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Fluorine in PDB 4i8n: Crystal Structure of Protein Tyrosine Phosphatase 1B in Complex with An Inhibitor [(4-{(2S)-2-(1,3-Benzoxazol-2-Yl)-2-[(4-Fluorophenyl) Sulfamoyl]Ethyl}Phenyl)Amino](Oxo)Acetic Acid
Enzymatic activity of Crystal Structure of Protein Tyrosine Phosphatase 1B in Complex with An Inhibitor [(4-{(2S)-2-(1,3-Benzoxazol-2-Yl)-2-[(4-Fluorophenyl) Sulfamoyl]Ethyl}Phenyl)Amino](Oxo)Acetic Acid
All present enzymatic activity of Crystal Structure of Protein Tyrosine Phosphatase 1B in Complex with An Inhibitor [(4-{(2S)-2-(1,3-Benzoxazol-2-Yl)-2-[(4-Fluorophenyl) Sulfamoyl]Ethyl}Phenyl)Amino](Oxo)Acetic Acid:
3.1.3.48;
3.1.3.48;
Protein crystallography data
The structure of Crystal Structure of Protein Tyrosine Phosphatase 1B in Complex with An Inhibitor [(4-{(2S)-2-(1,3-Benzoxazol-2-Yl)-2-[(4-Fluorophenyl) Sulfamoyl]Ethyl}Phenyl)Amino](Oxo)Acetic Acid, PDB code: 4i8n
was solved by
S.M.V.V.V.Reddy,
K.N.Rao,
H.Subramanya,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 27.74 / 2.50 |
| Space group | P 31 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 87.890, 87.890, 103.680, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 18.4 / 24.8 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Protein Tyrosine Phosphatase 1B in Complex with An Inhibitor [(4-{(2S)-2-(1,3-Benzoxazol-2-Yl)-2-[(4-Fluorophenyl) Sulfamoyl]Ethyl}Phenyl)Amino](Oxo)Acetic Acid
(pdb code 4i8n). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of Protein Tyrosine Phosphatase 1B in Complex with An Inhibitor [(4-{(2S)-2-(1,3-Benzoxazol-2-Yl)-2-[(4-Fluorophenyl) Sulfamoyl]Ethyl}Phenyl)Amino](Oxo)Acetic Acid, PDB code: 4i8n:
In total only one binding site of Fluorine was determined in the Crystal Structure of Protein Tyrosine Phosphatase 1B in Complex with An Inhibitor [(4-{(2S)-2-(1,3-Benzoxazol-2-Yl)-2-[(4-Fluorophenyl) Sulfamoyl]Ethyl}Phenyl)Amino](Oxo)Acetic Acid, PDB code: 4i8n:
Fluorine binding site 1 out of 1 in 4i8n
Go back to
Fluorine Binding Sites List in 4i8n
Fluorine binding site 1 out
of 1 in the Crystal Structure of Protein Tyrosine Phosphatase 1B in Complex with An Inhibitor [(4-{(2S)-2-(1,3-Benzoxazol-2-Yl)-2-[(4-Fluorophenyl) Sulfamoyl]Ethyl}Phenyl)Amino](Oxo)Acetic Acid
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of Protein Tyrosine Phosphatase 1B in Complex with An Inhibitor [(4-{(2S)-2-(1,3-Benzoxazol-2-Yl)-2-[(4-Fluorophenyl) Sulfamoyl]Ethyl}Phenyl)Amino](Oxo)Acetic Acid within 5.0Å range:
|
Reference:
M.V.Reddy,
C.Ghadiyaram,
S.K.Panigrahi,
N.R.Krishnamurthy,
S.Hosahalli,
A.P.Chandrasekharappa,
D.Manna,
S.E.Badiger,
P.K.Dubey,
L.N.Mangamoori.
X-Ray Structure of PTP1B in Complex with A New PTP1B Inhibitor. Protein Pept.Lett. V. 21 90 2014.
ISSN: ISSN 0929-8665
PubMed: 23964742
Page generated: Mon Jul 14 22:10:34 2025
ISSN: ISSN 0929-8665
PubMed: 23964742
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