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Atomistry » Fluorine » PDB 4csj-4dbq » 4cyq | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 4csj-4dbq » 4cyq » |
Fluorine in PDB 4cyq: Leishmania Major N-Myristoyltransferase in Complex with A Hybrid Inhibitor (Compound 45).Enzymatic activity of Leishmania Major N-Myristoyltransferase in Complex with A Hybrid Inhibitor (Compound 45).
All present enzymatic activity of Leishmania Major N-Myristoyltransferase in Complex with A Hybrid Inhibitor (Compound 45).:
2.3.1.97; Protein crystallography data
The structure of Leishmania Major N-Myristoyltransferase in Complex with A Hybrid Inhibitor (Compound 45)., PDB code: 4cyq
was solved by
J.A.Hutton,
V.Goncalves,
J.A.Brannigan,
D.Paape,
T.Waugh,
S.M.Roberts,
A.S.Bell,
A.J.Wilkinson,
D.F.Smith,
R.J.Leatherbarrow,
E.W.Tate,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4cyq:
The structure of Leishmania Major N-Myristoyltransferase in Complex with A Hybrid Inhibitor (Compound 45). also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Leishmania Major N-Myristoyltransferase in Complex with A Hybrid Inhibitor (Compound 45).
(pdb code 4cyq). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Leishmania Major N-Myristoyltransferase in Complex with A Hybrid Inhibitor (Compound 45)., PDB code: 4cyq: Fluorine binding site 1 out of 1 in 4cyqGo back to![]() ![]()
Fluorine binding site 1 out
of 1 in the Leishmania Major N-Myristoyltransferase in Complex with A Hybrid Inhibitor (Compound 45).
![]() Mono view ![]() Stereo pair view
Reference:
J.A.Hutton,
V.Goncalves,
J.A.Brannigan,
D.Paape,
M.H.Wright,
T.M.Waugh,
S.M.Roberts,
A.S.Bell,
A.J.Wilkinson,
D.F.Smith,
R.J.Leatherbarrow,
E.W.Tate.
Structure-Based Design of Potent and Selective Leishmania N- Myristoyltransferase Inhibitors. J.Med.Chem. V. 57 8664 2014.
Page generated: Thu Aug 1 00:49:30 2024
ISSN: ISSN 0022-2623 PubMed: 25238611 DOI: 10.1021/JM5011397 |
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