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Fluorine in PDB 3iu8: M. Tuberculosis Methionine Aminopeptidase with Ni Inhibitor T03

Enzymatic activity of M. Tuberculosis Methionine Aminopeptidase with Ni Inhibitor T03

All present enzymatic activity of M. Tuberculosis Methionine Aminopeptidase with Ni Inhibitor T03:
3.4.11.18;

Protein crystallography data

The structure of M. Tuberculosis Methionine Aminopeptidase with Ni Inhibitor T03, PDB code: 3iu8 was solved by Q.Z.Ye, J.P.Lu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 36.49 / 1.85
Space group P 63
Cell size a, b, c (Å), α, β, γ (°) 105.728, 105.728, 50.427, 90.00, 90.00, 120.00
R / Rfree (%) 16.5 / 20

Other elements in 3iu8:

The structure of M. Tuberculosis Methionine Aminopeptidase with Ni Inhibitor T03 also contains other interesting chemical elements:

Nickel (Ni) 3 atoms
Chlorine (Cl) 2 atoms

Fluorine Binding Sites:

The binding sites of Fluorine atom in the M. Tuberculosis Methionine Aminopeptidase with Ni Inhibitor T03 (pdb code 3iu8). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the M. Tuberculosis Methionine Aminopeptidase with Ni Inhibitor T03, PDB code: 3iu8:

Fluorine binding site 1 out of 1 in 3iu8

Go back to Fluorine Binding Sites List in 3iu8
Fluorine binding site 1 out of 1 in the M. Tuberculosis Methionine Aminopeptidase with Ni Inhibitor T03


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of M. Tuberculosis Methionine Aminopeptidase with Ni Inhibitor T03 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F289

b:33.8
occ:1.00
F A:T03289 0.0 33.8 1.0
C4 A:T03289 1.4 27.8 1.0
C5 A:T03289 2.4 24.5 1.0
C3 A:T03289 2.4 25.4 1.0
CE2 A:TYR97 3.3 20.6 1.0
CZ3 A:TRP255 3.3 26.5 1.0
C6 A:T03289 3.6 26.6 1.0
CD2 A:TYR97 3.7 17.8 1.0
C2 A:T03289 3.7 26.4 1.0
CH2 A:TRP255 3.9 23.4 1.0
CE1 A:HIS114 4.0 18.1 1.0
C1 A:T03289 4.2 22.6 1.0
NE2 A:HIS114 4.3 14.3 1.0
CE3 A:TRP255 4.3 19.6 1.0
ND1 A:HIS114 4.4 15.2 1.0
CZ A:TYR97 4.5 19.2 1.0
CD A:LYS98 4.7 19.2 1.0
OH A:TYR97 4.8 15.6 1.0
CL A:CL292 4.9 30.0 1.0
CD2 A:HIS114 5.0 13.9 1.0

Reference:

J.P.Lu, S.C.Chai, Q.Z.Ye. Catalysis and Inhibition of Mycobacterium Tuberculosis Methionine Aminopeptidase J.Med.Chem. V. 53 1329 2010.
ISSN: ISSN 0022-2623
PubMed: 20038112
DOI: 10.1021/JM901624N
Page generated: Mon Jul 14 17:06:00 2025

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