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Atomistry » Fluorine » PDB 3nlz-3og7 » 3o8a » |
Fluorine in PDB 3o8a: Crystal Structure of Plasmodium Falciparum Dihydroorotate Dehydrogenase Bound with Novel Inhibitor GENZ667348Enzymatic activity of Crystal Structure of Plasmodium Falciparum Dihydroorotate Dehydrogenase Bound with Novel Inhibitor GENZ667348
All present enzymatic activity of Crystal Structure of Plasmodium Falciparum Dihydroorotate Dehydrogenase Bound with Novel Inhibitor GENZ667348:
1.3.5.2; Protein crystallography data
The structure of Crystal Structure of Plasmodium Falciparum Dihydroorotate Dehydrogenase Bound with Novel Inhibitor GENZ667348, PDB code: 3o8a
was solved by
X.Deng,
M.L.Booker,
M.A.Phillips,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Plasmodium Falciparum Dihydroorotate Dehydrogenase Bound with Novel Inhibitor GENZ667348
(pdb code 3o8a). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Crystal Structure of Plasmodium Falciparum Dihydroorotate Dehydrogenase Bound with Novel Inhibitor GENZ667348, PDB code: 3o8a: Jump to Fluorine binding site number: 1; 2; 3; Fluorine binding site 1 out of 3 in 3o8aGo back to![]() ![]()
Fluorine binding site 1 out
of 3 in the Crystal Structure of Plasmodium Falciparum Dihydroorotate Dehydrogenase Bound with Novel Inhibitor GENZ667348
![]() Mono view ![]() Stereo pair view
Fluorine binding site 2 out of 3 in 3o8aGo back to![]() ![]()
Fluorine binding site 2 out
of 3 in the Crystal Structure of Plasmodium Falciparum Dihydroorotate Dehydrogenase Bound with Novel Inhibitor GENZ667348
![]() Mono view ![]() Stereo pair view
Fluorine binding site 3 out of 3 in 3o8aGo back to![]() ![]()
Fluorine binding site 3 out
of 3 in the Crystal Structure of Plasmodium Falciparum Dihydroorotate Dehydrogenase Bound with Novel Inhibitor GENZ667348
![]() Mono view ![]() Stereo pair view
Reference:
M.L.Booker,
C.M.Bastos,
M.L.Kramer,
R.H.Barker,
R.Skerlj,
A.B.Sidhu,
X.Deng,
C.Celatka,
J.F.Cortese,
J.E.Guerrero Bravo,
K.N.Crespo Llado,
A.E.Serrano,
I.Angulo-Barturen,
M.B.Jimenez-Diaz,
S.Viera,
H.Garuti,
S.Wittlin,
P.Papastogiannidis,
J.W.Lin,
C.J.Janse,
S.M.Khan,
M.Duraisingh,
B.Coleman,
E.J.Goldsmith,
M.A.Phillips,
B.Munoz,
D.F.Wirth,
J.D.Klinger,
R.Wiegand,
E.Sybertz.
Novel Inhibitors of Plasmodium Falciparum Dihydroorotate Dehydrogenase with Anti-Malarial Activity in the Mouse Model. J.Biol.Chem. V. 285 33054 2010.
Page generated: Mon Jul 14 18:17:14 2025
ISSN: ISSN 0021-9258 PubMed: 20702404 DOI: 10.1074/JBC.M110.162081 |
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