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Fluorine in PDB 3v9b: Crystal Structure of the Catalytic Domain of PDE4D2 with (S)-N-(3-{1- [1-(3-Cyclopropylmethoxy-4-Difluoromethoxyphenyl)-2-(1-Oxypyridin-4- Yl)-Ethyl]-1H-Pyrazl-3-Yl}Phenyl)Acetamide

Enzymatic activity of Crystal Structure of the Catalytic Domain of PDE4D2 with (S)-N-(3-{1- [1-(3-Cyclopropylmethoxy-4-Difluoromethoxyphenyl)-2-(1-Oxypyridin-4- Yl)-Ethyl]-1H-Pyrazl-3-Yl}Phenyl)Acetamide

All present enzymatic activity of Crystal Structure of the Catalytic Domain of PDE4D2 with (S)-N-(3-{1- [1-(3-Cyclopropylmethoxy-4-Difluoromethoxyphenyl)-2-(1-Oxypyridin-4- Yl)-Ethyl]-1H-Pyrazl-3-Yl}Phenyl)Acetamide:
3.1.4.17;

Protein crystallography data

The structure of Crystal Structure of the Catalytic Domain of PDE4D2 with (S)-N-(3-{1- [1-(3-Cyclopropylmethoxy-4-Difluoromethoxyphenyl)-2-(1-Oxypyridin-4- Yl)-Ethyl]-1H-Pyrazl-3-Yl}Phenyl)Acetamide, PDB code: 3v9b was solved by H.T.Kim, H.J.Chang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 35.41 / 2.10
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 98.587, 110.293, 161.607, 90.00, 90.00, 90.00
R / Rfree (%) 20.6 / 23.6

Other elements in 3v9b:

The structure of Crystal Structure of the Catalytic Domain of PDE4D2 with (S)-N-(3-{1- [1-(3-Cyclopropylmethoxy-4-Difluoromethoxyphenyl)-2-(1-Oxypyridin-4- Yl)-Ethyl]-1H-Pyrazl-3-Yl}Phenyl)Acetamide also contains other interesting chemical elements:

Zinc (Zn) 8 atoms

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Crystal Structure of the Catalytic Domain of PDE4D2 with (S)-N-(3-{1- [1-(3-Cyclopropylmethoxy-4-Difluoromethoxyphenyl)-2-(1-Oxypyridin-4- Yl)-Ethyl]-1H-Pyrazl-3-Yl}Phenyl)Acetamide (pdb code 3v9b). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 8 binding sites of Fluorine where determined in the Crystal Structure of the Catalytic Domain of PDE4D2 with (S)-N-(3-{1- [1-(3-Cyclopropylmethoxy-4-Difluoromethoxyphenyl)-2-(1-Oxypyridin-4- Yl)-Ethyl]-1H-Pyrazl-3-Yl}Phenyl)Acetamide, PDB code: 3v9b:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Fluorine binding site 1 out of 8 in 3v9b

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Fluorine binding site 1 out of 8 in the Crystal Structure of the Catalytic Domain of PDE4D2 with (S)-N-(3-{1- [1-(3-Cyclopropylmethoxy-4-Difluoromethoxyphenyl)-2-(1-Oxypyridin-4- Yl)-Ethyl]-1H-Pyrazl-3-Yl}Phenyl)Acetamide


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Crystal Structure of the Catalytic Domain of PDE4D2 with (S)-N-(3-{1- [1-(3-Cyclopropylmethoxy-4-Difluoromethoxyphenyl)-2-(1-Oxypyridin-4- Yl)-Ethyl]-1H-Pyrazl-3-Yl}Phenyl)Acetamide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F1

