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Atomistry » Fluorine » PDB 3wyl-460d » 3zc6 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 3wyl-460d » 3zc6 » |
Fluorine in PDB 3zc6: Crystal Structure of JAK3 Kinase Domain in Complex with An Indazole Substituted Pyrrolopyrazine InhibitorEnzymatic activity of Crystal Structure of JAK3 Kinase Domain in Complex with An Indazole Substituted Pyrrolopyrazine Inhibitor
All present enzymatic activity of Crystal Structure of JAK3 Kinase Domain in Complex with An Indazole Substituted Pyrrolopyrazine Inhibitor:
2.7.1.112; 2.7.10.2; Protein crystallography data
The structure of Crystal Structure of JAK3 Kinase Domain in Complex with An Indazole Substituted Pyrrolopyrazine Inhibitor, PDB code: 3zc6
was solved by
A.Kuglstatter,
A.Jestel,
S.Nagel,
J.Boettcher,
M.Blaesse,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 3zc6:
The structure of Crystal Structure of JAK3 Kinase Domain in Complex with An Indazole Substituted Pyrrolopyrazine Inhibitor also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of JAK3 Kinase Domain in Complex with An Indazole Substituted Pyrrolopyrazine Inhibitor
(pdb code 3zc6). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Crystal Structure of JAK3 Kinase Domain in Complex with An Indazole Substituted Pyrrolopyrazine Inhibitor, PDB code: 3zc6: Jump to Fluorine binding site number: 1; 2; 3; 4; Fluorine binding site 1 out of 4 in 3zc6Go back to![]() ![]()
Fluorine binding site 1 out
of 4 in the Crystal Structure of JAK3 Kinase Domain in Complex with An Indazole Substituted Pyrrolopyrazine Inhibitor
![]() Mono view ![]() Stereo pair view
Fluorine binding site 2 out of 4 in 3zc6Go back to![]() ![]()
Fluorine binding site 2 out
of 4 in the Crystal Structure of JAK3 Kinase Domain in Complex with An Indazole Substituted Pyrrolopyrazine Inhibitor
![]() Mono view ![]() Stereo pair view
Fluorine binding site 3 out of 4 in 3zc6Go back to![]() ![]()
Fluorine binding site 3 out
of 4 in the Crystal Structure of JAK3 Kinase Domain in Complex with An Indazole Substituted Pyrrolopyrazine Inhibitor
![]() Mono view ![]() Stereo pair view
Fluorine binding site 4 out of 4 in 3zc6Go back to![]() ![]()
Fluorine binding site 4 out
of 4 in the Crystal Structure of JAK3 Kinase Domain in Complex with An Indazole Substituted Pyrrolopyrazine Inhibitor
![]() Mono view ![]() Stereo pair view
Reference:
S.M.Lynch,
J.Devicente,
J.C.Hermann,
S.Jaime-Figueroa,
S.Jin,
A.Kuglstatter,
H.Li,
A.Lovey,
J.Menke,
L.Niu,
V.Patel,
D.Roy,
M.Soth,
S.Steiner,
P.Tivitmahaisoon,
M.D.Vu,
C.Yee.
Strategic Use of Conformational Bias and Structure Based Design to Identify Potent JAK3 Inhibitors with Improved Selectivity Against the Jak Family and the Kinome. Bioorg.Med.Chem.Lett. V. 23 2793 2013.
Page generated: Wed Jul 31 23:41:27 2024
ISSN: ISSN 0960-894X PubMed: 23540648 DOI: 10.1016/J.BMCL.2013.02.012 |
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