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Atomistry » Fluorine » PDB 4iju-4j0t » 4iqv » |
Fluorine in PDB 4iqv: Tdt Core in Complex with Inhibitor 6-[4-(3-Fluorobenzoyl)-1H-Pyrrol-2- Yl]-2-Hydroxy-4-Oxohexa-2,5-Dienoic Acid and SsdnaEnzymatic activity of Tdt Core in Complex with Inhibitor 6-[4-(3-Fluorobenzoyl)-1H-Pyrrol-2- Yl]-2-Hydroxy-4-Oxohexa-2,5-Dienoic Acid and Ssdna
All present enzymatic activity of Tdt Core in Complex with Inhibitor 6-[4-(3-Fluorobenzoyl)-1H-Pyrrol-2- Yl]-2-Hydroxy-4-Oxohexa-2,5-Dienoic Acid and Ssdna:
2.7.7.31; Protein crystallography data
The structure of Tdt Core in Complex with Inhibitor 6-[4-(3-Fluorobenzoyl)-1H-Pyrrol-2- Yl]-2-Hydroxy-4-Oxohexa-2,5-Dienoic Acid and Ssdna, PDB code: 4iqv
was solved by
J.Gouge,
M.Delarue,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4iqv:
The structure of Tdt Core in Complex with Inhibitor 6-[4-(3-Fluorobenzoyl)-1H-Pyrrol-2- Yl]-2-Hydroxy-4-Oxohexa-2,5-Dienoic Acid and Ssdna also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Tdt Core in Complex with Inhibitor 6-[4-(3-Fluorobenzoyl)-1H-Pyrrol-2- Yl]-2-Hydroxy-4-Oxohexa-2,5-Dienoic Acid and Ssdna
(pdb code 4iqv). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Tdt Core in Complex with Inhibitor 6-[4-(3-Fluorobenzoyl)-1H-Pyrrol-2- Yl]-2-Hydroxy-4-Oxohexa-2,5-Dienoic Acid and Ssdna, PDB code: 4iqv: Fluorine binding site 1 out of 1 in 4iqvGo back to![]() ![]()
Fluorine binding site 1 out
of 1 in the Tdt Core in Complex with Inhibitor 6-[4-(3-Fluorobenzoyl)-1H-Pyrrol-2- Yl]-2-Hydroxy-4-Oxohexa-2,5-Dienoic Acid and Ssdna
![]() Mono view ![]() Stereo pair view
Reference:
R.Costi,
G.Cuzzucoli Crucitti,
L.Pescatori,
A.Messore,
L.Scipione,
S.Tortorella,
A.Amoroso,
E.Crespan,
P.Campiglia,
B.Maresca,
A.Porta,
I.Granata,
E.Novellino,
J.Gouge,
M.Delarue,
G.Maga,
R.Di Santo.
New Nucleotide-Competitive Non-Nucleoside Inhibitors of Terminal Deoxynucleotidyl Transferase: Discovery, Characterization, and Crystal Structure in Complex with the Target. J.Med.Chem. V. 56 7431 2013.
Page generated: Mon Jul 14 22:21:14 2025
ISSN: ISSN 0022-2623 PubMed: 23968551 DOI: 10.1021/JM4010187 |
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