b:27.5
occ:1.00
 F09 A:IHM1 0.0 27.5 1.0
C08 A:IHM1 1.4 27.2 1.0
F10 A:IHM1 2.2 26.2 1.0
O07 A:IHM1 2.3 25.9 1.0
C01 A:IHM1 3.1 25.8 1.0
N A:THR333 3.1 22.3 1.0
C A:TRP332 3.1 23.0 1.0
C02 A:IHM1 3.2 25.3 1.0
O A:TRP332 3.3 22.4 1.0
CA A:THR333 3.3 23.7 1.0
CB A:TRP332 3.4 20.1 1.0
OD1 A:ASN321 3.6 20.4 1.0
OG1 A:THR333 3.7 23.8 1.0
CG2 A:ILE336 3.8 26.0 1.0
CA A:TRP332 3.9 22.4 1.0
CB A:ASN321 4.1 18.9 1.0
CB A:THR333 4.1 23.8 1.0
CB A:ILE336 4.2 24.3 1.0
CG A:ASN321 4.2 21.0 1.0
CE1 A:TYR159 4.3 18.8 1.0
C06 A:IHM1 4.4 26.0 1.0
O A:TYR329 4.5 24.7 1.0
C A:THR333 4.5 25.1 1.0
C03 A:IHM1 4.6 25.2 1.0
CE1 A:TYR329 4.6 20.6 1.0
CG A:TRP332 4.7 20.6 1.0
CD1 A:TYR329 4.7 22.1 1.0
NE2 A:GLN369 4.8 19.8 1.0
O11 A:IHM1 4.9 26.0 1.0
O A:THR333 4.9 24.4 1.0
OE1 A:GLN369 4.9 22.7 1.0
N A:TRP332 5.0 21.9 1.0
CD1 A:TYR159 5.0 18.4 1.0

Fluorine binding site 2 out of 8 in 3v9b

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Fluorine binding site 2 out of 8 in the Crystal Structure of the Catalytic Domain of PDE4D2 with (S)-N-(3-{1- [1-(3-Cyclopropylmethoxy-4-Difluoromethoxyphenyl)-2-(1-Oxypyridin-4- Yl)-Ethyl]-1H-Pyrazl-3-Yl}Phenyl)Acetamide


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Crystal Structure of the Catalytic Domain of PDE4D2 with (S)-N-(3-{1- [1-(3-Cyclopropylmethoxy-4-Difluoromethoxyphenyl)-2-(1-Oxypyridin-4- Yl)-Ethyl]-1H-Pyrazl-3-Yl}Phenyl)Acetamide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F1

b:26.2
occ:1.00
 F10 A:IHM1 0.0 26.2 1.0
C08 A:IHM1 1.4 27.2 1.0
F09 A:IHM1 2.2 27.5 1.0
O07 A:IHM1 2.3 25.9 1.0
C01 A:IHM1 3.0 25.8 1.0
C02 A:IHM1 3.1 25.3 1.0
CB A:ASN321 3.2 18.9 1.0
CE1 A:TYR329 3.2 20.6 1.0
CG A:PRO322 3.6 22.9 1.0
CD A:PRO322 3.7 22.0 1.0
CD1 A:TYR329 3.7 22.1 1.0
OE1 A:GLN369 3.7 22.7 1.0
OD1 A:ASN321 3.8 20.4 1.0
CG A:ASN321 4.0 21.0 1.0
CE2 A:PHE372 4.0 28.9 1.0
OG1 A:THR333 4.1 23.8 1.0
N A:PRO322 4.2 21.4 1.0
C06 A:IHM1 4.3 26.0 1.0
CZ A:TYR329 4.4 22.6 1.0
CA A:ASN321 4.4 18.9 1.0
C A:ASN321 4.4 20.9 1.0
O A:HOH478 4.4 24.7 1.0
C03 A:IHM1 4.4 25.2 1.0
CD A:GLN369 4.5 24.2 1.0
CD2 A:PHE372 4.5 27.3 1.0
CB A:TRP332 4.6 20.1 1.0
NE2 A:GLN369 4.6 19.8 1.0
OH A:TYR329 4.6 21.1 1.0
N A:THR333 4.7 22.3 1.0
O11 A:IHM1 4.8 26.0 1.0
CB A:PRO322 4.8 22.7 1.0
CA A:PRO322 4.9 22.2 1.0
O A:TYR329 4.9 24.7 1.0
CA A:THR333 4.9 23.7 1.0

