinase Domain in Complex with Sunitinib
All present enzymatic activity of Kit Kinase Domain in Complex with Sunitinib:
2.7.10.1; Protein crystallography data
The structure of Kit Kinase Domain in Complex with Sunitinib, PDB code: 3g0e
was solved by
K.S.Gajiwala,
J.C.Wu,
E.A.Lunney,
G.D.Gemetri,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Kit Kinase Domain in Complex with Sunitinib
(pdb code 3g0e). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Kit Kinase Domain in Complex with Sunitinib, PDB code: 3g0e: Fluorine binding site 1 out of 1 in 3g0eGo back to![]() ![]()
Fluorine binding site 1 out
of 1 in the Kit Kinase Domain in Complex with Sunitinib
![]() Mono view ![]() Stereo pair view
Reference:
K.S.Gajiwala,
J.C.Wu,
J.Christensen,
G.D.Deshmukh,
W.Diehl,
J.P.Dinitto,
J.M.English,
M.J.Greig,
Y.A.He,
S.L.Jacques,
E.A.Lunney,
M.Mctigue,
D.Molina,
T.Quenzer,
P.A.Wells,
X.Yu,
Y.Zhang,
A.Zou,
M.R.Emmett,
A.G.Marshall,
H.M.Zhang,
G.D.Demetri.
Kit Kinase Mutants Show Unique Mechanisms of Drug Resistance to Imatinib and Sunitinib in Gastrointestinal Stromal Tumor Patients. Proc.Natl.Acad.Sci.Usa V. 106 1542 2009.
Page generated: Wed Jul 31 18:42:41 2024
ISSN: ISSN 0027-8424 PubMed: 19164557 DOI: 10.1073/PNAS.0812413106 |
Last articlesZn in 9MJ5Zn in 9HNW Zn in 9G0L Zn in 9FNE Zn in 9DZN Zn in 9E0I Zn in 9D32 Zn in 9DAK Zn in 8ZXC Zn in 8ZUF |
© Copyright 2008-2020 by atomistry.com | ||
Home | Site Map | Copyright | Contact us | Privacy |