Fluorine binding site 3 out of 8 in 3v9b

Go back to Fluorine Binding Sites List in 3v9b
Fluorine binding site 3 out of 8 in the Crystal Structure of the Catalytic Domain of PDE4D2 with (S)-N-(3-{1- [1-(3-Cyclopropylmethoxy-4-Difluoromethoxyphenyl)-2-(1-Oxypyridin-4- Yl)-Ethyl]-1H-Pyrazl-3-Yl}Phenyl)Acetamide


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Crystal Structure of the Catalytic Domain of PDE4D2 with (S)-N-(3-{1- [1-(3-Cyclopropylmethoxy-4-Difluoromethoxyphenyl)-2-(1-Oxypyridin-4- Yl)-Ethyl]-1H-Pyrazl-3-Yl}Phenyl)Acetamide within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F1

b:21.7
occ:1.00
 F09 B:IHM1 0.0 21.7 1.0
C08 B:IHM1 1.4 21.6 1.0
F10 B:IHM1 2.2 20.7 1.0
O07 B:IHM1 2.3 21.5 1.0
C01 B:IHM1 3.0 22.9 1.0
C B:TRP332 3.2 23.2 1.0
C02 B:IHM1 3.2 22.2 1.0
O B:TRP332 3.2 23.1 1.0
N B:THR333 3.2 23.2 1.0
CA B:THR333 3.4 22.2 1.0
CB B:TRP332 3.5 24.6 1.0
OD1 B:ASN321 3.5 26.0 1.0
CG2 B:ILE336 3.7 21.8 1.0
OG1 B:THR333 3.7 21.4 1.0
CA B:TRP332 4.0 24.0 1.0
CB B:ILE336 4.1 23.0 1.0
CB B:ASN321 4.1 21.9 1.0
CE1 B:TYR159 4.2 20.5 1.0
CB B:THR333 4.2 22.2 1.0
CG B:ASN321 4.2 23.4 1.0
C06 B:IHM1 4.4 24.1 1.0
C03 B:IHM1 4.5 22.6 1.0
C B:THR333 4.6 23.3 1.0
O B:TYR329 4.6 25.2 1.0
CE1 B:TYR329 4.7 20.9 1.0
CD1 B:TYR159 4.8 20.9 1.0
CG B:TRP332 4.8 26.1 1.0
OE1 B:GLN369 4.8 22.0 1.0
CD1 B:TYR329 4.8 23.1 1.0
O11 B:IHM1 4.8 26.6 1.0
NE2 B:GLN369 4.9 18.2 1.0
O B:THR333 4.9 22.4 1.0
CG1 B:ILE336 5.0 24.9 1.0
CZ B:TYR159 5.0 19.3 1.0

Fluorine binding site 4 out of 8 in 3v9b

Go back to Fluorine Binding Sites List in 3v9b
Fluorine binding site 4 out of 8 in the Crystal Structure of the Catalytic Domain of PDE4D2 with (S)-N-(3-{1- [1-(3-Cyclopropylmethoxy-4-Difluoromethoxyphenyl)-2-(1-Oxypyridin-4- Yl)-Ethyl]-1H-Pyrazl-3-Yl}Phenyl)Acetamide


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Crystal Structure of the Catalytic Domain of PDE4D2 with (S)-N-(3-{1- [1-(3-Cyclopropylmethoxy-4-Difluoromethoxyphenyl)-2-(1-Oxypyridin-4- Yl)-Ethyl]-1H-Pyrazl-3-Yl}Phenyl)Acetamide within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F1

b:20.7
occ:1.00
 F10 B:IHM1 0.0 20.7 1.0
C08 B:IHM1 1.4 21.6 1.0
F09 B:IHM1 2.2 21.7 1.0
O07 B:IHM1 2.3 21.5 1.0
C01 B:IHM1 2.9 22.9 1.0
C02 B:IHM1 3.1 22.2 1.0
CB B:ASN321 3.2 21.9 1.0
CE1 B:TYR329 3.3 20.9 1.0
OE1 B:GLN369 3.6 22.0 1.0
CG B:PRO322 3.6 20.6 1.0
CD B:PRO322 3.7 21.3 1.0
OD1 B:ASN321 3.8 26.0 1.0
CD1 B:TYR329 3.8 23.1 1.0
CE2 B:PHE372 4.0 19.3 1.0
CG B:ASN321 4.0 23.4 1.0
OG1 B:THR333 4.0 21.4 1.0
N B:PRO322 4.2 21.0 1.0
C06 B:IHM1 4.2 24.1 1.0
O B:HOH45 4.3 19.9 1.0
C03 B:IHM1 4.4 22.6 1.0
CA B:ASN321 4.4 21.1 1.0
CD B:GLN369 4.5 20.0 1.0
CZ B:TYR329 4.5 22.8 1.0
CD2 B:PHE372 4.5 18.2 1.0
C B:ASN321 4.5 21.8 1.0
NE2 B:GLN369 4.6 18.2 1.0
CB B:TRP332 4.7 24.6 1.0
OH B:TYR329 4.7 19.9 1.0
O11 B:IHM1 4.8 26.6 1.0
CB B:PRO322 4.8 21.3 1.0
N B:THR333 4.8 23.2 1.0
CA B:PRO322 4.8 21.7 1.0
CA B:THR333 4.9 22.2 1.0

Fluorine binding site 5 out of 8 in 3v9b

Go back to Fluorine Binding Sites List in 3v9b
Fluorine binding site 5 out of 8 in the Crystal Structure of the Catalytic Domain of PDE4D2 with (S)-N-(3-{1- [1-(3-Cyclopropylmethoxy-4-Difluoromethoxyphenyl)-2-(1-Oxypyridin-4- Yl)-Ethyl]-1H-Pyrazl-3-Yl}Phenyl)Acetamide


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Crystal Structure of the Catalytic Domain of PDE4D2 with (S)-N-(3-{1- [1-(3-Cyclopropylmethoxy-4-Difluoromethoxyphenyl)-2-(1-Oxypyridin-4- Yl)-Ethyl]-1H-Pyrazl-3-Yl}Phenyl)Acetamide within 5.0Å range:
probe atom residue distance (Å) B Occ
C:F1

b:30.3
occ:1.00
 F09 C:IHM1 0.0 30.3 1.0
C08 C:IHM1 1.4 26.7 1.0
F10 C:IHM1 2.2 26.1 1.0
O07 C:IHM1 2.3 26.1 1.0
C C:TRP332 2.9 24.2 1.0
O C:TRP332 3.0 25.1 1.0
C01 C:IHM1 3.0 27.5 1.0
N C:THR333 3.1 23.7 1.0
C02 C:IHM1 3.2 26.8 1.0
CB C:TRP332 3.3 21.1 1.0
CA C:THR333 3.3 23.8 1.0
OD1 C:ASN321 3.5 21.4 1.0
CA C:TRP332 3.7 23.5 1.0
OG1 C:THR333 3.7 20.6 1.0
CG2 C:ILE336 3.8 20.6 1.0
CB C:ASN321 4.1 20.0 1.0
CB C:ILE336 4.1 21.2 1.0
CG C:ASN321 4.1 22.6 1.0
CE1 C:TYR159 4.2 18.2 1.0
CB C:THR333 4.2 23.0 1.0
C06 C:IHM1 4.4 27.6 1.0
C C:THR333 4.5 25.3 1.0
O C:TYR329 4.5 23.9 1.0
C03 C:IHM1 4.6 27.6 1.0
CE1 C:TYR329 4.6 27.6 1.0
CG C:TRP332 4.6 22.1 1.0
CD1 C:TYR329 4.7 28.5 1.0
CD1 C:TYR159 4.8 16.0 1.0
OE1 C:GLN369 4.8 24.6 1.0
NE2 C:GLN369 4.8 22.1 1.0
O11 C:IHM1 4.8 27.1 1.0
N C:TRP332 4.9 23.3 1.0
O C:THR333 4.9 26.7 1.0
CZ C:TYR159 5.0 16.9 1.0

Fluorine binding site 6 out of 8 in 3v9b

Go back to Fluorine Binding Sites List in 3v9b
Fluorine binding site 6 out of 8 in the Crystal Structure of the Catalytic Domain of PDE4D2 with (S)-N-(3-{1- [1-(3-Cyclopropylmethoxy-4-Difluoromethoxyphenyl)-2-(1-Oxypyridin-4- Yl)-Ethyl]-1H-Pyrazl-3-Yl}Phenyl)Acetamide


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Crystal Structure of the Catalytic Domain of PDE4D2 with (S)-N-(3-{1- [1-(3-Cyclopropylmethoxy-4-Difluoromethoxyphenyl)-2-(1-Oxypyridin-4- Yl)-Ethyl]-1H-Pyrazl-3-Yl}Phenyl)Acetamide within 5.0Å range:
probe atom residue distance (Å) B Occ
C:F1

b:26.1
occ:1.00
 F10 C:IHM1 0.0 26.1 1.0
C08 C:IHM1 1.4 26.7 1.0
F09 C:IHM1 2.2 30.3 1.0
O07 C:IHM1 2.3 26.1 1.0
C01 C:IHM1 3.0 27.5 1.0
C02 C:IHM1 3.1 26.8 1.0
CB C:ASN321 3.1 20.0 1.0
CE1 C:TYR329 3.2 27.6 1.0
OE1 C:GLN369 3.6 24.6 1.0
OD1 C:ASN321 3.7 21.4 1.0
CG C:PRO322 3.7 24.6 1.0
CD1 C:TYR329 3.7 28.5 1.0
CD C:PRO322 3.8 22.6 1.0
CG C:ASN321 3.9 22.6 1.0
OG1 C:THR333 4.0 20.6 1.0
CE2 C:PHE372 4.1 22.7 1.0
N C:PRO322 4.2 23.8 1.0
O C:HOH32 4.2 23.9 1.0
C06 C:IHM1 4.3 27.6 1.0
CZ C:TYR329 4.4 28.4 1.0
CA C:ASN321 4.4 20.8 1.0
CD C:GLN369 4.4 25.7 1.0
C C:ASN321 4.4 22.9 1.0
C03 C:IHM1 4.4 27.6 1.0
CB C:TRP332 4.5 21.1 1.0
NE2 C:GLN369 4.5 22.1 1.0
CD2 C:PHE372 4.6 21.7 1.0
OH C:TYR329 4.6 27.9 1.0
N C:THR333 4.7 23.7 1.0
O11 C:IHM1 4.8 27.1 1.0
CA C:THR333 4.9 23.8 1.0
CA C:PRO322 4.9 24.2 1.0
C C:TRP332 4.9 24.2 1.0
CB C:PRO322 4.9 23.6 1.0

Fluorine binding site 7 out of 8 in 3v9b

Go back to Fluorine Binding Sites List in 3v9b
Fluorine binding site 7 out of 8 in the Crystal Structure of the Catalytic Domain of PDE4D2 with (S)-N-(3-{1- [1-(3-Cyclopropylmethoxy-4-Difluoromethoxyphenyl)-2-(1-Oxypyridin-4- Yl)-Ethyl]-1H-Pyrazl-3-Yl}Phenyl)Acetamide


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 7 of Crystal Structure of the Catalytic Domain of PDE4D2 with (S)-N-(3-{1- [1-(3-Cyclopropylmethoxy-4-Difluoromethoxyphenyl)-2-(1-Oxypyridin-4- Yl)-Ethyl]-1H-Pyrazl-3-Yl}Phenyl)Acetamide within 5.0Å range:
probe atom residue distance (Å) B Occ
D:F1

b:23.0
occ:1.00
 F09 D:IHM1 0.0 23.0 1.0
C08 D:IHM1 1.4 20.8 1.0
F10 D:IHM1 2.2 20.9 1.0
O07 D:IHM1 2.3 22.1 1.0
C01 D:IHM1 3.0 20.6 1.0
C D:TRP332 3.0 18.8 1.0
N D:THR333 3.1 19.9 1.0
C02 D:IHM1 3.2 19.5 1.0
O D:TRP332 3.2 18.7 1.0
CA D:THR333 3.3 19.8 1.0
CB D:TRP332 3.4 17.5 1.0
CG2 D:ILE336 3.6 19.5 1.0
OD1 D:ASN321 3.7 17.5 1.0
OG1 D:THR333 3.8 19.2 1.0
CA D:TRP332 3.8 19.0 1.0
CB D:ILE336 4.1 21.5 1.0
CB D:THR333 4.2 20.6 1.0
CB D:ASN321 4.2 14.4 1.0
CE1 D:TYR159 4.3 16.4 1.0
CG D:ASN321 4.3 17.5 1.0
C06 D:IHM1 4.4 22.0 1.0
C D:THR333 4.5 21.1 1.0
O D:TYR329 4.5 18.2 1.0
C03 D:IHM1 4.5 18.4 1.0
CE1 D:TYR329 4.6 19.5 1.0
CG D:TRP332 4.7 17.4 1.0
OE1 D:GLN369 4.7 21.0 1.0
CD1 D:TYR329 4.8 17.3 1.0
NE2 D:GLN369 4.8 19.3 1.0
O11 D:IHM1 4.8 23.6 1.0
CD1 D:TYR159 4.8 17.5 1.0
O D:THR333 4.9 22.2 1.0
N D:TRP332 4.9 18.2 1.0
CG2 D:THR333 5.0 17.8 1.0

Fluorine binding site 8 out of 8 in 3v9b

Go back to Fluorine Binding Sites List in 3v9b
Fluorine binding site 8 out of 8 in the Crystal Structure of the Catalytic Domain of PDE4D2 with (S)-N-(3-{1- [1-(3-Cyclopropylmethoxy-4-Difluoromethoxyphenyl)-2-(1-Oxypyridin-4- Yl)-Ethyl]-1H-Pyrazl-3-Yl}Phenyl)Acetamide


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 8 of Crystal Structure of the Catalytic Domain of PDE4D2 with (S)-N-(3-{1- [1-(3-Cyclopropylmethoxy-4-Difluoromethoxyphenyl)-2-(1-Oxypyridin-4- Yl)-Ethyl]-1H-Pyrazl-3-Yl}Phenyl)Acetamide within 5.0Å range:
probe atom residue distance (Å) B Occ
D:F1

b:20.9
occ:1.00
 F10 D:IHM1 0.0 20.9 1.0
C08 D:IHM1 1.4 20.8 1.0
F09 D:IHM1 2.2 23.0 1.0
O07 D:IHM1 2.2 22.1 1.0
C01 D:IHM1 2.9 20.6 1.0
C02 D:IHM1 3.1 19.5 1.0
CB D:ASN321 3.2 14.4 1.0
CE1 D:TYR329 3.2 19.5 1.0
CG D:PRO322 3.5 18.3 1.0
CD D:PRO322 3.6 16.3 1.0
OE1 D:GLN369 3.7 21.0 1.0
CD1 D:TYR329 3.7 17.3 1.0
OD1 D:ASN321 3.8 17.5 1.0
CG D:ASN321 4.0 17.5 1.0
N D:PRO322 4.1 16.6 1.0
OG1 D:THR333 4.2 19.2 1.0
C06 D:IHM1 4.2 22.0 1.0
CE2 D:PHE372 4.3 21.8 1.0
O D:HOH456 4.4 21.0 1.0
CZ D:TYR329 4.4 17.6 1.0
CA D:ASN321 4.4 15.1 1.0
C D:ASN321 4.4 15.4 1.0
C03 D:IHM1 4.5 18.4 1.0
CB D:TRP332 4.5 17.5 1.0
CD D:GLN369 4.5 20.5 1.0
O11 D:IHM1 4.7 23.6 1.0
NE2 D:GLN369 4.7 19.3 1.0
N D:THR333 4.7 19.9 1.0
CD2 D:PHE372 4.7 19.8 1.0
OH D:TYR329 4.7 16.3 1.0
CB D:PRO322 4.8 17.8 1.0
CA D:PRO322 4.8 17.5 1.0
O D:TYR329 4.9 18.2 1.0
CA D:THR333 4.9 19.8 1.0
C D:TRP332 5.0 18.8 1.0

Reference:

C.M.Park, D.J.Jeon. Stereoselective Synthesis of Novel Pyrazole Derivatives Using Tert-Butansulfonamide As A Chiral Auxiliary Org.Biomol.Chem. V. 10 2613 2012.
ISSN: ISSN 1477-0520
PubMed: 22371117
DOI: 10.1039/C2OB06495B
Page generated: Mon Jul 14 19:50:49 2025

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